3.2.2.22: rRNA N-glycosylase
This is an abbreviated version!
For detailed information about rRNA N-glycosylase, go to the full flat file.
Word Map on EC 3.2.2.22
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3.2.2.22
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checkpoint
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immunotherapy
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lymphocyte
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death-ligand
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nsclc
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non-small
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t-cells
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tumor-infiltrating
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clinicopathological
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immunotoxins
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subtypes
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cd8
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pembrolizumab
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melanoma
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adenocarcinoma
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progression-free
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death-1
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ligand-1
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resect
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lymphoma
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toxin-producing
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anti-pd-1
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dendritic
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uremic
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nivolumab
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monotherapy
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durable
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hemolytic
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first-line
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ctla-4
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urothelial
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tregs
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intratumoral
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evasion
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immune-related
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non-small-cell
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immunotherapeutic
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diarrhea
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treatment-related
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alk
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second-line
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platinum-based
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castor
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myeloid-derived
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shigella
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neoadjuvant
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foxp3
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cytotoxin
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serogroups
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agriculture
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biotechnology
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nutrition
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medicine
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pharmacology
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diagnostics
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analysis
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recist
- 3.2.2.22
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checkpoint
-
immunotherapy
- lymphocyte
-
death-ligand
-
nsclc
-
non-small
- t-cells
-
tumor-infiltrating
-
clinicopathological
- immunotoxins
- subtypes
- cd8
-
pembrolizumab
- melanoma
- adenocarcinoma
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progression-free
-
death-1
- ligand-1
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resect
- lymphoma
-
toxin-producing
-
anti-pd-1
- dendritic
-
uremic
-
nivolumab
-
monotherapy
-
durable
-
hemolytic
-
first-line
-
ctla-4
-
urothelial
-
tregs
-
intratumoral
-
evasion
-
immune-related
-
non-small-cell
-
immunotherapeutic
-
diarrhea
-
treatment-related
- alk
-
second-line
-
platinum-based
- castor
-
myeloid-derived
- shigella
-
neoadjuvant
- foxp3
-
cytotoxin
-
serogroups
- agriculture
- biotechnology
- nutrition
- medicine
- pharmacology
- diagnostics
- analysis
-
recist
Reaction
Synonyms
(ribosome-inactivating protein)-like protein, abelesculin, ABRaA, abrin, abrin-a A chain, Abrus precatorius agglutinin, alpha-MC, alpha-momorcharin, alpha-pisavin, antiviral protein DAP-30, aralin, B-32, balsamin, BBAP1, BE27, beta-momorcharin, beta-pisavin, Bougainvillea xbuttiana antiviral protein 1, bouganin, camphorin, CAP30, cinnamomin, Cochinin B, cytotoxic ribosome-inactivating lectin, D6D54_07625, D6D54_08385, D6D54_08880, depurinating rRNA N-glycosidase, dianthin 30, dianthin 32, dianthin-30, diphtheria toxin, ebulin b, ebulitin alpha, ebulitin beta, ebulitin gamma, gelonin, gysophilin, hispin, IRAb, IRIP, Iris agglutinin b, Iris ribosome-inactivating protein, JIP60, karasurin-A, KML, lamjapin, luffaculin I, luffin P1, lychnin, MAP, marmorin, ME1, Mirabilis antiviral protein, mistletoe lectin I, mistletoe lectin II, mistletoe lectin III, ML-I, MLI, MLII, MLIII, MOD, modeccin, momorcochin, momorcochin-S, momordin, momordin I, momordin II, momorgrosvin, More, N-glycosidase, n-TCS, neo-trichosanthin, nigrin b, nigritin f1, nigritin f2, PAG, PAGase, PAP, PAP-I, PAP-II, PAP-III, PAP-R, PAP-S, PD-L, PD-L1, PD-L4, pepocin, PGase, pokeweed anti-viral protein, pokeweed antiviral protein, polynucleotide:adenosine glycosidase, polynucleotide:adenosine glycosylase, porrectin, RA, RCA-II, ribosomal inactivating protein, ribosomal ribonucleate N-glycosidase, ribosome inactivating protein, ribosome-inactivating protein, ribosome-inactivating protein 3, ribosome-inactivating protein type II, ribosome-inactivating proteins, ribosome-inactivating type II protein, ribosome-specific N-glycosidase, ricin, ricin A, ricin A chain, ricin A-chain, ricin toxin A-chain, ricin-A-chain, ricin-like protein, Ricinus communis agglutinin, Ricinus communis agglutinin II, RIP, RIP-1, RIP1, RIP2, RIPII, riproximin, RLP1, RLP2, RLP3, RLP4, RLP5, RLP6, RNA N-glycosidase, RNA-NGA, RNA-specific N-glycosidase, RNase Bo, Rpx, rRNA N-glycosidase, RTA, Sambucus nigra agglutinin, Sambucus nigra agglutinin I, SAP, saporin, saporin 6, saporin S-6, saporin S6, saporin-6, saporin-L1, saporin-S6, saporins, SBA, SCO7092, SEPIN, Shiga toxin, Shiga toxin 1, Shiga toxin 1 subunit A, Shiga toxin 2, Shiga toxin 2 subunit A, Shiga toxin type 1, Shiga toxin type 2, Shiga toxin-1, shiga-like toxin, shiga-like toxin I, sieboldin-b, single-chain ribosome-inactivating protein, SLT-I, SLT-II, SLT-IIv, SNA, SNA-I, SNA-V, SnaI, SNAIf, SNAV, SNLRP, SoRIP1, SoRIP2, stenodactylin, Stx, Stx type 1, Stx-1, Stx1, Stx1A, Stx2, Stx2A, Stx2dact, StxB, TCS, trichoanguin, trichomaglin, trichosanthin, Trichosanthrip, trichosnathin, TRIP, tritin-L, tritin-S, TYchi, type 1 ribosome inactivating protein, type 1 ribosome-inactivating protein, type 1 RIP, type 2 ribosome inactivating protein, type 2 ribosome-inactivating protein, type 2 RIP, type 2RIP, type 3 RIP, type I ribosome inactivating protein, type I ribosome-inactivating protein, type I RIP, type II ribosome inactivating protein, type II ribosome-inactivating protein, type II RIP, type III ribosome-inactivating protein, type III RIP, type-1 ribosome-inactivating protein, type-1 RIP, type-2 ribosome-inactivating protein, type-2 RIP, VAA-I, viscinum, Viscum album agglutinin I, viscumin, volkensin
ECTree
3.2.2.22 rRNA N-glycosylaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 3.2.2.22 - rRNA N-glycosylase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
((5-(2-amino-4,6-dihydroxy-5-pyrimidinyl)pentanoyl)amino)acetic acid
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(E)-3-(5-methylfuran-2-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)prop-2-enamide
CID 16271106, a group III compound, dose-dependent inhibition of ricin activity, mildly or moderately cytotoxic
2-amino-1,4-dihydro-6-hydroxy-4-oxo-a-phenyl-pyrimidinepentanoic acid
PPA
2-amino-4-oxo-3,4-dihydro-pteridine 7-carbohydrazide
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35% inhibition at 0.5 mM
2-methylsulfonyl-1-(naphthalen-1-ylmethyl)benzimidazole
CID 18576762, a group III compound, dose-dependent inhibition of ricin activity, mildly or moderately cytotoxic
4-(3-(2-amino-1,4-dihydro-6-hydroxy-4-oxo-5-pyrimidinyl)propyl)-benzoic acid
PBA
4-bromo-2-[6-[(2,6-dimethylphenyl)amino]-3H-imidazo[1,2-b][1,2,4]triazol-5-yl]phenol
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7-bromo-5-phenyl-4-propanoyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one
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8-vinyl-2'-deoxyadenosine containing 10-mer stem-tetraloop RNA
i.e. 8VdA-10, active site analogue, no substrate. Role of residue R180 in oxacarbenium ion destabilization, adenine is released from a second site within the molecule
beta-methyl galactoside
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50% inhibition of ricin binding to immobilized asialofetuin in ELIZA-type assay at 1.78 mM, 50% inhibition in ricin cytotoxicity at 6.7 mM
beta-methyl lactoside
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50% inhibition of ricin binding to immobilized asialofetuin in ELIZA-type assay at 0.55 mM, 50% inhibition in ricin cytotoxicity at 4.0 mM
D-galactose
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50% inhibition of ricin binding to immobilized asialofetuin in ELIZA-type assay at 1.39 mM, 50% inhibition in ricin cytotoxicity at 65 mM
galactose
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and derivatives, inhibits the incorporation of the enzyme into target cells via its cell surface receptor, and inhibits the inhibition of protein synthesis through the enzyme, minimum inhibition concentration is 3.3 mM
grape pomace extract
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i.e. grape skin extract, dilutions of 0.5 mg/ml extract, 200fold greater EC50 (50% effective concentration)
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grape seed extract
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dilutions of 0.5 mg/ml extract, 6700fold greater EC50(50% effective concentration)
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KEESEESDDDMGFGLFD
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peptide corresponding to the C-terminal 17 amino acids of human ribosomal proteins P1 and P2, inhibits the ribosome-inactivating function of A1 chain of shiga-like toxin 1
methyl 2-[(5E)-5-[[5-(azepan-1-yl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]propanoate
milk
competitively inhibits the biological activity of 1 ng/ml ricin. Milk does not inhibit ricin at concentrations of 10 or 100 ng/ml
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N-cyclohexyl-N-[(4-fluorophenyl)methyl]-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamide
CID 7531223
Na+
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reaction with poly(A) and hdpDNA only at low ionic strength, no activity at 0.45 M NaCl
puromycin
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prior incubation of ribosomes with puromycin inhibits both the binding and depurination by the enzyme
scFvC5
single chain fragment variable antibody, blocks interaction between trichosanthin K173, R174, and K177 residues and ribosomal P proteins protecting ribosomes from inactivation
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4,6-bis(propan-2-ylamino)-1,3,5-triazine-2-carbonitrile
CID 644401, a group III compound, dose-dependent inhibition of ricin activity, mildly or moderately cytotoxic
9-deazaadenine-9-methylene-N-hydroxypyrrolidine
transition state analogue inhibitors contraining 9-deazaadenine-9-methylene-N-hydroxypyrrolidine. The tight-binding inhibitors mimic the sarcin-ricin recognition loop of 28S rRNA and the dissociative ribocation transition state established for RTA catalysis. RTA has a unique purine-binding geometry with quadruple pi-stacking interactions between adjacent adenine and guanine bases and 2 conserved tyrosines. An arginine at one end of the pi-stack provides cationic polarization and enhanced leaving group ability to the susceptible adenine. Inhibition mechanism, overview
9-deazaadenine-9-methylene-N-hydroxypyrrolidine
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transition state analogue mimics of small oligonucleotide substrates of saporin-L1, e.g. A10 or A14 RNA or cyclic oxime GAGA, are powerful, slow-onset and tight-binding inhibitors when adenosine is replaced with the transition state mimic 9-deazaadenine-9-methylene-N-hydroxypyrrolidine. The inhibitors bind up to 40000fold tighter than RNA substrates and prevent saporin-L1 inhibition of rabbit reticulocyte translation. Saporin-S6 is resistant to inhibition by the compounds, overview
9-deazaadenine-9-methylene-N-hydroxypyrrolidine
transition state analogue inhibitors containing 9-deazaadenine-9-methylene-N-hydroxypyrrolidine. The tight-binding inhibitors mimic the sarcin-ricin recognition loop of 28S rRNA and the dissociative ribocation transition state. SAP has a unique purine-binding geometry with quadruple pi-stacking interactions between adjacent adenine and guanine bases and 2 conserved tyrosines. An arginine at one end of the pi-stack provides cationic polarization and enhanced leaving group ability to the susceptible adenine. Inhibition mechanism, overview
brefeldin A
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inhibits interleukin-8 induction by the enzymethrough inhibition of the toxin transport from Golgi to the cytosol, overview
brefeldin A
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inhibits interleukin-8 induction by the enzyme through inhibition of the toxin transport from Golgi to the cytosol, overview
lactose
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50% inhibition of ricin binding to immobilized asialofetuin in ELIZA-type assay at 0.74 mM, 50% inhibition in ricin cytotoxicity at 9.6 mM
methyl 2-[(5E)-5-[[5-(azepan-1-yl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]propanoate
CID 5737931, a group III compound, dose-dependent inhibition of ricin activity, mildly or moderately cytotoxic
methyl 2-[(5E)-5-[[5-(azepan-1-yl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]propanoate
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additional information
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7-[3-fluoro-4-aminophenyl-(4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-]pyrazol-3-yl))]-quinoline, i.e. DHP-2, a zipper sterile-alpha-motif kinase-specific inhibitor, blocks the SAP kinase activation induced by ricin or Shiga toxin, but is not inhibitory to the toxins
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additional information
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red wine concentrate (dilutions of 1 mg/ml) and caffeic acid (dilutions of 0.5 mg/ml) without inhibitory function in the assay
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additional information
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ability of 19 Stx2 A subunit-specific human monoclonal antibodies to neutralize the RNA N-glycosidase activity, and the correlation of this neutralizing activity with protection of HeLa cells and mice against Stx2-induced death, overview
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additional information
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the inhibition of Shiga toxin 2 by apple juice is reversible
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additional information
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competitive inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state
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additional information
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no inhibition of cell toxicity by Gb4- and Gb3-liposomes, and sucrose
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additional information
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construction of a recombinant human antibody rVHPT specifically recognizing the ricin A chain CDR3 loop using computer-aided rational design, three-dimensional binding structure with ricin A chain, molecular modeling, the antibody competitively inhibits ricin A chain activity and cytotoxicity, overview
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additional information
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construction of a chimeric antibody using variable region genes of anti-ricin monoclonal antibody 4C13 which can neutralize the toxicitiy of ricin, and human constant region genes. The chimeric antibody blocks ricin-induced cytotoxicity to SP2/0 cells
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additional information
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7-[3-fluoro-4-aminophenyl-(4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-]pyrazol-3-yl))]-quinoline, i.e. DHP-2, a zipper sterile-alpha-motif kinase-specific inhibitor, blocks the SAP kinase activation induced by ricin or Shiga toxin, but is not inhibitory to the toxins
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additional information
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coupling of galactose to the surface of dendrimers does not result in synergistic interactions
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additional information
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depurination shows strong salt sensitivity, mechanism of electrostatically facilitatetd ribosome targeting
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additional information
group I small-molecule compounds demonstrate relatively low ricin inhibitory activity and cytotoxicity, group II small-molecules consists of compounds that show relatively high ricin inhibitory activity at low concentrations, but high cytotoxicity
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additional information
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not inhibited by 7-carbamoylpterin, N-(3,4,5-trimethoxybenzyl)-7-carbamoylpterin, and 7-(p-methoxybenzoyl)pterin
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additional information
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depurination shows strong salt sensitivity, mechanism of electrostatically facilitatetd ribosome targeting
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additional information
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no inhibition of cell toxicity by Gb4-liposomes, lactose, and sucrose
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