Cloned (Comment) | Organism |
---|---|
expressed in HEK-293 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
D90A/D92A | catalytically inactive | Homo sapiens |
D90A/D92A | catalytically inactive | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Mus musculus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | 0.5 mM used in assay conditions | Homo sapiens | |
Mg2+ | 0.5 mM used in assay conditions | Mus musculus | |
Mn2+ | 0.5 mM used in assay conditions | Homo sapiens | |
Mn2+ | 0.5 mM used in assay conditions | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNAn | Homo sapiens | - |
diphosphate + RNAn+1 | - |
? | |
ATP + RNAn | Mus musculus | - |
diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q5VWP2 | - |
- |
Mus musculus | Q5SSF7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Mus musculus | - |
HL-60 cell | - |
Homo sapiens | - |
myeloma cell | - |
Homo sapiens | - |
NCI-H929 cell | - |
Homo sapiens | - |
RPMI-8226 cell | - |
Homo sapiens | - |
SK-MM-1 cell | - |
Homo sapiens | - |
splenocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + oligo(A)15 | - |
Homo sapiens | diphosphate + oligo(A)16 | - |
? | |
ATP + oligo(A)15 | - |
Mus musculus | diphosphate + oligo(A)16 | - |
? | |
ATP + RNAn | - |
Homo sapiens | diphosphate + RNAn+1 | - |
? | |
ATP + RNAn | - |
Mus musculus | diphosphate + RNAn+1 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * about 60000, His-Sumo-tagged enzyme, SDS-PAGE | Homo sapiens |
? | x * about 60000, His-Sumo-tagged enzyme, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
FAM46C | - |
Homo sapiens |
FAM46C | - |
Mus musculus |
PAP | - |
Homo sapiens |
PAP | - |
Mus musculus |
poly(A) polymerase | - |
Homo sapiens |
poly(A) polymerase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme knockout mice display reduced blood hemoglobin levels and activated primary B lymphocytes proliferate faster | Mus musculus |
physiological function | the enzyme acts as an onco-suppressor with the specificity for B-lymphocyte lineage from which multiple myeloma originates. The enzyme controls survival and proliferation of multiple myeloma cells | Homo sapiens |
physiological function | the enzyme is strongly induced during activation of primary splenocytes | Mus musculus |