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Literature summary for 3.2.2.22 extracted from

  • Jeong, K.; Chapman-Bonofiglio, S.; Singh, P.; Lee, J.; Tzipori, S.; Sheoran, A.
    In vitro and in vivo protective efficacies of antibodies that neutralize the RNA N-glycosidase activity of Shiga toxin 2 (2010), BMC Immunol., 11, 16-24.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
additional information ability of 19 Stx2 A subunit-specific human monoclonal antibodies to neutralize the RNA N-glycosidase activity, and the correlation of this neutralizing activity with protection of HeLa cells and mice against Stx2-induced death, overview Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli pentameric B subunit binds to its cell surface receptor Gb3 for toxin internalization, and the A subunit follows intracellular retrograde transport to the cytosol where its RNA N-glycosidase activity shuts down the protein synthesis, and leads to cell death ?
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 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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 a Shiga toxin-producing strain
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information pentameric B subunit binds to its cell surface receptor Gb3 for toxin internalization, and the A subunit follows intracellular retrograde transport to the cytosol where its RNA N-glycosidase activity shuts down the protein synthesis, and leads to cell death Escherichia coli ?
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 ?

Subunits

Subunits Comment Organism
pentamer one of two Stx liberated by Stx-producing Escherichia coli is composed of an A subunit monomer and a B subunit pentamer Escherichia coli

Synonyms

Synonyms Comment Organism
RNA N-glycosidase
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 Escherichia coli
RNA-NGA
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 Escherichia coli
Shiga toxin 2
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 Escherichia coli
Stx2
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 Escherichia coli

General Information

General Information Comment Organism
malfunction infection with Shiga toxin-producing Escherichia coli is the most significant cause of hemolytic uremic syndrome in humans, the leading cause of acute renal failure in children Escherichia coli