3.5.2.2: dihydropyrimidinase
This is an abbreviated version!
For detailed information about dihydropyrimidinase, go to the full flat file.
Word Map on EC 3.5.2.2
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3.5.2.2
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5-fluorouracil
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thymidylate
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dihydropyridine
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colorectal
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fluoropyrimidine
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phosphorylase
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thymidine
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capecitabine
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l-type
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uracil
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nifedipine
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orotate
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resect
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blocker
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pharmacogenetic
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1,4-dihydropyridine
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tegafur
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prodrugs
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voltage-dependent
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dihydrouracil
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5-fu-based
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fluoropyrimidine-based
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nitrendipine
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leucovorin
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phosphoribosyltransferase
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diltiazem
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oxaliplatin
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irinotecan
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hemoperfusion
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phosphoribosyl
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5-fluorouracil-based
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mucositis
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neutropenia
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pyrrolizidine
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11-ketotestosterone
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excitation-contraction
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isradipine
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nisoldipine
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coniferyl
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5-fu-induced
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dihydropyridine-sensitive
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felodipine
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5\'-dfur
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dihydroorotase
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photochromic
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nicardipine
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synthesis
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industry
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5'-deoxy-5-fluorouridine
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pretherapeutic
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omega-conotoxin
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nutrition
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medicine
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hand-foot
- 3.5.2.2
- 5-fluorouracil
- thymidylate
-
dihydropyridine
- colorectal
-
fluoropyrimidine
- phosphorylase
- thymidine
- capecitabine
-
l-type
- uracil
- nifedipine
- orotate
-
resect
-
blocker
-
pharmacogenetic
-
1,4-dihydropyridine
-
tegafur
-
prodrugs
-
voltage-dependent
- dihydrouracil
-
5-fu-based
-
fluoropyrimidine-based
-
nitrendipine
- leucovorin
-
phosphoribosyltransferase
- diltiazem
- oxaliplatin
- irinotecan
-
hemoperfusion
-
phosphoribosyl
-
5-fluorouracil-based
- mucositis
- neutropenia
-
pyrrolizidine
- 11-ketotestosterone
-
excitation-contraction
- isradipine
- nisoldipine
-
coniferyl
-
5-fu-induced
-
dihydropyridine-sensitive
- felodipine
-
5\'-dfur
- dihydroorotase
-
photochromic
- nicardipine
- synthesis
- industry
- 5'-deoxy-5-fluorouridine
-
pretherapeutic
-
omega-conotoxin
- nutrition
- medicine
-
hand-foot
Reaction
Synonyms
4,5-dihydropyrimidine amidohydrolase, aaHYD, bar9HYD, bpHYD, bsHYD, CRMP, D-CpHPG, D-HYD, D-hydantionase, D-hydantoin-hydrolyzing enzyme, D-hydantoinase, D-PfHYD, DHP, DHP-1, DHP-2, DHPase, dht, DHTase, dihydropyrimidase/hydantoinase, Dihydropyrimidinase, dihydropyrimidine amidohydrolase, dihydropyrimidine dehydrogenase, HDT, HYD, hydantoin peptidase, hydantoinase, hydropyrimidine hydrase, hyuH, L-Hyd, L-hydantoinase, microbial hydantoinase, P479, PA0441, PaDHPase, PYD2, PydB, pyrimidine hydrase, SmelDhp, thHYD
ECTree
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Specific Activity
Specific Activity on EC 3.5.2.2 - dihydropyrimidinase
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0.014
0.015
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strain 50090, incubated with hydantoin, isopropylhydantoin as substrate
0.016
0.033
0.051
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strain 291, incubated with hydantoin, isopropylhydantoin as substrate
0.085
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DL-5-p-hydroxyphenylhydantoin conversion induced by DL-5-(1-methylpropyl)hydantoin
0.091
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DL-5-p-hydroxyphenylhydantoin conversion induced by DL-hydantoin-5-acetic acid
0.127
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strain 549, incubated with hydantoin, isopropylhydantoin as substrate
0.17
EDTA-dialyzed/Co2+-substituted enzyme incubated with hydantoin as substrate
0.185
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strain 84, incubated with hydantoin, isopropylhydantoin as substrate
0.216
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DL-5-p-hydroxyphenylhydantoin conversion induced by DL-5-methylhydantoin
0.225
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DL-5-p-hydroxyphenylhydantoin conversion induced by DL-5-hydroxymethylhydantoin
0.3
0.36
EDTA-dialyzed enzyme incubated with Fe2+ with DL-p-hydroxyphenylhydantoin as substrate
0.385
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DL-5-p-hydroxyphenylhydantoin conversion induced by DL-5-p-hydroxyphenylhydantoin
0.46
EDTA-dialyzed enzyme incubated with Ca2+ with DL-p-hydroxyphenylhydantoin as substrate
0.49
EDTA-dialyzed enzyme incubated with Ni2+ with DL-p-hydroxyphenylhydantoin as substrate
0.52
EDTA-dialyzed enzyme with D,L-p-hydroxyphenylhydantoin as substrate
0.54
EDTA-dialyzed enzyme incubated with Mg2+ with DL-p-hydroxyphenylhydantoin as substrate
0.62
0.635
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DL-5-p-hydroxyphenylhydantoin conversion induced by DL-5-phenylhydantoin
0.68
EDTA-dialyzed enzyme incubated with Cu2+ with DL-p-hydroxyphenylhydantoin as substrate
0.73
0.74
substrate 5,6-dihydrouracil, pH 8.0, 25°C, purified recombinant enzyme in presence of 1 mM Cd2+
0.81
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strain 50154, incubated with hydantoin, dihydrouracil as substrate
0.82
0.826
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DL-5-p-hydroxyphenylhydantoin conversion induced by DL-5-phenylpropylhydantoin
0.89
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DL-5-p-hydroxyphenylhydantoin conversion induced by DL-5-methylthiethylhydantoin
0.91
substrate 5,6-dihydrouracil, pH 8.0, 25°C, purified recombinant enzyme in presence of 1 mM Ni2+
0.98
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strain 50108, incubated with hydantoin, dihydrouracil as substrate
1.11
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strain 50106, incubated with hydantoin, dihydrouracil as substrate
1.128
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DL-5-p-hydroxyphenylhydantoin conversion induced by DL-5-isobutylhydantoin
1.286
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DL-5-p-hydroxyphenylhydantoin conversion induced by DL-5-benylhydantoin
1.4
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strain 50090, incubated with hydantoin, dihydrouracil as substrate
1.591
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DL-5-p-hydroxyphenylhydantoin conversion induced by DL-5-(2-indolymethyl)hydantoin
1.69
EDTA-dialyzed/Co2+-substituted enzyme incubated with DL-p-hydroxyphenylhydantoin as substrate
1.72
substrate 5,6-dihydrouracil, pH 8.0, 25°C, purified recombinant enzyme in presence of 1 mM Mn2+
10.65
after 3.4fold purification, using DL-5-phenylhydantoin as a substrate, in 50 mM Tris-HCl buffer, pH 8.0
10.75
11.84
after 3.4fold purification, using DL-p-hydroxyphenylhydantoin as a substrate, in 50 mM Tris-HCl buffer, pH 8.0
14.3
crude extract, using DL-hydantoin as a substrate, in 50 mM Tris-HCl buffer, pH 8.0
2.38
EDTA-dialyzed enzyme incubated with Mn2+ with DL-p-hydroxyphenylhydantoin as substrate
2.9
substrate 5,6-dihydrouracil, pH 8.0, 25°C, purified recombinant enzyme in presence of 1 mM Zn2+
3.56
EDTA-dialyzed/Co2+-substituted enzyme incubated with dihydrouracil as substrate
3.6
EDTA-dialyzed enzyme incubated with Co2+ with DL-p-hydroxyphenylhydantoin as substrate
48.5
after 3.4fold purification, using DL-hydantoin as a substrate, in 50 mM Tris-HCl buffer, pH 8.0
5.8 - 5.9
substrate 5,6-dihydrouracil, pH 8.0, 25°C, purified recombinant enzyme in presence of 1 mM Co2+
5.93
purified recombinant enzyme from Escherichia coli JM109pJAVI2
600.8
after 3.4fold purification, using 5,6-dihydrouracil as a substrate, in 50 mM Tris-HCl buffer, pH 8.0
8.41
additional information
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strain 50106, incubated with hydantoin, isopropylhydantoin as substrate
EDTA-dialyzed/Co2+-substituted enzyme incubated with DL-5(2-(methylthio)-ethyl)hydantoin as substrate
0.62
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strain 2005, incubated with hydantoin, dihydrouracil as substrate
EDTA-dialyzed enzyme incubated with Zn2+ with DL-p-hydroxyphenylhydantoin as substrate
substrate 5,6-dihydrouracil, pH 8.0, 25°C, purified recombinant enzyme in absence of metal ion
0.82
substrate 5,6-dihydrouracil, pH 8.0, 25°C, purified recombinant enzyme in presence of 1 mM Ca2+
0.82
substrate 5,6-dihydrouracil, pH 8.0, 25°C, purified recombinant enzyme in presence of 1 mM Mg2+
hydantoinase in recombinant Escherichia coli cells has a specific activity of 0.326 mU/mgcdw with 6-(4-nitrophenyl)dihydropyrimidine-2,4(1H,3H)-dione
additional information
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only the last four residues can be deleted without significantly affecting the enzyme activity