3.2.2.22: rRNA N-glycosylase
This is an abbreviated version!
For detailed information about rRNA N-glycosylase, go to the full flat file.
Word Map on EC 3.2.2.22
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3.2.2.22
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checkpoint
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immunotherapy
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lymphocyte
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death-ligand
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nsclc
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non-small
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t-cells
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tumor-infiltrating
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clinicopathological
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immunotoxins
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subtypes
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cd8
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pembrolizumab
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melanoma
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adenocarcinoma
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progression-free
-
death-1
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ligand-1
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resect
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lymphoma
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toxin-producing
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anti-pd-1
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dendritic
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uremic
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nivolumab
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monotherapy
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durable
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hemolytic
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first-line
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ctla-4
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urothelial
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tregs
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intratumoral
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evasion
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immune-related
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non-small-cell
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immunotherapeutic
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diarrhea
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treatment-related
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alk
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second-line
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platinum-based
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castor
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myeloid-derived
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shigella
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neoadjuvant
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foxp3
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cytotoxin
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serogroups
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agriculture
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biotechnology
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nutrition
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medicine
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pharmacology
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diagnostics
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analysis
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recist
- 3.2.2.22
-
checkpoint
-
immunotherapy
- lymphocyte
-
death-ligand
-
nsclc
-
non-small
- t-cells
-
tumor-infiltrating
-
clinicopathological
- immunotoxins
- subtypes
- cd8
-
pembrolizumab
- melanoma
- adenocarcinoma
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progression-free
-
death-1
- ligand-1
-
resect
- lymphoma
-
toxin-producing
-
anti-pd-1
- dendritic
-
uremic
-
nivolumab
-
monotherapy
-
durable
-
hemolytic
-
first-line
-
ctla-4
-
urothelial
-
tregs
-
intratumoral
-
evasion
-
immune-related
-
non-small-cell
-
immunotherapeutic
-
diarrhea
-
treatment-related
- alk
-
second-line
-
platinum-based
- castor
-
myeloid-derived
- shigella
-
neoadjuvant
- foxp3
-
cytotoxin
-
serogroups
- agriculture
- biotechnology
- nutrition
- medicine
- pharmacology
- diagnostics
- analysis
-
recist
Reaction
Synonyms
(ribosome-inactivating protein)-like protein, abelesculin, ABRaA, abrin, abrin-a A chain, Abrus precatorius agglutinin, alpha-MC, alpha-momorcharin, alpha-pisavin, antiviral protein DAP-30, aralin, B-32, balsamin, BBAP1, BE27, beta-momorcharin, beta-pisavin, Bougainvillea xbuttiana antiviral protein 1, bouganin, camphorin, CAP30, cinnamomin, Cochinin B, cytotoxic ribosome-inactivating lectin, D6D54_07625, D6D54_08385, D6D54_08880, depurinating rRNA N-glycosidase, dianthin 30, dianthin 32, dianthin-30, diphtheria toxin, ebulin b, ebulitin alpha, ebulitin beta, ebulitin gamma, gelonin, gysophilin, hispin, IRAb, IRIP, Iris agglutinin b, Iris ribosome-inactivating protein, JIP60, karasurin-A, KML, lamjapin, luffaculin I, luffin P1, lychnin, MAP, marmorin, ME1, Mirabilis antiviral protein, mistletoe lectin I, mistletoe lectin II, mistletoe lectin III, ML-I, MLI, MLII, MLIII, MOD, modeccin, momorcochin, momorcochin-S, momordin, momordin I, momordin II, momorgrosvin, More, N-glycosidase, n-TCS, neo-trichosanthin, nigrin b, nigritin f1, nigritin f2, PAG, PAGase, PAP, PAP-I, PAP-II, PAP-III, PAP-R, PAP-S, PD-L, PD-L1, PD-L4, pepocin, PGase, pokeweed anti-viral protein, pokeweed antiviral protein, polynucleotide:adenosine glycosidase, polynucleotide:adenosine glycosylase, porrectin, RA, RCA-II, ribosomal inactivating protein, ribosomal ribonucleate N-glycosidase, ribosome inactivating protein, ribosome-inactivating protein, ribosome-inactivating protein 3, ribosome-inactivating protein type II, ribosome-inactivating proteins, ribosome-inactivating type II protein, ribosome-specific N-glycosidase, ricin, ricin A, ricin A chain, ricin A-chain, ricin toxin A-chain, ricin-A-chain, ricin-like protein, Ricinus communis agglutinin, Ricinus communis agglutinin II, RIP, RIP-1, RIP1, RIP2, RIPII, riproximin, RLP1, RLP2, RLP3, RLP4, RLP5, RLP6, RNA N-glycosidase, RNA-NGA, RNA-specific N-glycosidase, RNase Bo, Rpx, rRNA N-glycosidase, RTA, Sambucus nigra agglutinin, Sambucus nigra agglutinin I, SAP, saporin, saporin 6, saporin S-6, saporin S6, saporin-6, saporin-L1, saporin-S6, saporins, SBA, SCO7092, SEPIN, Shiga toxin, Shiga toxin 1, Shiga toxin 1 subunit A, Shiga toxin 2, Shiga toxin 2 subunit A, Shiga toxin type 1, Shiga toxin type 2, Shiga toxin-1, shiga-like toxin, shiga-like toxin I, sieboldin-b, single-chain ribosome-inactivating protein, SLT-I, SLT-II, SLT-IIv, SNA, SNA-I, SNA-V, SnaI, SNAIf, SNAV, SNLRP, SoRIP1, SoRIP2, stenodactylin, Stx, Stx type 1, Stx-1, Stx1, Stx1A, Stx2, Stx2A, Stx2dact, StxB, TCS, trichoanguin, trichomaglin, trichosanthin, Trichosanthrip, trichosnathin, TRIP, tritin-L, tritin-S, TYchi, type 1 ribosome inactivating protein, type 1 ribosome-inactivating protein, type 1 RIP, type 2 ribosome inactivating protein, type 2 ribosome-inactivating protein, type 2 RIP, type 2RIP, type 3 RIP, type I ribosome inactivating protein, type I ribosome-inactivating protein, type I RIP, type II ribosome inactivating protein, type II ribosome-inactivating protein, type II RIP, type III ribosome-inactivating protein, type III RIP, type-1 ribosome-inactivating protein, type-1 RIP, type-2 ribosome-inactivating protein, type-2 RIP, VAA-I, viscinum, Viscum album agglutinin I, viscumin, volkensin
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3.2.2.22 rRNA N-glycosylaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.2.2.22 - rRNA N-glycosylase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
adenosine in rRNA + H2O
deadenylated rRNA + adenine
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rRNA is depurinated thus producing inactive ribosomes and inhibition protein synthesis probably due to the lack of the interaction between depurinated ribosomes and elongation factor 2
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-
?
brome mosaic virus RNA + H2O
?
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depurination of the viral RNA, anti-viral activity of PAP by inhibition of accumulation of viral RNA and viral proliferation in barley protoplasts, overview
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-
?
RNA + H2O
?
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the enzyme is active on viral RNA, e.g. from Human immunodeficiency virus-1 and Brome mosaic virus, RNA accession mechanism via interaction with translation initiation factors 4G and iso4G, overview
-
-
?
tobacco mosaic virus RNA + H2O
?
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SNA-I, SNA-V, and SNLRP show anti-viral activity
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-
?
28S rRNA + H2O
28S rRNA fragment + ?
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depurination at A4324, removal of adenine from rRNA, inactivating ribosomal function in translation
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-
?
28S rRNA + H2O
28S rRNA fragment + ?
depurination or 28S rRNA, removal of adenine from rRNA, inactivating ribosomal function in translation
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-
?
28S rRNA + H2O
?
inactivation of protein translation in targeted cells, e.g. bacterial cells, where the toxin is transported into the cytosol
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-
?
28S rRNA + H2O
?
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saporin is a type I ribosome-inactivating protein with N-glycosidase activity. It removes adenine residues from the 28S ribosomal RNA resulting in inhibition of protein synthesis
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-
?
28S rRNA + H2O
apurinic 28S rRNA + adenine
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depurination of a specific adenine in 28S rRNA
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-
?
28S rRNA + H2O
apurinic 28S rRNA + adenine
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depurination of a specific adenine in 28S rRNA
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-
?
28S rRNA + H2O
apurinic 28S rRNA + adenine
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depurination of a specific adenine in 28S rRNA
-
-
?
large rRNA + H2O
?
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the enzyme highly inhibits protein synthesis by ribosome inactivation via depurination of rRNA at a specific site
-
-
?
large rRNA + H2O
?
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the enzyme highly inhibits protein synthesis by ribosome inactivation via depurination of rRNA at a specific site
-
-
?
large rRNA + H2O
?
-
the enzyme highly inhibits protein synthesis by ribosome inactivation via depurination of rRNA at a specific site
-
-
?
large rRNA + H2O
?
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the enzyme highly inhibits protein synthesis by ribosome inactivation via depurination of rRNA at a specific site
-
-
?
large rRNA + H2O
?
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the enzyme highly inhibits protein synthesis by ribosome inactivation via depurination of rRNA at a specific site
-
-
?
large rRNA + H2O
?
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the enzyme highly inhibits protein synthesis by ribosome inactivation via depurination of rRNA at a specific site
-
-
?
large rRNA + H2O
?
-
the enzyme highly inhibits protein synthesis by ribosome inactivation via depurination of rRNA at a specific site
-
-
?
large rRNA + H2O
?
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the enzyme highly inhibits protein synthesis by ribosome inactivation via depurination of rRNA at a specific site
-
-
?
large rRNA + H2O
?
inhibition of translation and protein synthesis, cytotoxic
-
-
?
rRNA + H2O
?
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abrin plays an important role in the early development of immunology
-
-
?
rRNA + H2O
?
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believed to protect the seeds they inhabit against plant-eating organisms like phytophagous invertebrates and herbivorous animals
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-
?
rRNA + H2O
?
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cannot inactivate its own autologous ribosome, RIPs are less efficient on plant than on mammalian ribosomes and on naked RNA than on intact ribosomes
-
-
?
rRNA + H2O
?
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inhibits mechanical transmission of plant viruses such as tobacco mosaic virus
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-
?
rRNA + H2O
?
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depurination of the sarcin-ricin loop of eukaryotic large rRNA
-
-
?
rRNA + H2O
?
PAP causes translation arrest and is cytotoxic in targeted cells
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-
?
rRNA + H2O
?
-
-
-
-
?
rRNA + H2O
?
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believed to protect the seeds they inhabit against plant-eating organisms like phytophagous invertebrates and herbivorous animals
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-
?
rRNA + H2O
?
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PAP causes translation arrest and is cytotoxic in targeted eukaryotic cells
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-
?
rRNA + H2O
?
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physiological role of RIPs in plants may be to defense against pathogens
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-
?
rRNA + H2O
?
inhibition of translation and protein synthesis, cytotoxic
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-
?
additional information
?
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the cytotoxic enzyme irreversibly inactivates eukaryotic ribosomes in target cells, e.g. Sp2/0 cells and SMMC-7721 cells, by depurinating a key adenine residue from a highly conserved GAGA loop in 28S rRNA thereby inhibiting protein synthesis
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-
?
additional information
?
-
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the enzyme binds specifically to terminal Gal and/or GalNAc of the target cell surface receptor
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-
?
additional information
?
-
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the enzyme inhibits protein synthesis of the targeted cells and is highly cytotoxic, abrin causes apoptosis
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-
?
additional information
?
-
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removal of specific adenine of ribosomal RNA
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-
?
additional information
?
-
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the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells
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-
?
additional information
?
-
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the enzyme inhibits protein synthesis of the targeted cells and is highly cytotoxic, high doses of modeccin are lethal e.g. in rats, retrograde transport of modeccin when injected in the central nervous system of mice
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-
?
additional information
?
-
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ribosome-inactivating proteins, RIPs, are specific RNA N-glycosidases and inhibit protein synthesis and induce cell death by removing a single adenine from a specific rRNA loop. Type 1 RIPs are single-chain enzymes with N-glycosidase activity. Type 2 RIPs contain two chains A and B linked by a disulfide bond. The A chain has RIP enzymatic activity, whereas the B chain shows lectin activity and is able to bind to glycosylated receptors on the cell surface. Stenodactylin is a type 2 RIP
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-
?
additional information
?
-
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the enzyme binds specifically to terminal Gal of the target cell surface receptor
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-
?
additional information
?
-
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the enzyme inhibits protein synthesis of the targeted cells and is highly cytotoxic, high doses of volkensin are lethal e.g. in rats, retrograde transport of modeccin when injected in the central nervous system of mice
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-
?
additional information
?
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the enzyme inhibits the target cell protein synthesis and causes apoptosis, interaction of volkensin with HeLa cells: binding to cell surface receptors, uptake by endocytosis and accumulation, intracellular localization in the Golgi apparatus and translocation via endoplamic reticulum into the cytosol, degradation and exocytosis, overview
-
-
?
additional information
?
-
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the cytotoxic enzyme induces apoptosis in transformed cells by inhibiting protein synthesis and inactivating ribosomes, the enzyme targets diverse cells, overview
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-
?
additional information
?
-
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CAP30 exhibits antibacterial activity and is induced in case of infection or wounding
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-
?
additional information
?
-
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the cytotoxic enzyme inhibits protein synthesis of the targeted BA/F3beta cells, the cytotoxicity is low compared to ricin of Ricinus communis due to the low affinity of the B-chain subunit for the cell surface ligands
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-
?
additional information
?
-
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the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells
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-
?
additional information
?
-
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pentameric B subunit binds to its cell surface receptor Gb3 for toxin internalization, and the A subunit follows intracellular retrograde transport to the cytosol where its RNA N-glycosidase activity shuts down the protein synthesis, and leads to cell death
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-
?
additional information
?
-
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the enzyme shows antifungal activity and inactivates fungal ribosomes, which is increased by association with glucanase and chitinase facilitating the entry of RIP
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-
?
additional information
?
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Iris sp.
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IRAb shows strong local antiviral activity against the tobacco mosaic virus, but cannot confersystemic protection against viruses, e.g. the tobacco etch virus
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-
?
additional information
?
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Iris sp.
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IRIP shows strong local antiviral activity against the tobacco mosaic virus, but cannot confer systemic protection against viruses, e.g. the tobacco etch virus
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-
?
additional information
?
-
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MAP shows antifungal activity and inactivates fungal ribosomes
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-
?
additional information
?
-
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the enzyme binds specifically to terminal Gal and GalNAc of the target cell surface receptor, preferring Gal
-
-
?
additional information
?
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enzyme inhibits the growth of the fungus Sphaerotheca fuliginea in vitro
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-
?
additional information
?
-
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enzyme inhibits the growth of the fungus Sphaerotheca fuliginea in vitro
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-
?
additional information
?
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depurination of rRNA, N-glycosidase activity, oxidative and genotoxic action on butterfly third instar larvae Anticarsia gemmatalis (soybean caterpillar) and Spodoptera frugiperda (fall armyworm) of the lepidopteran family Noctuidae
-
-
?
additional information
?
-
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ribosome-inactivating proteins, RIPs, are a family of enzymes that depurinate rRNA and inhibit protein biosynthesis
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-
?
additional information
?
-
-
enzyme shows strong inhibitory activity on protein synthesis in rabbit cell-free reticulocyte lysate system with IC50 value of 0.36nM. Enzyme is cytotoxic. IC50 values of Cochinin B are 16.9, 114 and 574 nM for human cervical epithelial carcinoma cell, HEK 293 and NCI-H187 cell, respectively
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-
?
additional information
?
-
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the enzyme inhibits translation of rabbit reticulocytes and wheat germ lysate, the enzyme shows anti-microbial activity, e.g. against Trichoderma reesei, Ervinia amylovora, Shigella asonei, Salmonella typhimurium, Rhizobium leguminosarum, Cytospora cankar, and Pseudomonas solancearum, overview
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-
?
additional information
?
-
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the enzyme inhibits protein synthesis of the targeted cells and is highly cytotoxic
-
-
?
additional information
?
-
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anti-viral activity of PAP in CBA mice infected with lymphocytic choriomeningitis virus, LCMV strain WE54, inoculated by intracerebral injections, overview, anti-viral activity against HIV-1 in human peripheral blood mononuclear cells infected with strain HIV-1 HLTVIIIB, IC50p24 is 14 nM
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-
?
additional information
?
-
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PAP shows high antiviral activity against both plant and animal viruses, mechanism study, viral particles are not attacked directly, the ribosome inactivation is not essential for antiviral effectivity, PAP acts as immunotoxin, overview
-
-
?
additional information
?
-
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depurination of rRNA, N-glycosidase activity, oxidative and genotoxic action on butterfly third instar larvae Anticarsia gemmatalis (soybean caterpillar) and Spodoptera frugiperda (fall armyworm) of the lepidopteran family Noctuidae
-
-
?
additional information
?
-
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PAP shows RNA N-glycosidase activity towards eukaryotic and prokaryotic ribosomes, karasurin-A only towards eukaryotic ribosomes, removal of specific adenine from alpha-sarcin/ricin loop of the large rRNA, substrate specificity (eukaryotic/prokaryotic) determined by C-terminus residues 209-225
-
-
?
additional information
?
-
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removal of adenine from rRNA, inactivating ribosomal function in translation
-
-
?
additional information
?
-
removal of adenine from rRNA, inactivating ribosomal function in translation
-
-
?
additional information
?
-
removal of adenine from rRNA, inactivating ribosomal function in translation
-
-
?
additional information
?
-
-
removal of adenine from rRNA, inactivating ribosomal function in translation
-
-
?
additional information
?
-
ricin biosynthesis, overview, ricin acts also on the endogenous ribosomes and is thus localized in vacuoles in seeds, the enzyme binds specifically to terminal Gal and GalNAc of target cell surface components, target cells are mammalian cells, the toxin enters by binding to the target cell surface followed by endocytosis and retrograde transport via the Golgi apparatus to the endoplasmic reticulum where the active part is set free and membrane translocated to the cytosol dependent on several factors, in the cytosol the toxin attacks the rRNA via interaction with the sarcin-ricin domain of the large ribosome, inhibiting the ribosomes, and leading to apoptosis, different mechanism of endocytosis are possible, detailed overview
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-
?
additional information
?
-
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ricin or the catalytic A-chain are highly cytotoxic
-
-
?
additional information
?
-
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the cytotoxic enzyme inhibits protein synthesis of the targeted BA/F3beta cells, the cytotoxicity is high compared to cinnamomin of Cinnamomum camphora due to the high affinity of the B-chain subunit for the cell surface ligands
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-
?
additional information
?
-
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the enzyme induces cytokinins, e.g. interleukin-8, the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells, the enzyme targets the cell surface of the target cell followed by endocytosis and transport to the endoplasmic reticulum where the active part is set free and translocated to the cytosol dependent on several factors, in the cytosol the toxin attacks its target
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-
?
additional information
?
-
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the enzyme inhibits protein synthesis of the targeted cells and is highly cytotoxic and causes apoptosis, high doses of ricin are lethal e.g. in rats, ricin enters the targeted cell by endocytosis, is cleaved in the endoplasmic reticulum/Golgi and retrograde transported to the cytosol, ricin is transported along nerves in rats, ricin A-chain shows antifungal activity and inactivates fungal ribosomes, ricin is strongly immunogenic and acts as immunotoxin, overview, ricin causes disruption of human umbilical endothelial cell DNA before activation of caspase 3
-
-
?
additional information
?
-
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the enzyme is a cytotoxin inhibiting protein synthesis and DNA lesions repair in human cells and causing apoptosis, in addition, the enzyme causes DNA lesions in human umbilical vein endothelial cells, overview
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-
?
additional information
?
-
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the wild-type holotoxin ricin is lethal for the target cell, e.g. Verocells, due to inactivation of ribosomes and inhibition of protein synthesis
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-
?
additional information
?
-
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ricin A-chain can inactivate eukaryotic ribosomes, but exhibits no N-glycosidase activity on intact Escherichia coli ribosomes
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-
?
additional information
?
-
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ricin inhibits translation by removal of a specific adenine from 28S RNA, all seven full-length ricin family members are active
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-
?
additional information
?
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RTA catalyzes adenosine depurination of 28S rRNA to inhibit protein synthesis and cause cell death
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-
?
additional information
?
-
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the enzyme binds specifically to terminal N-acetylneuramic acid of the target cell surface receptor
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-
?
additional information
?
-
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isozyme SNAV, i.e. nigrin b, binds specifically to terminal GalNAc or to a lesser extent to Gal, while isozymes SNAI and SNAIf bind preferably to terminal N-acetylneuramic acid of the target cell surface receptor
-
-
?
additional information
?
-
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the enzyme inhibits the target cell protein synthesis and causes apoptosis, interaction of nigrin b with HeLa cells: binding to cell surface receptors, uptake by endocytosis and accumulation, intracellular localization in the Golgi apparatus and translocation via endoplamic reticulum into the cytosol, degradation and exocytosis, overview
-
-
?
additional information
?
-
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the Sambucus nigra agglutinins, including isozyme nigrin B, are non-cytotoxic type 2 RIPs, eventhough they shows high cell entry and enzyme activity rates, due to rapid degradation and excretion from the targeted cells, nigrin b causes gut derangement in mice at high doses
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-
?
additional information
?
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doses of more than 100 microg/ml SNA-I fed to pea aphids are toxic: LC50 = 374 microg/ml, doses of 100 and 50 microg/ml SNA-I reduce fecundity of pea aphids by about 70% and 43%, respectively, reduced survival and fecundity of adult tobacco aphids feeding on transgenic single SNA-I mutant tobacco plants (Nicotiana tabacum cv Samsun NN), not on double mutants that have no effect comparable to control plants that do not express SNA-I
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?
additional information
?
-
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saporin-S6 shows antifungal activity and inactivates fungal ribosomes, saporin can cause apoptosis and acts as immunotoxin, overview
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-
?
additional information
?
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the conjugate of the drug Rituximab with saporin-S6 completely inhibits clonogenic growth of CD20-expressing Raji cells, by inhibiting of protein synthesis, and produces a synergistic toxic effect with the drug Fludarabine, the enzyme is cytotoxic and immunotoxic, and causes e.g. apoptosis in cells of patiets treated with B-cell non-Hodgekin's lymphoma therapy, NHL
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?
additional information
?
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depurination of rRNA, N-glycosidase activity, oxidative and genotoxic action on butterfly third instar larvae Anticarsia gemmatalis (soybean caterpillar) and Spodoptera frugiperda (fall armyworm) of the lepidopteran family Noctuidae
-
-
?
additional information
?
-
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depurination of the ribosomal sarcin-ricin tetraloop, GAGA, causing inhibition of protein synthesis and cellular death. Saporin-L1 shows robust activity against defined nucleic acid substrates and mammalian ribosomes, saporin-S6 shows low activity
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-
?
additional information
?
-
SAP catalyzes adenosine depurination of 28S rRNA to inhibit protein synthesis and cause cell death
-
-
?
additional information
?
-
-
the enzyme induces cytokinins, e.g. interleukin-8, the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells, the enzyme targets the cell surface of the target cell followed by endocytosis and transport to the endoplasmic reticulum where the active part is set free and translocated to the cytosol dependent on several factors, in the cytosol the toxin attacks its target
-
-
?
additional information
?
-
-
the enzyme inhibits protein synthesis of the targeted cells and is highly cytotoxic, Shiga toxin causes disruption of human umbilical endothelial cell DNA before activation of caspase 3
-
-
?
additional information
?
-
-
the enzyme is a cytotoxin inhibiting protein synthesis and DNA lesions repair in human cells and causing apoptosis, in addition, the enzyme causes DNA lesions in human umbilical vein endothelial cells, overview
-
-
?
additional information
?
-
-
depurination of rRNA, N-glycosidase activity, oxidative and genotoxic action on butterfly third instar larvae Anticarsia gemmatalis (soybean caterpillar) and Spodoptera frugiperda (fall armyworm) of the lepidopteran family Noctuidae
-
-
?
additional information
?
-
-
the enzyme displays N-glycosidase activity causing specific rRNA depurination. It has antifungal and cytotoxic effects and inhibits cell growth, overview
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-
?
additional information
?
-
-
depurination of rRNA, N-glycosidase activity, oxidative and genotoxic action on butterfly third instar larvae Anticarsia gemmatalis (soybean caterpillar) and Spodoptera frugiperda (fall armyworm) of the lepidopteran family Noctuidae
-
-
?
additional information
?
-
-
trichosanthin is immunogenic and leads to IgE production in humans, Trichosanthes kirilowii root tubers containing trichosanthin causes abortion, overview
-
-
?
additional information
?
-
depurination of specific adenine at sarcin-ricin loop of 28S rRNA, preventing the binding of elongation factors to the GTPase activation centre of the ribosome
-
-
?
additional information
?
-
karasurin-A shows RNA N-glycosidase activity only towards eukaryotic ribosomes while pokeweed antiviral protein is active towards eukaryotic and prokaryotic ribosomes, removal of specific adenine from alpha-sarcin/ricin loop of the large rRNA, substrate specificity (eukaryotic/prokaryotic) determined by C-terminus residues 209-225
-
-
?
additional information
?
-
-
the enzyme binds specifically to terminal Gal and GalNAc of the target cell surface receptor
-
-
?
additional information
?
-
-
the enzyme inhibits protein synthesis of the targeted cells and is highly cytotoxic, viscumin causes apoptosis
-
-
?
additional information
?
-
the isozyme RIP1 has defense-related function in maize plants
-
-
?
additional information
?
-
-
the isozyme RIP1 has defense-related function in maize plants
-
-
?
additional information
?
-
-
the isozyme RIP1 has defense-related function in maize plants
-
-
?
additional information
?
-
the isozyme RIP1 has defense-related function in maize plants
-
-
?
additional information
?
-
-
the isozyme RIP2 has defense-related function in maize plants
-
-
?
additional information
?
-
the isozyme RIP2 has defense-related function in maize plants
-
-
?
