Crystallization (Comment) | Organism |
---|---|
germ-line development defective GLD-2GLD-3 complex up-regulates the expression of genes required for meiotic progression. The structure of a minimal polyadenylation complex that includes the conserved nucleotidyl-transferase core of GLD-2 and the N-terminal domain of GLD-3, to 2.3 A resolution, shows that the N-terminal domain of GLD-3 does not fold into the predicted multi-K homology domain but wraps around the catalytic domain of GLD-2. GLD-3 activates GLD-2 both indirectly by stabilizing the enzyme and directly by contributing positively charged residues near the RNA-binding cleft. Due to distinct structural features, GLD-2 displays unusual specificity in vitro for single-stranded RNAs with at least one adenosine at the 3'-end | Caenorhabditis elegans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | O17087 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNA primer | isoform GLD-2 shows specificity in vitro for single-stranded RNAs with at least one adenosine at the 3'-end | Caenorhabditis elegans | diphosphate + RNA primer-A | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GLD-2 | - |
Caenorhabditis elegans |