Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNAn | Mus musculus | - |
diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q68ED3 | - |
- |
Mus musculus | Q91YI6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNAn | - |
Mus musculus | diphosphate + RNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GLD2 | isoform, also called TENT2, TUTase2, TUT2 or PAPD4 | Mus musculus |
GLD4 | isoform, also called TENT4B, PAPD5, TUTase3, TUT3 | Mus musculus |
poly(A) polymerase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | double isoform Gld2/Gld4 depletion results in a strong deficit in theta burst stimulation-long term potentiation and an enhancement of N-methyl-D-aspartate receptor-dependent long term depression. Gld4 depletion has negligible effects on hippocampal-dependent behaviors | Mus musculus |
malfunction | isoform Gld2 depletion from the mouse hippocampus results in a deficit in long term potentiation. Double isoform Gld2/Gld4 depletion results in a strong deficit in theta burst stimulation-long term potentiation and an enhancement of N-methyl-D-aspartate receptor-dependent long term depression. Gld2 depletion has negligible effects on hippocampal-dependent behaviors | Mus musculus |
physiological function | isoform Gld2 is essential for normal synaptic efficacy at least in the dentate gyrus of the hippocampus. Isoform Gld2 controls RNA processing, particularly exon skipping | Mus musculus |
physiological function | isoform Gld4 controls RNA processing, particularly exon skipping | Mus musculus |