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3.5.2.2: dihydropyrimidinase

This is an abbreviated version!
For detailed information about dihydropyrimidinase, go to the full flat file.

Word Map on EC 3.5.2.2

Reaction

5,6-dihydrouracil
+
H2O
=
3-ureidopropanoate

Synonyms

4,5-dihydropyrimidine amidohydrolase, aaHYD, bar9HYD, bpHYD, bsHYD, CRMP, D-CpHPG, D-HYD, D-hydantionase, D-hydantoin-hydrolyzing enzyme, D-hydantoinase, D-PfHYD, DHP, DHP-1, DHP-2, DHPase, dht, DHTase, dihydropyrimidase/hydantoinase, Dihydropyrimidinase, dihydropyrimidine amidohydrolase, dihydropyrimidine dehydrogenase, HDT, HYD, hydantoin peptidase, hydantoinase, hydropyrimidine hydrase, hyuH, L-Hyd, L-hydantoinase, microbial hydantoinase, P479, PA0441, PaDHPase, PYD2, PydB, pyrimidine hydrase, SmelDhp, thHYD

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.2 dihydropyrimidinase

Turnover Number

Turnover Number on EC 3.5.2.2 - dihydropyrimidinase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.37
2-chlorobenzenehydantoin
pH 9.0, 45°C, recombinant enzyme
74.2
4-hydroxyphenylhydantoin
pH 9.0, 45°C, recombinant enzyme
2
D-5-benzylhydantoin
-
pH 8.0, 40°C
3
D-5-butylhydantoin
-
pH 8.0, 40°C
16.6 - 37.3
D-5-ethylhydantoin
2
D-5-isobutylhydantoin
-
pH 8.0, 40°C
5
D-5-isopropylhydantoin
-
pH 8.0, 40°C
18
D-5-methyl-thio-ethylhydantoin
-
pH 8.0, 40°C
197
D-5-methylhydantoin
-
pH 8.0, 40°C
4.9 - 92.6
D-5-methylthioethylhydantoin
6
D-5-propylhydantoin
-
pH 8.0, 40°C
2 - 6.2
dihydrouracil
1
DL-5-(p-hydroxyphenyl)hydantoin
-
pH 8.0, 40°C
1
DL-5-methyldihydrouracil
-
pH 8.0, 40°C
1
DL-6-isopropyldihydrouracil
-
pH 8.0, 40°C
8
DL-6-methyldihydrouracil
-
pH 8.0, 40°C
11 - 280
DL-hydroxyphenylhydantoin
4.6 - 62
DL-p-hydroxyphenylhydantoin
3.04 - 450
hydantoin
7
Hydrothymine
-
-
71.7
hydrouracil
-
-
1.43
indolmethylhydantoin
pH 9.0, 45°C, recombinant enzyme
391
isobutylhydantoin
pH 9.0, 45°C, recombinant enzyme
77.3
isopropylhydantoin
pH 9.0, 45°C, recombinant enzyme
0.0055 - 0.44
L-5-ethylhydantoin
0.6 - 11.4
L-5-methylthioethylhydantoin
2.91
phenylmethylhydantoin
pH 9.0, 45°C, recombinant enzyme