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Literature summary for 2.7.7.19 extracted from

  • Li, W.; Li, W.; Laishram, R.S.; Hoque, M.; Ji, Z.; Tian, B.; Anderson, R.A.
    Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases (2017), Nucleic Acids Res., 45, 8930-8942 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.19

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + RNAn Homo sapiens
-
 diphosphate + RNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNAn
-
 Homo sapiens diphosphate + RNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
PAPalpha isoform Homo sapiens
PAPgamma isoform Homo sapiens
poly(A) polymerase
-
 Homo sapiens
Star-PAP isoform Homo sapiens
TUT1
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism nuclear enzyme isoforms regulate transcript abundance genome-wide. Isoform Star-PAP-specific polyadenylation site usage regulates the expression of the eukaryotic translation initiation factor EIF4A1, the tumor suppressor gene PTEN and the long non-coding RNANEAT1. Isoform Star-PAP-mediated alternative polyadenylation of PTEN is essential for DNA damage-induced increase of PTEN protein levels Homo sapiens