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Literature summary for 3.2.2.22 extracted from

  • Endo, Y.; Tsurugi, K.
    The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA (1988), J. Biol. Chem., 263, 8735-8739.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0026
-
rRNA pH 7.6, 37°C, rat liver 80S ribosome Ricinus communis
0.0033
-
rRNA pH 7.6, 37°C, Escherichia coli naked 23 S rRNA Ricinus communis
0.0058
-
rRNA pH 7.6, 37°C, rat liver naked 28 S rRNA Ricinus communis

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
rRNA + H2O Ricinus communis
-
?
-
?

Organism

Organism UniProt Comment Textmining
Ricinus communis
-
castor bean
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no effect on 23S rRNA in Escherichia coli ribosomes, N-glycosidic bond is cleaved in naked 23S rRNA, also acts on naked 16S rRNA, cleaves the N-glycosidic bond of adenine at position 1014 Ricinus communis ?
-
?
additional information damages eukaryotic ribosomes by cleaving the N-glycosidic bond at A4324 of the 28 S rRNA Ricinus communis ?
-
?
rRNA + H2O
-
Ricinus communis ?
-
?
rRNA + H2O cleaves the N-glycosidic bond and removes adenine at A-4324 in 28 S rRNA when intact rat ribosomes are the substrate, cleaves the same N-glycosidic bond in naked 28 S rRNA Ricinus communis ?
-
?

Synonyms

Synonyms Comment Organism
ricin A-chain
-
Ricinus communis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.000333
-
rRNA pH 7.6, 37°C, rat liver naked 28 S rRNA Ricinus communis
0.0005
-
rRNA pH 7.6, 37°C, Escherichia coli naked 23 S rRNA Ricinus communis
29.6
-
rRNA pH 7.6, 37°C, rat liver 80S ribosome Ricinus communis