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3.5.2.2: dihydropyrimidinase

This is an abbreviated version!
For detailed information about dihydropyrimidinase, go to the full flat file.

Word Map on EC 3.5.2.2

Reaction

5,6-dihydrouracil
+
H2O
=
3-ureidopropanoate

Synonyms

4,5-dihydropyrimidine amidohydrolase, aaHYD, bar9HYD, bpHYD, bsHYD, CRMP, D-CpHPG, D-HYD, D-hydantionase, D-hydantoin-hydrolyzing enzyme, D-hydantoinase, D-PfHYD, DHP, DHP-1, DHP-2, DHPase, dht, DHTase, dihydropyrimidase/hydantoinase, Dihydropyrimidinase, dihydropyrimidine amidohydrolase, dihydropyrimidine dehydrogenase, HDT, HYD, hydantoin peptidase, hydantoinase, hydropyrimidine hydrase, hyuH, L-Hyd, L-hydantoinase, microbial hydantoinase, P479, PA0441, PaDHPase, PYD2, PydB, pyrimidine hydrase, SmelDhp, thHYD

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.2 dihydropyrimidinase

pH Stability

pH Stability on EC 3.5.2.2 - dihydropyrimidinase

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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 7
-
strain 2.2, other strains more stable around pH 5
209289
5.5 - 8.5
6 - 12
the enzymatic activity is completely lost under pH 6.0, it maintains nearly 60% activity at a pH above 12
690200
6 - 7
-
most stable in this range, more stable at alkaline than at acidic pH
209283
6 - 9
-
in the absence of Zn2+, the protein acquires a tetrameric functional structure at pH 6.0, which is stable up to pH 9
696766
6 - 9.5
7 - 10
-
685741
7.1 - 7.2
-
more stable in slightly alkaline buffers
209274
8.5 - 9.5
-
most stable in this range
209297
9
-
immobilized enzyme is completely stable
667176
additional information