Literature summary for 3.1.3.26 extracted from

Tsang, P.W.; Fong, W.P.; Samaranayake, L.P.
Candida albicans orf19.3727 encodes phytase activity and is essential for human tissue damage (2017), PLoS ONE, 12, e0189219 .

Search for more literature for 3.1.3.26

Cloned(Commentary)

Cloned (Comment)	Organism
orf19.3727 or gene PHO112, DNA and amino acid sequence determination and analysis	Candida albicans

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of gene disruption null mutants of orf19.3727 of both chromosomal copies by PCR-based gene targeting method, PCR using gene-specific primers and plasmids pFA-ARG4 or pFA-HIS1. The ura3 auxotrophy in the null mutants was recovered by integrating plasmid CIp10 (carries URA3) into the RPS10 locus. Candida albicans orf19.3727 reintegrants are created by transforming full-length orf19.3727 into the null mutants. Phenotypes, overview	Candida albicans

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell surface	-	Candida albicans	9986	-

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	A0A1D8PS71	-	-
Candida albicans ATCC MYA-2876	A0A1D8PS71	-	-

Synonyms

Synonyms	Comment	Organism
orf19.3727	locus name	Candida albicans
PHO112	-	Candida albicans

General Information

General Information	Comment	Organism
malfunction	disruption of Candida albicans orf19.3727 leads to decreased phytase activity, reduced ability to form hyphae, attenuated in vitro adhesion, and reduced ability to penetrate human epithelium, which are the major virulence attributes of this yeast	Candida albicans
physiological function	the enzyme encoded by orf19.3727 of Candida albicans plays a key role in fungal pathogenesis, functional role of orf19.3727 in yeast-to-hyphal morphogenesis, adhesion, and in vitro virulence. Candida albicans orf19.3727 contributes to phytase activity and is crucial for hyphal growth, adhesion, and cellular invasion, and ultimately to its pathogenic potential	Candida albicans

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Release 2023.1 (January 2023)