EC Number   |
Natural Substrates |
|---|
   2.7.7.19 | 2-aminopurine riboside triphosphate + RNA |
- |
| 2.7.7.19 | ATP + miR-21-5p |
enzyme isoform PAPD5 adenylates the 3'-end of miR-21-5p, marking it for 3'-to-5'-trimming by the poly(A) specific ribonuclease PARN |
| 2.7.7.19 | ATP + RNA |
- |
| 2.7.7.19 | ATP + RNA |
overview of biological function |
| 2.7.7.19 | ATP + RNA |
synthetic and hydrolytic activities are functions of the same molecule, the level of adenine nucleotides regulates synthesis and degradation of poly(A), the hydrolytic reaction is responsible for poly(A) shortening or turnover, poly(A) itself is a storage form of adenine nucleotides |
| 2.7.7.19 | ATP + RNA |
processing and activation of stored mRNAs after resumption of development |
| 2.7.7.19 | ATP + RNA |
the enzymatic machinery that catalyzes formation of 3'-ends of polyadenylated mRNAs consists of two distinct factors: a poly(A) polymerase and a cleavage/specificity factor required for the correct cleavage at the poly(A) site of pre-mRNA |
| 2.7.7.19 | ATP + RNA |
2 enzymes participate in the polyadenylation of chromosomal RNA, by a coupled mechanism, the chromatin bound enzyme adds 120-130 adenosine nucleotides to chromosomal RNA, the nucleoplasmic enzyme completes the polyadenylation by adding 80-90 more AMP units to the polyadenylated end |
| 2.7.7.19 | ATP + RNA |
involved in the 3'-end processing of mRNA |
| 2.7.7.19 | ATP + RNAn |
- |
