Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | ability of 19 Stx2 A subunit-specific human monoclonal antibodies to neutralize the RNA N-glycosidase activity, and the correlation of this neutralizing activity with protection of HeLa cells and mice against Stx2-induced death, overview | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Escherichia coli | pentameric B subunit binds to its cell surface receptor Gb3 for toxin internalization, and the A subunit follows intracellular retrograde transport to the cytosol where its RNA N-glycosidase activity shuts down the protein synthesis, and leads to cell death | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
a Shiga toxin-producing strain | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | pentameric B subunit binds to its cell surface receptor Gb3 for toxin internalization, and the A subunit follows intracellular retrograde transport to the cytosol where its RNA N-glycosidase activity shuts down the protein synthesis, and leads to cell death | Escherichia coli | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
pentamer | one of two Stx liberated by Stx-producing Escherichia coli is composed of an A subunit monomer and a B subunit pentamer | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
RNA N-glycosidase | - |
Escherichia coli |
RNA-NGA | - |
Escherichia coli |
Shiga toxin 2 | - |
Escherichia coli |
Stx2 | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
malfunction | infection with Shiga toxin-producing Escherichia coli is the most significant cause of hemolytic uremic syndrome in humans, the leading cause of acute renal failure in children | Escherichia coli |