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3.5.2.2: dihydropyrimidinase

This is an abbreviated version!
For detailed information about dihydropyrimidinase, go to the full flat file.

Word Map on EC 3.5.2.2

Reaction

5,6-dihydrouracil
+
H2O
=
3-ureidopropanoate

Synonyms

4,5-dihydropyrimidine amidohydrolase, aaHYD, bar9HYD, bpHYD, bsHYD, CRMP, D-CpHPG, D-HYD, D-hydantionase, D-hydantoin-hydrolyzing enzyme, D-hydantoinase, D-PfHYD, DHP, DHP-1, DHP-2, DHPase, dht, DHTase, dihydropyrimidase/hydantoinase, Dihydropyrimidinase, dihydropyrimidine amidohydrolase, dihydropyrimidine dehydrogenase, HDT, HYD, hydantoin peptidase, hydantoinase, hydropyrimidine hydrase, hyuH, L-Hyd, L-hydantoinase, microbial hydantoinase, P479, PA0441, PaDHPase, PYD2, PydB, pyrimidine hydrase, SmelDhp, thHYD

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.2 dihydropyrimidinase

KCat KM Value

KCat KM Value on EC 3.5.2.2 - dihydropyrimidinase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.043
2-chlorobenzenehydantoin
pH 9.0, 45°C, recombinant enzyme
9.87
4-hydroxyphenylhydantoin
pH 9.0, 45°C, recombinant enzyme
0.4
D-5-benzylhydantoin
-
pH 8.0, 40°C
0.214
D-5-butylhydantoin
-
pH 8.0, 40°C
0.944
D-5-ethylhydantoin
-
pH 8.0, 40°C
0.2
D-5-isobutylhydantoin
-
pH 8.0, 40°C
0.114
D-5-isopropylhydantoin
-
pH 8.0, 40°C
0.273
D-5-methyl-thio-ethylhydantoin
-
pH 8.0, 40°C
2.736
D-5-methylhydantoin
-
pH 8.0, 40°C
0.231
D-5-propylhydantoin
-
pH 8.0, 40°C
0.667
dihydrouracil
-
pH 8.0, 40°C
0.05
DL-5-(p-hydroxyphenyl)hydantoin
-
pH 8.0, 40°C
1
DL-5-methyldihydrouracil
-
pH 8.0, 40°C
0.012
DL-6-isopropyldihydrouracil
-
pH 8.0, 40°C
0.072
DL-6-methyldihydrouracil
-
pH 8.0, 40°C
0.25 - 20.95
DL-p-hydroxyphenylhydantoin
0.022 - 0.763
hydantoin
0.31
indolmethylhydantoin
pH 9.0, 45°C, recombinant enzyme
88.46
isobutylhydantoin
pH 9.0, 45°C, recombinant enzyme
10.13
isopropylhydantoin
pH 9.0, 45°C, recombinant enzyme
0.31
phenylmethylhydantoin
pH 9.0, 45°C, recombinant enzyme