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Literature summary for 2.7.7.19 extracted from

  • Kashiwabara, S.I.; Tsuruta, S.; Okada, K.; Yamaoka, Y.; Baba, T.
    Adenylation by testis-specific cytoplasmic poly(A) polymerase, PAPOLB/TPAP, is essential for spermatogenesis (2016), J. Reprod. Dev., 62, 607-614 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.19

Protein Variants

Protein Variants Comment Organism
D114A polyadenylation-defective mutant Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ 0.5 mM used in assay conditions Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + RNAn Mus musculus
-
 diphosphate + RNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9WVP6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spermatid
-
 Mus musculus
-
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + oligo(A)12
-
 Mus musculus diphosphate + oligo(A)13
-
 ?
ATP + RNAn
-
 Mus musculus diphosphate + RNAn+1
-
 ?

Subunits

Subunits Comment Organism
? x * 72000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
PAPOLB/TPAP
-
 Mus musculus
poly(A) polymerase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme deficiency leads to reduced expression of haploid-specific mRNAs, spermiogenesis arrest and male infertility Mus musculus
physiological function the enzyme is essential for spermatogenesis through its adenylation activitiy Mus musculus