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3.5.2.2: dihydropyrimidinase

This is an abbreviated version!
For detailed information about dihydropyrimidinase, go to the full flat file.

Word Map on EC 3.5.2.2

Reaction

5,6-dihydrouracil
+
H2O
=
3-ureidopropanoate

Synonyms

4,5-dihydropyrimidine amidohydrolase, aaHYD, bar9HYD, bpHYD, bsHYD, CRMP, D-CpHPG, D-HYD, D-hydantionase, D-hydantoin-hydrolyzing enzyme, D-hydantoinase, D-PfHYD, DHP, DHP-1, DHP-2, DHPase, dht, DHTase, dihydropyrimidase/hydantoinase, Dihydropyrimidinase, dihydropyrimidine amidohydrolase, dihydropyrimidine dehydrogenase, HDT, HYD, hydantoin peptidase, hydantoinase, hydropyrimidine hydrase, hyuH, L-Hyd, L-hydantoinase, microbial hydantoinase, P479, PA0441, PaDHPase, PYD2, PydB, pyrimidine hydrase, SmelDhp, thHYD

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.2 dihydropyrimidinase

Expression

Expression on EC 3.5.2.2 - dihydropyrimidinase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
hydantoinase and N-carbamoylase activities are regulated by the growth phase of the cell, the presence or absence of hydantoin, and these regulatory pathways act at both the transcriptional and post-transcriptional levels. hyuH transcription is not sensitive to nitrogen catabolite repression in strain RU-AE01
-
hydantoinase and N-carbamoylase activity are induced approximately 3fold in cells grown in medium with hydantoin as compared with 0.02% casamino acids as a nitrogen source. A 2fold increase in hydantoinase gene hyuH transcriptional activity is observed in medium containing hydantoin as compared with cells grown in minimal medium
-
significant reduction in both hydantoinase and N-carbamoylase activities in cells grown in medium containing the repressive nitrogen source 0.5% casamino acids as compared with the non-repressive nitrogen source 0.02% casamino acids
-