EC Number |
Activating Compound |
Reference |
---|
2.7.7.19 | 3',5'-AMP |
slight stimulation |
642956 |
2.7.7.19 | Dinucleotide |
in presence of 0.5 mM ATP, activation in decreasing order: GP4G, GP3G, AP6A, GP2G, AP4A, AP2A, GP5G, AP5A, AP3A, activation at 0.01 mM is 4-10fold |
642990 |
2.7.7.19 | dithiothreitol |
required |
642962 |
2.7.7.19 | germ cell-specific gene 1 protein |
TPAP interaction partner protein leading to redistribution of TPAP from the cytosol to the endoplasmic reticulum |
692341 |
2.7.7.19 | host factor I |
Hfq-PAP I interaction facilitates RNA recognition by PAP I |
661706 |
2.7.7.19 | KCl |
major poly(A) polymerase, optimal at 250 mM, minor poly(A) polymerase, optimal at 125 mM, inhibition of both above 250 mM |
642981 |
2.7.7.19 | more |
other phosphoinositides besides phosphatidylinositol 4,5-bisphosphate do not affect Star-PAP activity, and no phosphoinositide has an effect on PAPalpha activity |
694335 |
2.7.7.19 | more |
PAP phosphorylation of serine 537 by extracellular signal-regulated kinase increases its nonspecific polyadenylation activity |
694459 |
2.7.7.19 | more |
the enzyme is kept inactive in the G complex prior to the onset of meiotic maturation. Activation could involve the removal of inhibitory modifications of GLD2 |
663382 |
2.7.7.19 | phosphatidylinositol 4,5-bisphosphate |
in the presence of 50 mM phosphatidylinositol 4,5-bisphosphate Star-PAP activity is markedly stimulated |
694335 |