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Literature summary for 2.7.7.19 extracted from

  • Newie, I.; Sokilde, R.; Persson, H.; Jacomasso, T.; Gorbatenko, A.; Borg, A.; de Hoon, M.; Pedersen, S.F.; Rovira, C.
    HER2-encoded mir-4728 forms a receptor-independent circuit with miR-21-5p through the non-canonical poly(A) polymerase PAPD5 (2016), Sci. Rep., 6, 35664 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + miR-21-5p Homo sapiens enzyme isoform PAPD5 adenylates the 3'-end of miR-21-5p, marking it for 3'-to-5'-trimming by the poly(A) specific ribonuclease PARN ?
-
 ?
ATP + RNAn Homo sapiens
-
 diphosphate + RNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NDF8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
BT-474 cell
-
 Homo sapiens
-
SK-BR-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + miR-21-5p enzyme isoform PAPD5 adenylates the 3'-end of miR-21-5p, marking it for 3'-to-5'-trimming by the poly(A) specific ribonuclease PARN Homo sapiens ?
-
 ?
ATP + RNAn
-
 Homo sapiens diphosphate + RNAn+1
-
 ?

Subunits

Subunits Comment Organism
? x * 63000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
PapD5
-
 Homo sapiens
poly(A) polymerase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the mature miRNA miR-4728-3p downregulates isoform PAPD5 down

General Information

General Information Comment Organism
metabolism the enzyme is involved in non-templated 3'-adenylation of miRNAs Homo sapiens