Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Ricinus communis | the enzyme is a cytotoxin inhibiting protein synthesis and DNA lesions repair in human cells and causing apoptosis, in addition, the enzyme causes DNA lesions in human umbilical vein endothelial cells, overview | ? | - |
? | |
additional information | Shigella dysenteriae | the enzyme is a cytotoxin inhibiting protein synthesis and DNA lesions repair in human cells and causing apoptosis, in addition, the enzyme causes DNA lesions in human umbilical vein endothelial cells, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ricinus communis | - |
- |
- |
Shigella dysenteriae | - |
isozyme Stx1 | - |
Purification (Comment) | Organism |
---|---|
native enzyme from seeds | Ricinus communis |
recombinant Stx1 expressed in Escherichia coli | Shigella dysenteriae |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
seed | - |
Ricinus communis | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Ricinus communis |
additional information | - |
- |
Shigella dysenteriae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is a cytotoxin inhibiting protein synthesis and DNA lesions repair in human cells and causing apoptosis, in addition, the enzyme causes DNA lesions in human umbilical vein endothelial cells, overview | Ricinus communis | ? | - |
? | |
additional information | the enzyme is a cytotoxin inhibiting protein synthesis and DNA lesions repair in human cells and causing apoptosis, in addition, the enzyme causes DNA lesions in human umbilical vein endothelial cells, overview | Shigella dysenteriae | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | heterodimer formed by a catalytic subunit A and a carbohydrate binding subunit B | Shigella dysenteriae |
dimer | heterodimer formed by a catalytic subunit A, RTA, and a carbohydrate binding subunit B, RTB | Ricinus communis |
Synonyms | Comment | Organism |
---|---|---|
ricin | - |
Ricinus communis |
Shiga toxin 1 | - |
Shigella dysenteriae |
Stx1 | - |
Shigella dysenteriae |
type II ribosome-inactivating protein | - |
Ricinus communis |
type II ribosome-inactivating protein | - |
Shigella dysenteriae |
type II RIP | - |
Ricinus communis |
type II RIP | - |
Shigella dysenteriae |