Application | Comment | Organism |
---|---|---|
medicine | the enzyme possesses tumor-suppressing activity and sensitizes breast cancer cells to chemotherapy drugs. In breast cancer patients, high levels of enzyme correlate with an improved prognosis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNAn | Homo sapiens | - |
diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9H6E5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
BT-20 cell | - |
Homo sapiens | - |
HCC-1937 cell | - |
Homo sapiens | - |
MCF-10A cell | - |
Homo sapiens | - |
MCF-12A cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
MDA-MB-468 cell | - |
Homo sapiens | - |
SK-BR-3 cell | - |
Homo sapiens | - |
SUM-159PT cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNAn | - |
Homo sapiens | diphosphate + RNAn+1 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 90000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
poly(A) polymerase | - |
Homo sapiens |
Star-PAP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is downregulated in breast cancer | down |
General Information | Comment | Organism |
---|---|---|
physiological function | ectopic enzyme expression inhibits proliferation as well as colony-forming ability of breast cancer cells. By regulating the expression of BCL2-interacting killer, the enzyme induces apoptosis of breast cancer cells through the mitochondrial pathway | Homo sapiens |