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Literature summary for 2.7.7.19 extracted from

  • Kuchta, K.; Muszewska, A.; Knizewski, L.; Steczkiewicz, K.; Wyrwicz, L.S.; Pawlowski, K.; Rychlewski, L.; Ginalski, K.
    FAM46 proteins are novel eukaryotic non-canonical poly(A) polymerases (2016), Nucleic Acids Res., 44, 3534-3548 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.19

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + RNAn Homo sapiens
-
 diphosphate + RNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5VWP2
-
-
Homo sapiens Q8NEK8
-
-
Homo sapiens Q96A09
-
-
Homo sapiens Q96IP4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNAn
-
 Homo sapiens diphosphate + RNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
FAM46A isoform Homo sapiens
FAM46B isoform Homo sapiens
FAM46C isoform Homo sapiens
FAM46D isoform Homo sapiens
PAP
-
 Homo sapiens
poly(A) polymerase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme regulates gene expression and probably plays a critical role during cell differentiation. Isoform FAM46C is a causal driver of multiple myeloma Homo sapiens
physiological function the enzyme regulates gene expression and probably plays a critical role during cell differentiation. The enzyme gene may be involved in the development of major malignancies including lung, colorectal, hepatocellular, head and neck, urothelial, endometrial and renal papillary carcinomas and melanoma Homo sapiens