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Literature summary for 2.7.7.19 extracted from

  • Mroczek, S.; Chlebowska, J.; Kulinski, T.M.; Gewartowska, O.; Gruchota, J.; Cysewski, D.; Liudkovska, V.; Borsuk, E.; Nowis, D.; Dziembowski, A.
    The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma (2017), Nat. Commun., 8, 619 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
D90A/D92A catalytically inactive Homo sapiens
D90A/D92A catalytically inactive Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
cytosol
-
Mus musculus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 0.5 mM used in assay conditions Homo sapiens
Mg2+ 0.5 mM used in assay conditions Mus musculus
Mn2+ 0.5 mM used in assay conditions Homo sapiens
Mn2+ 0.5 mM used in assay conditions Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + RNAn Homo sapiens
-
diphosphate + RNAn+1
-
?
ATP + RNAn Mus musculus
-
diphosphate + RNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5VWP2
-
-
Mus musculus Q5SSF7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
Mus musculus
-
HL-60 cell
-
Homo sapiens
-
myeloma cell
-
Homo sapiens
-
NCI-H929 cell
-
Homo sapiens
-
RPMI-8226 cell
-
Homo sapiens
-
SK-MM-1 cell
-
Homo sapiens
-
splenocyte
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + oligo(A)15
-
Homo sapiens diphosphate + oligo(A)16
-
?
ATP + oligo(A)15
-
Mus musculus diphosphate + oligo(A)16
-
?
ATP + RNAn
-
Homo sapiens diphosphate + RNAn+1
-
?
ATP + RNAn
-
Mus musculus diphosphate + RNAn+1
-
?

Subunits

Subunits Comment Organism
? x * about 60000, His-Sumo-tagged enzyme, SDS-PAGE Homo sapiens
? x * about 60000, His-Sumo-tagged enzyme, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
FAM46C
-
Homo sapiens
FAM46C
-
Mus musculus
PAP
-
Homo sapiens
PAP
-
Mus musculus
poly(A) polymerase
-
Homo sapiens
poly(A) polymerase
-
Mus musculus

General Information

General Information Comment Organism
malfunction enzyme knockout mice display reduced blood hemoglobin levels and activated primary B lymphocytes proliferate faster Mus musculus
physiological function the enzyme acts as an onco-suppressor with the specificity for B-lymphocyte lineage from which multiple myeloma originates. The enzyme controls survival and proliferation of multiple myeloma cells Homo sapiens
physiological function the enzyme is strongly induced during activation of primary splenocytes Mus musculus