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Information on EC 3.1.3.26 - 4-phytase
for references in articles please use BRENDA:EC3.1.3.26
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EC Tree 3 Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.26 4-phytase
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
- 3.1.3.26
- phosphorus
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broiler
- meal
- aspergillus
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phytic
- wheat
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bird
- ash
- soybean
- phosphatases
- corn
- tibia
-
poultry
-
corn-soybean
-
starter
-
digesta
- xylanase
- bran
- cereal
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allotted
-
monogastric
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meal-based
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quadratic
- flour
-
barrows
-
manure
- ileum
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feedstuffs
-
p-deficient
- hexaphosphate
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antinutritional
- gizzard
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metabolizable
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indigestible
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grower
- synthesis
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excreta
- agriculture
-
housed
- uteroferrin
- biotechnology
-
chromic
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coli-derived
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wheat-based
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non-starch
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equivalency
- food industry
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cereal-based
-
insps
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antinutrient
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corn-based
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sourdough
- apase
-
carbohydrase
- nutrition
Synonyms
phytase, purple acid phosphatase, 6-phytase, histidine acid phosphatase, ronozyme, phytase b, phya2, multiple inositol polyphosphate phosphatase, phya1, minpp, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
(natto) phytase
4-phytase
6-phytase
AppA
AppA2 phytase
BIFPSEUDO_03792
Blon_0263
HAP phytase
histidine acid phosphatase
Minpp
MOK1 phytase
multiple inositol polyphosphate phosphatase
myo-inositol hexakisphosphate phosphohydrolase
myo-inositol(1,2,3,4,5,6)hexakisphosphate phosphohydrolase
myo-inositolhexakisphosphate phosphohydrolase
orf19.3727
PAP
PAP type I
PAPhys
PHO112
Phy
PhyA
PhyA2
PhyB
phytase
phytate 6-phosphatase
-
-
-
-
PJ3 phytase
purple acid phosphatase
r-PhyA170
r-PhyA86
additional information
6-phytase
-
-
-
-
AppA2 phytase
-
the enzyme may be a 3-phytase, EC 3.1.3.8, or a 6-phytase, EC 3.1.3.26. The product of the hydrolysis of myo-inositol hexakisphosphate i.e. myo-inositol 1,2,3,4,5-pentakisphosphate or myo-inositol 1,3,4,5,6-pentakisphosphate has not been identified
phytase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate
The product can also be designated as 1L-myo-inositol 1,2,3,4,5-pentakisphosphate when the 1L numbering is applied. Therfore the enzyme is frequently called 6-phytase.
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
phytate degradation I
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SYSTEMATIC NAME
IUBMB Comments
myo-inositol-hexakisphosphate 4-phosphohydrolase
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CAS REGISTRY NUMBER
COMMENTARY
9001-89-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-phosphoglycerate + H2O
glycerate + phosphate
-
Substrates: -
Products: -
Products: -
?
4-nitrophenylphosphate + H2O
4-nitrophenol + phosphate
-
Substrates: -
Products: -
Products: -
?
5'-ATP + H2O
?
-
Substrates: 250% of the activity with myo-inositol hexakisphosphate
Products: -
Products: -
?
AMP + phosphate
adenosine + phosphate
-
Substrates: 43.9% of the activity with myo-inositol hexakisphosphate
Products: -
Products: -
?
D-glucose 6-phosphate + H2O
glucose + phosphate
-
Substrates: reaction is nearly as efficient as on phytate
Products: -
Products: -
?
D-ribose 5-phosphate + H2O
D-ribose + phosphate
-
Substrates: 50% of the activity with myo-inositol hexakisphosphate
Products: -
Products: -
?
myo-inositol hexakisphosphate + H2O
1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate
myo-inositol hexakisphosphate + H2O
L-myo-inositol 1,2,3,4,5-pentakisphosphate + myo-inositol 1,2,3,4,6-pentakisphosphate + myo-inositol 1,3,4,5,6-pentakisphosphate + myo-inositol 2-phosphate + D-myo-inositol 1,2-bisphosphate + L-myo-inositol 1,2-bis phosphate + L-myo-inositol 1,2,3,4-tetrakisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
myo-inositol-1,2,3,4,5 pentakisphosphate + H2O
?
-
Substrates: 12% of the activity with myo-inositol 1,2,3,4,5,6-hexakisphosphate
Products: -
Products: -
?
myo-inositol-1,2,3,4,6 pentakisphosphate + H2O
?
-
Substrates: 22% of the activity with myo-inositol 1,2,3,4,5,6-hexakisphosphate
Products: -
Products: -
?
myo-inositol-1,2,4,5,6 pentakisphosphate + H2O
?
-
Substrates: 16% of the activity with myo-inositol 1,2,3,4,5,6-hexakisphosphate
Products: -
Products: -
?
myo-inositol-1,3,4,5,6 pentakisphosphate + H2O
?
-
Substrates: 27% of the activity with myo-inositol 1,2,3,4,5,6-hexakisphosphate
Products: -
Products: -
?
myo-inositol-5-phosphate + H2O
inositol + phosphate
-
Substrates: 18% of the activity with myo-inositol hexakisphosphate
Products: -
Products: -
?
phenyl phosphate
phenol + phosphate
-
Substrates: -
Products: -
Products: -
?
1-naphthyl phosphate + H2O
1-naphthol + phosphate
-
Substrates: 74% of the activity with myo-inositol hexakisphosphate
Products: -
Products: -
?
1-naphthyl phosphate + H2O
1-naphthol + phosphate
-
Substrates: 130% of the activity with myo-inositol hexakisphosphate
Products: -
Products: -
?
1-naphthyl phosphate + H2O
1-naphthol + phosphate
-
Substrates: -
Products: -
Products: -
?
1-naphthyl phosphate + H2O
1-naphthol + phosphate
-
Substrates: 89.6% of the activity with myo-inositol hexakisphosphate
Products: -
Products: -
?
1-naphthyl phosphate + H2O
1-naphthol + phosphate
-
Substrates: -
Products: -
Products: -
?
1-naphthyl phosphate + H2O
1-naphthol + phosphate
-
Substrates: -
Products: -
Products: -
?
2-naphthyl phosphate + H2O
2-naphthol + phosphate
-
Substrates: 63.6% of the activity with myo-inositol hexakisphosphate
Products: -
Products: -
?
2-naphthyl phosphate + H2O
2-naphthol + phosphate
-
Substrates: -
Products: -
Products: -
?
2-naphthyl phosphate + H2O
2-naphthol + phosphate
-
Substrates: 97.1% of the activity with myo-inositol hexakisphosphate
Products: -
Products: -
?
2-naphthyl phosphate + H2O
2-naphthol + phosphate
-
Substrates: -
Products: -
Products: -
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
Substrates: -
Products: -
Products: -
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
Substrates: -
Products: -
Products: -
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
Substrates: 39.8% of the activity with myo-inositol hexakisphosphate
Products: -
Products: -
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
Substrates: 11% of the activity with myo-inositol hexakisphosphate
Products: -
Products: -
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
Substrates: 11% of the activity with myo-inositol hexakisphosphate
Products: -
Products: -
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
Substrates: 101% of the activity with myo-inositol hexakisphosphate
Products: -
Products: -
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
Substrates: -
Products: -
Products: -
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
Substrates: -
Products: -
Products: -
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
Substrates: -
Products: -
Products: -
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
Substrates: The enzyme may be a 3-phytase, EC 3.1.3.8, or a 4-phytase (synonym 6-phytase, EC 3.1.3.26). The product of the hydrolysis of myo-inositol hexakisphosphate to 1D-myo-inositol 1,2,4,5,6-pentakisphosphate (3-phytase) or 1D-myo-inositol 1,2,3,5,6-pentakisphosphate (4-phytase) (i.e. 1L-myo-inositol 1,2,3,4,5-pentakisphosphate if 1L numbering is applied) has not been analyzed. The reaction was monitored by analyzing the released phosphate
Products: -
Products: -
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
Substrates: 59.6% of the activity with myo-inositol hexakisphosphate
Products: -
Products: -
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
Substrates: -
Products: -
Products: -
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
Substrates: reaction is nearly as efficient as on phytate
Products: -
Products: -
?
ADP + H2O
?
-
Substrates: 25.6% of the activity with myo-inositol hexakisphosphate
Products: -
Products: -
?