Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Saponaria officinalis | the conjugate of the drug Rituximab with saporin-S6 completely inhibits clonogenic growth of CD20-expressing Raji cells, by inhibiting of protein synthesis, and produces a synergistic toxic effect with the drug Fludarabine, the enzyme is cytotoxic and immunotoxic, and causes e.g. apoptosis in cells of patiets treated with B-cell non-Hodgekin's lymphoma therapy, NHL | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saponaria officinalis | - |
isozyme saporin-S6 | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
cell-free protein synthesis inhibition activity of free and conjugated RIP | Saponaria officinalis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the conjugate of the drug Rituximab with saporin-S6 completely inhibits clonogenic growth of CD20-expressing Raji cells, by inhibiting of protein synthesis, and produces a synergistic toxic effect with the drug Fludarabine, the enzyme is cytotoxic and immunotoxic, and causes e.g. apoptosis in cells of patiets treated with B-cell non-Hodgekin's lymphoma therapy, NHL | Saponaria officinalis | ? | - |
? | |
ribosome + H2O | inhibition of protein synthesis in rabbit reticulocyte lysate by depurination of rRNA | Saponaria officinalis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
saporin-S6 | - |
Saponaria officinalis |