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Literature summary for 3.2.2.22 extracted from

  • Polito, L.; Bolognesi, A.; Tazzari, P.L.; Farini, V.; Lubelli, C.; Zinzani, P.L.; Ricci, F.; Stirpe, F.
    The conjugate Rituximab/saporin-S6 completely inhibits clonogenic growth of CD20-expressing cells and produces a synergistic toxic effect with Fludarabine (2004), Leukemia, 18, 1215-1222.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saponaria officinalis the conjugate of the drug Rituximab with saporin-S6 completely inhibits clonogenic growth of CD20-expressing Raji cells, by inhibiting of protein synthesis, and produces a synergistic toxic effect with the drug Fludarabine, the enzyme is cytotoxic and immunotoxic, and causes e.g. apoptosis in cells of patiets treated with B-cell non-Hodgekin's lymphoma therapy, NHL ?
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Organism

Organism UniProt Comment Textmining
Saponaria officinalis
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isozyme saporin-S6
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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cell-free protein synthesis inhibition activity of free and conjugated RIP Saponaria officinalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the conjugate of the drug Rituximab with saporin-S6 completely inhibits clonogenic growth of CD20-expressing Raji cells, by inhibiting of protein synthesis, and produces a synergistic toxic effect with the drug Fludarabine, the enzyme is cytotoxic and immunotoxic, and causes e.g. apoptosis in cells of patiets treated with B-cell non-Hodgekin's lymphoma therapy, NHL Saponaria officinalis ?
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?
ribosome + H2O inhibition of protein synthesis in rabbit reticulocyte lysate by depurination of rRNA Saponaria officinalis ?
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Synonyms

Synonyms Comment Organism
saporin-S6
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Saponaria officinalis