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Literature summary for 2.7.7.19 extracted from

  • Yu, C.; Gong, Y.; Zhou, H.; Wang, M.; Kong, L.; Liu, J.; An, T.; Zhu, H.; Li, Y.
    Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model (2017), Cell Death Dis., 8, e2582 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the enzyme possesses tumor-suppressing activity and sensitizes breast cancer cells to chemotherapy drugs. In breast cancer patients, high levels of enzyme correlate with an improved prognosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + RNAn Homo sapiens
-
diphosphate + RNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H6E5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-
BT-20 cell
-
Homo sapiens
-
HCC-1937 cell
-
Homo sapiens
-
MCF-10A cell
-
Homo sapiens
-
MCF-12A cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-
MDA-MB-468 cell
-
Homo sapiens
-
SK-BR-3 cell
-
Homo sapiens
-
SUM-159PT cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNAn
-
Homo sapiens diphosphate + RNAn+1
-
?

Subunits

Subunits Comment Organism
? x * 90000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
poly(A) polymerase
-
Homo sapiens
Star-PAP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is downregulated in breast cancer down

General Information

General Information Comment Organism
physiological function ectopic enzyme expression inhibits proliferation as well as colony-forming ability of breast cancer cells. By regulating the expression of BCL2-interacting killer, the enzyme induces apoptosis of breast cancer cells through the mitochondrial pathway Homo sapiens