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3.5.2.2: dihydropyrimidinase

This is an abbreviated version!
For detailed information about dihydropyrimidinase, go to the full flat file.

Word Map on EC 3.5.2.2

Reaction

5,6-dihydrouracil
+
H2O
=
3-ureidopropanoate

Synonyms

4,5-dihydropyrimidine amidohydrolase, aaHYD, bar9HYD, bpHYD, bsHYD, CRMP, D-CpHPG, D-HYD, D-hydantionase, D-hydantoin-hydrolyzing enzyme, D-hydantoinase, D-PfHYD, DHP, DHP-1, DHP-2, DHPase, dht, DHTase, dihydropyrimidase/hydantoinase, Dihydropyrimidinase, dihydropyrimidine amidohydrolase, dihydropyrimidine dehydrogenase, HDT, HYD, hydantoin peptidase, hydantoinase, hydropyrimidine hydrase, hyuH, L-Hyd, L-hydantoinase, microbial hydantoinase, P479, PA0441, PaDHPase, PYD2, PydB, pyrimidine hydrase, SmelDhp, thHYD

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.2 dihydropyrimidinase

pH Range

pH Range on EC 3.5.2.2 - dihydropyrimidinase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 10
6 - 10.5
the enzyme displays highest activity at pH 9.0 and shows over 90% of maximal activity at pH 8.5-9.5, and over 50% at pH 7.0-10.5. Below pH 7.5, the activity decreases sharply, 5% of maximal activity at pH 6.0
6 - 11
-
at 40°C
6 - 9.5
7 - 8
-
wild-type enzyme, 100% activity
7 - 9
DL-p-hydroxyphenylhydantoin as substrate
8 - 9.7
-
pH 8.0: about 55% of maximal activity, pH 9.7: about 90% of maximal activity