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Literature summary for 2.7.7.19 extracted from
- Deregulation of poly(A) polymerase I in Escherichia coli inhibits protein synthesis and leads to cell death (2013), Nucleic Acids Res., 41, 1757-1766.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P0ABF1 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PcnB | - |
Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | mature tRNAs, which are normally not substrates for PAP I in wild-type cells, are rapidly polyadenylated as PAP I levels increase upon overexpression, leading to dramatic reductions in the fraction of aminoacylated tRNAs, cessation of protein synthesis and cell death. The toxicity associated with PAP I is exacerbated by the absence of either RNase T and/or RNase PH. Regulation of PAP I is critical not for preventing the decay of mRNAs, but rather for maintaining normal levels of functional tRNAs and protein synthesis | Escherichia coli |
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