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Literature summary for 3.2.2.22 extracted from
- Ricin A-chain activity on stem-loop and unstructured DNA substrates (2005), Biochemistry, 44, 4416-4425.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics of ricin A-chain with stem-loop and unstructured DNA substrates, overview | Ricinus communis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Ricinus communis | ricin or the catalytic A-chain are highly cytotoxic | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ricinus communis | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| seed | - |
Ricinus communis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 28S rRNA + H2O | of eukaryotic ribosomes, generation of an R-fragment from 28S RNA, depurination of a single adenylate on a GAGA stem-loop region | Ricinus communis | ? | - |
? | |
| additional information | ricin or the catalytic A-chain are highly cytotoxic | Ricinus communis | ? | - |
? | |
| additional information | ricin A-chain activity on stem-loop and unstructured DNA substrates, structural requirements for activity, stem and tetraloop structures are essential, overview | Ricinus communis | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | heterodimer formed by a catalytic subunit A, RTA, and a carbohydrate binding subunit B, RTB | Ricinus communis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ricin | - |
Ricinus communis |
| type II ribosome-inactivating protein | - |
Ricinus communis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
pH-dependency with stem-loop and unstructured DNA substrates, overview | Ricinus communis |
| 8 | - |
assay at | Ricinus communis |
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Release 2023.1 (January 2023)
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