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IUBMB CommentsAlso acts slowly with CTP. Catalyses template-independent extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. See also EC 2.7.7.6 DNA-directed RNA polymerase.
Synonyms
poly(a) polymerase, pap i, fam46c, gld-2, star-pap, fam46a, poly(a) polymerase i, pap ii, papd5, mtpap,
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adenosine triphosphate:ribonucleic acid adenylyltransferase
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AMP polynucleotidylexotransferase
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ATP-polynucleotide adenylyltransferase
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ATP:polynucleotidylexotransferase
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Cid1
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putative cytoplasmic PAP, in addition to having PAP activity, Cid1 possesses substantial poly(U) polymerase activity
Hs2
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contains two PAP-associated domains and two nucleotidyl transferase motifs
non-canonical poly(A) RNA polymerase PAPD7
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nuclear poly(A) polymerase 1
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nuclear speckle targeted PIPKIalpha regulated-poly(A) polymerase
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nucleotidyltransferase, polyadenylate
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PAPbeta
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testis-specific PAP
poly(A) hydrolase
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poly(A) RNA polymerase protein 1
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poly(A) synthetase
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polyadenylate nucleotidyltransferase
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polyadenylate synthetase
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polyadenylic acid polymerase
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polyadenylic polymerase
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poly[A] polymerase beta
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RNA adenylating enzyme
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RNA formation factors, PF1
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terminal riboadenylate transferase
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Cid14
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FAM46B
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FAM46C
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GLD-2
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GLD2
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GLD2
isoform, also called TENT2, TUTase2, TUT2 or PAPD4
GLD4
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GLD4
isoform, also called TENT4B, PAPD5, TUTase3, TUT3
MTPAP
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PAP
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PAP
PAP is a template-independent polymerase that belongs to the DNA polymerase beta family of enzymes
PAP I
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Pap1p
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PAPalpha
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isoform
PAPgamma
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PAPS1
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PAPS4
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poly(A) polymerase
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poly(A) polymerase
PAP II
poly(A) polymerase
Q7XJ91
PAP IV
poly(A) polymerase
Q7XJ92
PAP III
poly(A) polymerase gamma
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poly(A) polymerase gamma
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polyadenylate polymerase
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polyadenylate polymerase
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polyadenylate polymerase
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polyadenylate polymerase
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Star-PAP
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isoform
Tb927.3.3160
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Tb927.3.3160
Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927
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Tb927.7.3780
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Tb927.7.3780
Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927
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Tpap
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testis-specific PAP
Tpap
testis-specific poly(A) polymerase
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ATP + RNAn = diphosphate + RNAn+3'-A
ATP + RNAn = diphosphate + RNAn+3'-A
mechanism
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ATP + RNAn = diphosphate + RNAn+3'-A
mechanism
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ATP + RNAn = diphosphate + RNAn+3'-A
mechanism
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ATP + RNAn = diphosphate + RNAn+3'-A
mechanism
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ATP + RNAn = diphosphate + RNAn+3'-A
mechanism
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ATP + RNAn = diphosphate + RNAn+3'-A
mechanism
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ATP + RNAn = diphosphate + RNAn+3'-A
mechanism
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ATP + RNAn = diphosphate + RNAn+3'-A
mechanism
Coturnix sp.
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ATP + RNAn = diphosphate + RNAn+3'-A
also acts slowly with CTP, catalyses template-dependent extension of the 3'-end of a DNA strand by one nucleotide at a time, cannot initiate a chain de nove, the primer, depending on source of the enzyme, may be an RNA or DNA fragment, or oligo(a) bearing a 3'-OH terminal group, see also EC 2.7.7.6 DNA-directed RNA polymerase
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ATP + RNAn = diphosphate + RNAn+3'-A
binding of enzyme to nuclear poly(A) binding protein results in 80-fold increase in apparent affinity for RNA, mechanism
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ATP + RNAn = diphosphate + RNAn+3'-A
SN2-in-line-mechanism
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ATP + RNAn = diphosphate + RNAn+3'-A
Arabidopsis possesses 4 genes for PAP, these genes are expressed at the level of mRNA in tissue-specific ways, transcripts from the four genes are alternatively spliced so as to yield mRNAs encoding highly truncated polypeptides
ATP + RNAn = diphosphate + RNAn+3'-A
initial interaction between RNA and the enzyme is characterized by a high enthalpy of association. The minimal RNA binding site of the enzyme is eight nucleotides. Upon RNA binding, the enzyme undergoes structural modifications, although the interaction does not significantly modify the stability of the protein
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ATP + RNAn = diphosphate + RNAn+3'-A
non-uniform isomerization of the polymerase-primer complex with time consistent with a discontinuous (saltatory) translocation mechanism. Three distinct translocatory phases can be discerned: a -10(U)-binding site forward movement, a -27/-26(UU)-binding site jump to -10, then a -27/-26(UU)-binding site movement further downstream. Poly(A) tail elongation shows no apparent pauses during these isomerizations
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ATP:polynucleotide adenylyltransferase
Also acts slowly with CTP. Catalyses template-independent extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. See also EC 2.7.7.6 DNA-directed RNA polymerase.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(A)15 + n ATP
(A)15+n + n diphosphate
in the presence of ATP, the incorporation of several nucleotides into the RNA substrate is observed
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(A)n + ATP
(A)n+1 + diphosphate
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?
(A)n + CTP
(A)n-C + diphosphate
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?
(A)n + diphosphate
(A)n-1 + ATP
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?
(A)n + GTP
(A)n-G + diphosphate
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?
2-aminopurine riboside triphosphate + RNA
?
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adenosine 5'-O-(1-thiotriphosphate) + RNA
diphosphate + ?
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SP-diastereomer
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?
ATP + 3' untranslated region of mRNA
diphosphate + ?
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?
ATP + adenosine(5')diphospho(5')adenosine
diphosphate + ?
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i.e. AP2A
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?
ATP + adenosine(5')pentaphospho(5')adenosine
diphosphate + ?
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i.e. AP5A
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?
ATP + adenosine(5')tetraphospho(5')adenosine
diphosphate + ?
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i.e. AP4A
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?
ATP + adenosine(5')triphospho(5')adenosine
diphosphate + ?
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i.e. AP3A
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?
ATP + AMP
diphosphate + ?
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?
ATP + CMP
diphosphate + ?
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?
ATP + CTP
diphosphate + ?
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?
ATP + dGTP
diphosphate + ?
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?
ATP + GDP
diphosphate + ?
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?
ATP + GLUT1 mRNA poly(A) tail
?
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ATP + GTP
diphosphate + ?
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?
ATP + guanosine
diphosphate + ?
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?
ATP + guanosine(5')diphospho(5')guanosine
diphosphate + ?
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i.e. GP2G
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?
ATP + guanosine(5')pentaphospho(5')guanosine
diphosphate + ?
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i.e. GP5G
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?
ATP + guanosine(5')tetraphospho(5')guanosine
diphosphate + ?
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i.e. GP4G
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?
ATP + guanosine(5')triphospho(5')guanosine
diphosphate + ?
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i.e. GP3G
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?
ATP + IMP
diphosphate + ?
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?
ATP + miR-21-5p
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enzyme isoform PAPD5 adenylates the 3'-end of miR-21-5p, marking it for 3'-to-5'-trimming by the poly(A) specific ribonuclease PARN
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ATP + myosin short poly(A)
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ATP + nucleotide
?
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?
ATP + oligo(A)12
diphosphate + oligo(A)13
ATP + oligo(A)14
diphosphate + oligo(A)15
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?
ATP + oligo(A)15
diphosphate + oligo(A)16
ATP + oligo(A)17C
diphosphate + oligo(A)18C
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?
ATP + oligo(A)18
diphosphate + oligo(A)19
ATP + oligo(A)n
diphosphate + oligo(A)n+1
ATP + oligo(U)n
diphosphate + ?
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?
ATP + oligoadenylate
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?
ATP + poly(A)n
diphosphate + poly(A)n+1
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?
ATP + RNA
diphosphate + RNA(A)n
ATP + RNA (A)15
diphosphate + RNA (A)16
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?
ATP + RNA (A)15
diphosphate + RNA(A)16
ATP + RNA primer
?
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?
ATP + RNA primer
diphosphate + RNA primer-A
ATP + RNA(A)15
diphosphate + RNA(A)16
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?
ATP + RNAn
diphosphate + RNAn+1
ATP + rRNA
diphosphate + ?
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?
ATP + XTP
diphosphate + ?
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?
ATP + yeast tRNAiMet
diphosphate + ?
in vitro-synthesized yeast tRNAiMet, but not the native tRNA is substrate
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?
CTP + RNA
diphosphate + ?
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12% of the activity with ATP, adenylyltransferase A
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CTP + RNA primer
diphosphate + RNA primer-C
enzyme can use UTP, CTP and GTP as co-substrates in vitro
enzyme can use UTP, CTP and GTP as co-substrates in vitro
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?
CTP + RNAn
diphosphate + RNAn+1
dATP + RNA
diphosphate + ?
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15% of the activity with ATP
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GTP + RNA primer
diphosphate + RNA primer-G
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enzyme can use UTP, CTP and GTP as co-substrates in vitro
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mRNA of isoform gld-1 + ATP
polyadenylated mRNA of isoform gld-1 + diphosphate
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reaction catalyzed by enzyme isoform GLD-2
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UTP + RNA
diphosphate + RNA(U)n
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recombinant Cid1 shows a preference for UTP over ATP, the poly(U) polymerase activity of recombinant Cid1 out-competes its PAP activity under physiologically relevant conditions
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UTP + RNA primer
diphosphate + RNA primer-U
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enzyme can use UTP, CTP and GTP as co-substrates in vitro
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additional information
?
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ATP + oligo(A)12
diphosphate + oligo(A)13
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?
ATP + oligo(A)12
diphosphate + oligo(A)13
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?
ATP + oligo(A)15
diphosphate + oligo(A)16
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?
ATP + oligo(A)15
diphosphate + oligo(A)16
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?
ATP + oligo(A)18
diphosphate + oligo(A)19
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?
ATP + oligo(A)18
diphosphate + oligo(A)19
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?
ATP + oligo(A)n
diphosphate + oligo(A)n+1
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?
ATP + oligo(A)n
diphosphate + oligo(A)n+1
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?
ATP + RNA
?
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processing and activation of stored mRNAs after resumption of development
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?
ATP + RNA
?
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overview of biological function
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ATP + RNA
?
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involved in the 3'-end processing of mRNA
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ATP + RNA
?
Coturnix sp.
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overview of biological function
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ATP + RNA
?
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overview of biological function
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ATP + RNA
?
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overview of biological function
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2.7.7.19 polynucleotide adenylyltransferase
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