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3.5.2.2: dihydropyrimidinase

This is an abbreviated version!
For detailed information about dihydropyrimidinase, go to the full flat file.

Word Map on EC 3.5.2.2

Reaction

5,6-dihydrouracil
+
H2O
=
3-ureidopropanoate

Synonyms

4,5-dihydropyrimidine amidohydrolase, aaHYD, bar9HYD, bpHYD, bsHYD, CRMP, D-CpHPG, D-HYD, D-hydantionase, D-hydantoin-hydrolyzing enzyme, D-hydantoinase, D-PfHYD, DHP, DHP-1, DHP-2, DHPase, dht, DHTase, dihydropyrimidase/hydantoinase, Dihydropyrimidinase, dihydropyrimidine amidohydrolase, dihydropyrimidine dehydrogenase, HDT, HYD, hydantoin peptidase, hydantoinase, hydropyrimidine hydrase, hyuH, L-Hyd, L-hydantoinase, microbial hydantoinase, P479, PA0441, PaDHPase, PYD2, PydB, pyrimidine hydrase, SmelDhp, thHYD

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.2 dihydropyrimidinase

KM Value

KM Value on EC 3.5.2.2 - dihydropyrimidinase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
8.57
2-chlorobenzenehydantoin
pH 9.0, 45°C, recombinant enzyme
7.52
4-hydroxyphenylhydantoin
pH 9.0, 45°C, recombinant enzyme
0.017 - 0.026
5,6-Dihydrothymine
0.008 - 117
5,6-dihydrouracil
0.017 - 0.025
5-bromo-5,6-dihydrouracil
0.02
5-bromodihydrouracil
-
-
0.018
5-iododihydrouracil
-
-
34
5-isopropylhydantoin
-
-
62.5
5-methylhydantoin
-
-
5.8
allantoin
-
-
0.028 - 0.069
beta-Ureidoisobutyrate
0.015 - 0.079
beta-ureidopropionate
14.98 - 27.03
D,L-benzylhydantoin
5
D-5-benzylhydantoin
-
pH 8.0, 40°C
14
D-5-butylhydantoin
-
pH 8.0, 40°C
3.4 - 18
D-5-ethylhydantoin
10
D-5-isobutylhydantoin
-
pH 8.0, 40°C
44
D-5-isopropylhydantoin
-
pH 8.0, 40°C
66
D-5-methyl-thio-ethylhydantoin
-
pH 8.0, 40°C
72
D-5-methylhydantoin
-
pH 8.0, 40°C
0.4 - 7
D-5-methylthioethylhydantoin
26
D-5-propylhydantoin
-
pH 8.0, 40°C
0.015
Dihydrothymine
-
-
1.1 - 3
dihydrouracil
28 - 34
DL-5-(2-methylthioethyl)-hydantoin
40.7
DL-5-(2-methylthioethyl)hydantoin
-
-
20
DL-5-(p-hydroxyphenyl)hydantoin
-
pH 8.0, 40°C
6.8
DL-5-benzylhydantoin
-
-
12.8
DL-5-butylhydantoin
-
-
4.9
DL-5-isobutylhydantoin
-
-
17.2
DL-5-isopropylhydantoin
-
-
1
DL-5-methyldihydrouracil
-
pH 8.0, 40°C
27.8
DL-5-methylhydantoin
-
-
7.9 - 50
DL-5-phenylhydantoin
58.8
DL-5-phenyllhydantoin
-
-
25.6
DL-5-propylhydantoin
-
-
81
DL-6-isopropyldihydrouracil
-
pH 8.0, 40°C
111
DL-6-methyldihydrouracil
-
pH 8.0, 40°C
0.074 - 27
DL-hydroxyphenylhydantoin
2.9 - 18
DL-p-hydroxyphenylhydantoin
1.28 - 830
hydantoin
2.1
Hydrothymine
-
-
117.5
hydrouracil
-
-
4.64
indolmethylhydantoin
pH 9.0, 45°C, recombinant enzyme
4.42
isobutylhydantoin
pH 9.0, 45°C, recombinant enzyme
7.63
isopropylhydantoin
pH 9.0, 45°C, recombinant enzyme
0.1 - 3.7
L-5-ethylhydantoin
0.4 - 4.7
L-5-methylthioethylhydantoin
1.92 - 2.26
N-Carbamoyl-beta-alanine
1.19 - 1.59
N-carbamoyl-beta-aminoisobutyric acid
30.7 - 47.2
p-hydroxyphenylhydantoin
8 - 32.1
phenylhydantoin
9.49
phenylmethylhydantoin
pH 9.0, 45°C, recombinant enzyme
additional information
additional information
Michaelis-Menten kinetics
-