Literature summary for 3.5.2.2 extracted from

Jacob, E.; Henco, K.; Marcinowski, S.; Schenk, G.
Verfahren zur Herstellung von mesophilen Mikroorganismen, die eine bei h�herer Temperatur aktive D-Hydantoinase enthalten (1987), (BASF A. -6) Ger. Offen. DE3535987 A1, (Cl. C12N15/00), , 1-18.

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Application

Application	Comment	Organism
medicine	D-amino acids for preparation of beta-lactam antibiotics like semisynthetic penicillins and cephalosporins such as ampicillin, amoxicillin and cefadroxyl, peptide hormones and pesticides	Thermus sp.

Cloned(Commentary)

Cloned (Comment)	Organism
D-hydantoinase genes cloned and sequenced, Escherichia coli transformed with cosmid vectors, D-hydantoinase expressed and identified	Thermus sp.
expressed in Escherichia coli BL21	Thermus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
hydantoin + H2O	Thermus sp.	-	N-carbamoyl glycine	-	?

Organism

Organism	UniProt	Comment	Textmining
Thermus sp.	-	thermophilic bacterial strains, CBS 303.80 and CBS363.80, asporogenic gram-negative	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,6-dihydrouracil + H2O	-	Thermus sp.	3-ureidopropionate	-	?
hydantoin + H2O	-	Thermus sp.	N-carbamoyl glycine	-	?

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Release 2023.1 (January 2023)