Reference on EC 2.7.10.1 - receptor protein-tyrosine kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dassa, J.; Marck, C.; Boquet, P.L.
The complete nucleotide sequence of the Escherichia coli gene appA reveals significant homology between pH 2.5 acid phosphatase and glucose-1-phosphatase
J. Bacteriol.
172
5497-5500
1990
Escherichia coli (P38134)
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
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365-370
2003
Rattus norvegicus (O08775), Homo sapiens (P00533), Homo sapiens (P04629), Homo sapiens (P06213), Homo sapiens (P07949), Homo sapiens (P17948), Homo sapiens (Q9UM73), Drosophila melanogaster (P04412), Caenorhabditis elegans (Q10656), Gallus gallus (Q91044), Gallus gallus (Q91987)
MacKintosh, C.; MacKintosh, R.W.
Inhibitors of protein kinases and phosphatases
Trends Biochem. Sci.
19
444-448
1994
eukaryota
Grangeasse, C.; Doublet, P.; Cozzone, A.J.
Tyrosine phosphorylation of protein kinase Wzc from Escherichia coli K12 occurs through a two-step process
J. Biol. Chem.
277
7127-7135
2002
Escherichia coli (P76387)
Perna, N.T.; Plunkett, G.; Burland, V.; Mau, B.; Glasner, J.D.; et al.
Genome sequence of enterohaemorrhagic Escherichia coli O157:H7
Nature
409
529-533
2001
Escherichia coli (Q8X7L9), Escherichia coli (Q8XC28)
Parkhill, J.; Dougan, G.; James, K.D.; Thomson, N.R.; Pickard, D.; Wain, J.; et al.
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
Nature
413
848-852
2001
Salmonella enterica subsp. enterica serovar Typhimurium (Q8Z5G6)
McClelland, M.; Sanderson, K.E.; Spieth, J.; Clifton, S.W.; Latreille, P.; et al.
Complete genome sequence of Salmonella enterica serovar typhimurium LT2
Nature
413
852-856
2001
Salmonella enterica subsp. enterica serovar Typhimurium (Q9F7B1)
Hayashi, T.; Makino, K.; Ohnishi, M.; Kurokawa, K.; Ishii, K.; et al.
Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12
DNA Res.
8
11-22
2001
Escherichia coli (Q8X7L9), Escherichia coli (Q8XC28), Escherichia coli O157 (Q8X7L9)
Vincent, C.; Duclos, B.; Grangeasse, C.; Vaganay, E.; Riberty, M.; Cozzone, A.J.; Doublet, P.
Relationship between exopolysaccharide production and protein-tyrosine phosphorylation in gram-negative bacteria
J. Mol. Biol.
304
311-321
2000
Escherichia coli (P38134), Escherichia coli (P76387)
Stevenson, G.; Lan, R.; Reeves, P.R.
The colanic acid gene cluster of Salmonella enterica has a complex history
FEMS Microbiol. Lett.
191
11-16
2000
Salmonella enterica subsp. enterica serovar Typhimurium (Q9F7B1)
Vincent, C.; Doublet, P.; Grangeasse, C.; Vaganay, E.; Cozzone, A.J.; Duclos, B.
Cells of Escherichia coli contain a protein-tyrosine kinase, Wzc, and a phosphotyrosine-protein phosphatase, Wzb
J. Bacteriol.
181
3472-3477
1999
Escherichia coli (P76387)
Ilan, O.; Bloch, Y.; Frankel, G.; Ullrich, H.; Geider, K.; Rosenshine, I.
Protein tyrosine kinases in bacterial pathogens are associated with virulence and production of exopolysaccharide
EMBO J.
18
3241-3248
1999
Escherichia coli (P58764), Escherichia coli
Doublet, P.; Vincent, C.; Grangeasse, C.; Cozzone, A.J.; Duclos, B.
On the binding of ATP to the autophosphorylating protein, Ptk, of the bacterium Acinetobacter johnsonii
FEBS Lett.
445
137-143
1999
Acinetobacter johnsonii (O52788), Acinetobacter johnsonii
Grangeasse, C.; Doublet, P.; Vaganay, E.; Vincent, C.; Deleage, G.; Duclos, B.; Cozzone, A.J.
Characterization of a bacterial gene encoding an autophosphorylating protein tyrosine kinase
Gene
204
259-265
1997
Acinetobacter johnsonii (O52788), Acinetobacter johnsonii
Blattner, F.R.; Plunkett, G.; Bloch, C.A.; Perna, N.T.; et al.
The complete genome sequence of Escherichia coli K-12
Science
277
1453-1474
1997
Escherichia coli (P38134), Escherichia coli (P76387)
Stevenson, G.; Andrianopoulos, K.; Hobbs, M.; Reeves, P.R.
Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid
J. Bacteriol.
178
4885-4893
1996
Escherichia coli (P76387)
Oshima, T.; Aiba, H.; Baba, T.; Fujita, K.; Hayashi, K.; Honjo, A.; et al.
A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map
DNA Res.
3
137-155
1996
Escherichia coli (P38134)
Itoh, T.; Aiba, H.; Baba, T.; Hayashi, K.; Inada, T.; Isono, K.; et al.
A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map
DNA Res.
3
379-392
1996
Escherichia coli (P76387)
Duclos, B.; Grangeasse, C.; Vaganay, E.; Riberty, M.; Cozzone, A.J.
Autophosphorylation of a bacterial protein at tyrosine
J. Mol. Biol.
259
891-895
1996
Acinetobacter johnsonii (O52788)
Borodovsky, M.; Rudd, K.E.; Koonin, E.V.
Intrinsic and extrinsic approaches for detecting genes in a bacterial genome
Nucleic Acids Res.
22
4756-4767
1994
Escherichia coli (P38134)
Pashmforoush, M.; Chan, S.J.; Steiner, D.F.
Structure and expression of the insulin-like peptide receptor from amphioxus
Mol. Endocrinol.
10
857-866
1996
Branchiostoma lanceolatum (O02466), Branchiostoma lanceolatum
Li, Y.Y.; McTiernan, C.F.; Feldman, A.M.
IL-1 beta alters the expression of the receptor tyrosine kinase gene r-EphA3 in neonatal rat cardiomyocytes
Am. J. Physiol.
274
H331-341
1998
Rattus norvegicus (O08680)
Park, S.; Sanchez, M.P.
The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands
Oncogene
14
533-542
1997
Mus musculus (O09127), Mus musculus
Bovenkamp, D.E.; Greer, P.
Novel Eph-family receptor tyrosine kinase is widely expressed in the developing zebrafish nervous system
Dev. Dyn.
209
166-181
1997
Danio rerio (O13146), Danio rerio
Araujo, M.; Nieto, M.A.
The expression of chick EphA7 during segmentation of the central and peripheral nervous system
Mech. Dev.
68
173-177
1997
Gallus gallus (O42422)
George, S.E.; Simokat, K.; Hardin, J.; Chisholm, A.D.
The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans
Cell
92
633-643
1998
Caenorhabditis elegans (O61460), Caenorhabditis elegans
Lyons, M.S.; Bell, B.; Stainier, D.; Peters, K.G.
Isolation of the zebrafish homologues for the tie-1 and tie-2 endothelium-specific receptor tyrosine kinases
Dev. Dyn.
212
133-140
1998
Danio rerio (O73791), Danio rerio
Ma, Y.; Longley, B.J.; Wang, X.; Blount, J.L.; Langley, K.; Caughey, G.H.
Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms
J. Invest. Dermatol.
112
165-170
1999
Canis lupus familiaris (O97799), Canis lupus familiaris
Nilsen, T.W.; Maroney, P.A.; Goodwin, R.G.; Rottman, F.M.; Crittenden, L.B.; Raines, M.A.; Kung, H.J.
C-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor
Cell
41
719-726
1985
Avian leukosis virus (P00534)
Debuire, B.; Henry, C.; Bernissa, M.; Biserte, G.; Claverie, J.M.; Saule, S.; Martin, P.; Stehelin, D.
Sequencing the erbA gene of avian erythroblastosis virus reveals a new type of oncogene
Science
224
1456-1459
1984
Avian erythroblastosis virus (P00535), Avian erythroblastosis virus, Avian erythroblastosis virus ES4 (P00535)
Yamamoto, T.; Nishida, T.; Miyajima, N.; Kawai, S.; Ooi, T.; Toyoshima, K.
The erbB gene of avian erythroblastosis virus is a member of the src gene family
Cell
35
71-78
1983
Avian erythroblastosis virus (P00535), Avian erythroblastosis virus ES4 (P00535)
Besmer, P.; Murphy, J.E.; George, P.C.; Qiu, F.H.; Bergold, P.J.; Lederman, L.; Snyder, H.W., Jr.; Brodeur, D.; Zuckerman, E.E.; Hardy, W.D.
A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family
Nature
320
415-421
1986
Feline sarcoma virus (P04048), Feline sarcoma virus, Feline sarcoma virus Hardy-Zuckerman 4 (P04048)
Coussens, L.; Yang-Feng, T.L.; Liao, Y.C.; Chen, E.; Gray, A.; McGrath, J.; Seeburg, P.H.; Libermann, T.A.; Schlessinger, J.; Francke, U.; et al.
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene
Science
230
1132-1139
1985
Homo sapiens (P04626), Homo sapiens
Ehsani, A.; Low, J.; Wallace, R.B.; Wu, A.M.
Characterization of a new allele of the human ERBB2 gene by allele-specific competition hybridization
Genomics
15
426-429
1993
Homo sapiens (P04626), Homo sapiens
Semba, K.; Kamata, N.; Toyoshima, K.; Yamamoto, T.
A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma
Proc. Natl. Acad. Sci. USA
82
6497-6501
1985
Homo sapiens (P04626), Homo sapiens
Yamamoto, T.; Ikawa, S.; Akiyama, T.; Semba, K.; Nomura, N.; Miyajima, N.; Saito, T.; Toyoshima, K.
Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor
Nature
319
230-234
1986
Homo sapiens (P04626), Homo sapiens
Nocka, K.; Buck, J.; Levi, E.; Besmer, P.
Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors
EMBO J.
9
3287-3294
1990
Mus musculus (P05532), Mus musculus
Nocka, K.; Tan, J.C.; Chiu, E.; Chu, T.Y.; Ray, P.; Traktman, P.; Besmer, P.
Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W
EMBO J.
9
1805-1813
1990
Mus musculus (P05532), Mus musculus
Qiu, F.H.; Ray, P.; Brown, K.; Barker, P.E.; Jhanwar, S.; Ruddle, F.H.; Besmer, P.
Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family--oncogenic activation of v-kit involves deletion of extracellular domain and C terminus
EMBO J.
7
1003-1011
1988
Mus musculus (P05532), Mus musculus
Rossi, P.; Marziali, G.; Albanesi, C.; Charlesworth, A.; Geremia, R.; Sorrentino, V.
A novel c-kit transcript, potentially encoding a truncated receptor, originates within a kit gene intron in mouse spermatids
Dev. Biol.
152
203-207
1992
Mus musculus (P05532), Mus musculus
Tan, J.C.; Nocka, K.; Ray, P.; Traktman, P.; Besmer, P.
The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase
Science
247
209-212
1990
Mus musculus (P05532), Mus musculus
Yarden, Y.; Escobedo, J.A.; Kuang, W.J.; Yang-Feng, T.L.; Daniel, T.O.; Tremble, P.M.; Chen, E.Y.; Ando, M.E.; Harkins, R.N.; Francke, U.; et al.
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors
Nature
323
226-232
1986
Mus musculus (P05622), Mus musculus
Koegl, M.; Zlatkine, P.; Ley, S.C.; Courtneidge, S.A.; Magee, A.I.
Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif
Biochem. J.
303
749-753
1994
Homo sapiens (P36888)
Shenoy-Scaria, A.M.; Gauen, L.K.; Kwong, J.; Shaw, A.S.; Lublin, D.M.
Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins
Mol. Cell. Biol.
13
6385-6392
1993
Homo sapiens (P36888)
Bargmann, C.I.; Hung, M.C.; Weinberg, R.A.
The neu oncogene encodes an epidermal growth factor receptor-related protein
Nature
319
226-230
1986
Rattus norvegicus (P06494)
Gullick, W.J.; Bottomley, A.C.; Lofts, F.J.; Doak, D.G.; Mulvey, D.; Newman, R.; Crumpton, M.J.; Sternberg, M.J.; Campbell, I.D.
Three dimensional structure of the transmembrane region of the proto-oncogenic and oncogenic forms of the neu protein
EMBO J.
11
43-48
1992
Rattus norvegicus (P06494)
Lai, C.; Lemke, G.
An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system
Neuron
6
691-704
1991
Rattus norvegicus (P06494), Rattus norvegicus (Q62956)
Andre, C.; Hampe, A.; Lachaume, P.; Martin, E.; Wang, X.P.; Manus, V.; Hu, W.X.; Galibert, F.
Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes
Genomics
39
216-226
1997
Homo sapiens (P07333), Homo sapiens (P10721)
Coussens, L.; Van Beveren, C.; Smith, D.; Chen, E.; Mitchell, R.L.; Isacke, C.M.; Verma, I.M.; Ullrich, A.
Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus
Nature
320
277-280
1986
Homo sapiens (P07333), Homo sapiens
Hampe, A.; Shamoon, B.M.; Gobet, M.; Sherr, C.J.; Galibert, F.
Nucleotide sequence and structural organization of the human FMS proto-oncogene
Oncogene Res.
4
9-17
1989
Homo sapiens (P07333), Homo sapiens
Visvader, J.; Verma, I.M.
Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes
Mol. Cell. Biol.
9
1336-1341
1989
Homo sapiens (P07333), Homo sapiens
Wheeler, E.F.; Roussel, M.F.; Hampe, A.; Walker, M.H.; Fried, V.A.; Look, A.T.; Rettenmier, C.W.; Sherr, C.J.
The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences
J. Virol.
59
224-233
1986
Homo sapiens (P07333), Homo sapiens
Abbott, A.M.; Bueno, R.; Pedrini, M.T.; Murray, J.M.; Smith, R.J.
Insulin-like growth factor I receptor gene structure
J. Biol. Chem.
267
10759-10763
1992
Homo sapiens (P08069), Homo sapiens
Cooke, D.W.; Bankert, L.A.; Roberts, C.T., Jr.; LeRoith, D.; Casella, S.J.
Analysis of the human type I insulin-like growth factor receptor promoter region
Biochem. Biophys. Res. Commun.
177
1113-1120
1991
Homo sapiens (P08069), Homo sapiens
Lee, S.T.; Strunk, K.M.; Spritz, R.A.
A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes
Oncogene
8
3403-3410
1993
Homo sapiens (P08069), Homo sapiens (P08581), Homo sapiens (P30530), Homo sapiens
Ullrich, A.; Gray, A.; Tam, A.W.; Yang-Feng, T.; Tsubokawa, M.; Collins, C.; Henzel, W.; Le Bon, T.; Kathuria, S.; Chen, E.; et al.
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity
EMBO J.
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1986
Homo sapiens (P08069), Homo sapiens
Bottaro, D.P.; Rubin, J.S.; Faletto, D.L.; Chan, A.M.; Kmiecik, T.E.; Vande Woude, G.F.; Aaronson, S.A.
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
Science
251
802-804
1991
Homo sapiens (P08581)
Chan, A.M.; King, H.W.; Tempest, P.R.; Deakin, E.A.; Cooper, C.S.; Brookes, P.
Primary structure of the met protein tyrosine kinase domain
Oncogene
1
229-233
1987
Homo sapiens (P08581), Homo sapiens
Dean, M.; Park, M.; Le Beau, M.M.; Robins, T.S.; Diaz, M.O.; Rowley, J.D.; Blair, D.G.; Vande Woude, G.F.
The human met oncogene is related to the tyrosine kinase oncogenes
Nature
318
385-388
1985
Homo sapiens (P08581), Homo sapiens
Ferracini, R.; Longati, P.; Naldini, L.; Vigna, E.; Comoglio, P.M.
Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase
J. Biol. Chem.
266
19558-19564
1991
Homo sapiens (P08581)
Park, M.; Dean, M.; Kaul, K.; Braun, M.J.; Gonda, M.A.; Vande Woude, G.
Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors
Proc. Natl. Acad. Sci. USA
84
6379-6383
1987
Homo sapiens (P08581), Homo sapiens
Schmidt, L.; Duh, F.M.; Chen, F.; Kishida, T.; Glenn, G.; Choyke, P.; Scherer, S.W.; Zhuang, Z.; Lubensky, I.; Dean, M.; Allikmets, R.; Chidambaram, A.; Bergerheim, U.R.; Feltis, J.T.; Casadevall, C.; Zamarron, A.; Bernues, M.; Richard, S.; Lips, C.J.; Walther, M.M.; Tsui, L.C.; Geil, L.; Orcutt, M.L.; Stackhouse, T.; Zbar, B.; et al.
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
Nat. Genet.
16
68-73
1997
Homo sapiens (P08581), Homo sapiens
Adams, M.D.; Celniker, S.E.; Holt, R.A.; Evans, C.A.; Gocayne, J.D.; et al.
The genome sequence of Drosophila melanogaster
Science
287
2185-2195
2000
Drosophila melanogaster (P13368), Drosophila melanogaster (Q07407), Drosophila melanogaster (Q24488), Drosophila melanogaster (Q27324), Drosophila melanogaster (Q9v422), Drosophila melanogaster (Q9v6k3), Drosophila melanogaster (Q9vie4)
Deloukas, P.; Matthews, L.H.; Ashurst, J.; Burton, J.; Gilbert, J.G.; et al.
The DNA sequence and comparative analysis of human chromosome 20
Nature
414
865-871
2001
Homo sapiens (P11362), Homo sapiens (Q12866)
Birchmeier, C.; Birnbaum, D.; Waitches, G.; Fasano, O.; Wigler, M.
Characterization of an activated human ros gene
Mol. Cell. Biol.
6
3109-3116
1986
Homo sapiens (P08922)
Birchmeier, C.; O'Neill, K.; Riggs, M.; Wigler, M.
Characterization of ROS1 cDNA from a human glioblastoma cell line
Proc. Natl. Acad. Sci. USA
87
4799-4803
1990
Homo sapiens (P08922)
Matsushime, H.; Wang, L.H.; Shibuya, M.
Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule
Mol. Cell. Biol.
6
3000-3004
1986
Homo sapiens (P08922), Homo sapiens
Ben-Neriah, Y.; Bauskin, A.R.
Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain
Nature
333
672-676
1988
Mus musculus (P08923), Mus musculus
Bernards, A.; de la Monte, S.M.
The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator
EMBO J.
9
2279-2287
1990
Mus musculus (P08923), Mus musculus
Haase, V.H.; Snijders, A.J.; Cooke, S.M.; Teng, M.N.; Kaul, D.; Le Beau, M.M.; Bruns, G.A.; Bernards, A.
Alternatively spliced ltk mRNA in neurons predicts a receptor with a larger putative extracellular domain
Oncogene
6
2319-2325
1991
Mus musculus (P08923)
Snijders, A.J.; Haase, V.H.; Bernards, A.
Four tissue-specific mouse ltk mRNAs predict tyrosine kinases that differ upstream of their transmembrane segment
Oncogene
8
27-35
1993
Mus musculus (P08923)
Snijders, A.J.; Ho, S.C.; Haase, V.H.; Pillai, S.; Bernards, A.
A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin
J. Biol. Chem.
272
1297-1301
1997
Mus musculus (P08923), Mus musculus
Fernandez, R.; Tabarini, D.; Azpiazu, N.; Frasch, M.; Schlessinger, J.
The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential
EMBO J.
14
3373-3384
1995
Drosophila melanogaster (P09208)
Nishida, Y.; Hata, M.; Nishizuka, Y.; Rutter, W.J.; Ebina, Y.
Cloning of a Drosophila cDNA encoding a polypeptide similar to the human insulin receptor precursor
Biochem. Biophys. Res. Commun.
141
474-481
1986
Drosophila melanogaster (P09208)
Petruzzelli, L.; Herrera, R.; Arenas-Garcia, R.; Fernandez, R.; Birnbaum, M.J.; Rosen, O.M.
Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody
Proc. Natl. Acad. Sci. USA
83
4710-4714
1986
Drosophila melanogaster (P09208)
Ruan, Y.; Chen, C.; Cao, Y.; Garofalo, R.S.
The Drosophila insulin receptor contains a novel carboxyl-terminal extension likely to play an important role in signal transduction
J. Biol. Chem.
270
4236-4243
1995
Drosophila melanogaster (P09208)
De Parseval, N.; Bordereaux, D.; Gisselbrecht, S.; Sola, B.
Reassessment of the murine c-fms proto-oncogene sequence
Nucleic Acids Res.
21
750
1993
Mus musculus (P09581), Mus musculus
Rothwell, V.M.; Rohrschneider, L.R.
Murine c-fms cDNA: cloning, sequence analysis and retroviral expression
Oncogene Res.
1
311-324
1987
Mus musculus (P09581), Mus musculus
Van der Geer, P.; Hunter, T.
Identification of tyrosine 706 in the kinase insert as the major colony-stimulating factor 1 (CSF-1)-stimulated autophosphorylation site in the CSF-1 receptor in a murine macrophage cell line
Mol. Cell. Biol.
10
2991-3002
1990
Mus musculus (P09581), Mus musculus
Yue, X.; Favot, P.; Dunn, T.L.; Cassady, A.I.; Hume, D.A.
Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation
Mol. Cell. Biol.
13
3191-3201
1993
Mus musculus (P09581), Mus musculus
Chi, K.D.; McPhee, R.A.; Wagner, A.S.; Dietz, J.J.; Pantazis, P.; Goustin, A.S.
Integration of proviral DNA into the PDGF beta-receptor gene in HTLV-I-infected T-cells results in a novel tyrosine kinase product with transforming activity
Oncogene
15
1051-1057
1997
Homo sapiens (P09619), Homo sapiens
Claesson-Welsh, L.; Eriksson, A.; Moren, A.; Severinsson, L.; Ek, B.; Ostman, A.; Betsholtz, C.; Heldin, C.H.
cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules
Mol. Cell. Biol.
8
3476-3486
1988
Homo sapiens (P09619), Homo sapiens
Gronwald, R.G.; Grant, F.J.; Haldeman, B.A.; Hart, C.E.; O'Hara, P.J.; Hagen, F.S.; Ross, R.; Bowen-Pope, D.F.; Murray, M.J.
Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class
Proc. Natl. Acad. Sci. USA
85
3435-3439
1988
Homo sapiens (P09619), Homo sapiens
Kazlauskas, A.; Cooper, J.A.
Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins
Cell
58
1121-1133
1989
Homo sapiens (P09619), Homo sapiens
Roberts, W.M.; Look, A.T.; Roussel, M.F.; Sherr, C.J.
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Drosophila melanogaster (P13368), Drosophila melanogaster
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Homo sapiens (P14616), Homo sapiens, Cavia porcellus (P14617), Cavia porcellus
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The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain
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Mus musculus (P16092), Mus musculus
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Mus musculus (P16092), Mus musculus
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Mus musculus (P16092), Mus musculus
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cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor
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Homo sapiens (P16234), Homo sapiens
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Homo sapiens (P16234), Homo sapiens
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Homo sapiens (P16234), Homo sapiens
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The Drosophila gene torso encodes a putative receptor tyrosine kinase
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Rattus norvegicus (P20786)
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Rattus norvegicus (P20786)
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Drosophila virilis (P20806), Drosophila virilis
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Homo sapiens (P21709), Homo sapiens
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Homo sapiens (P21802), Homo sapiens
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Homo sapiens (P21802)
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Homo sapiens (P21802), Homo sapiens
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Homo sapiens (P21802), Homo sapiens
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Homo sapiens (P21802)
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Homo sapiens (P21802)
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Homo sapiens (P21802), Homo sapiens
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Homo sapiens (P21802), Homo sapiens
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Homo sapiens (P21802), Homo sapiens
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Homo sapiens (P21802), Homo sapiens
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Homo sapiens (P21802), Homo sapiens
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Two cDNAs encoding novel human FGF receptor
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Homo sapiens (P21802), Homo sapiens
Steinberger, D.; Collmann, H.; Schmalenberger, B.; Muller, U.
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Homo sapiens (P21802), Homo sapiens
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Homo sapiens (P21802)
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Homo sapiens (P21802), Homo sapiens
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Homo sapiens (P21802)
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Homo sapiens (P21802), Homo sapiens
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Homo sapiens (P21802), Homo sapiens
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Mus musculus (P21803), Mus musculus
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Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin
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Mus musculus (P21803), Mus musculus
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Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop
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Mus musculus (P21803)
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Homo sapiens (P29317), Homo sapiens
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Homo sapiens (P29320), Homo sapiens
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Homo sapiens (P29320), Homo sapiens
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Homo sapiens (P29322), Homo sapiens (P29323), Homo sapiens
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Homo sapiens (P29323), Homo sapiens (P54756), Homo sapiens (P54764), Homo sapiens (Q15375)
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Homo sapiens (P29323), Homo sapiens
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Homo sapiens (P29323), Homo sapiens
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Homo sapiens (P29323), Homo sapiens
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Homo sapiens (P29376), Homo sapiens
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Homo sapiens (P29376), Homo sapiens
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Homo sapiens (P29376), Homo sapiens
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Homo sapiens (P30530), Homo sapiens
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Homo sapiens (P30530), Homo sapiens
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Caenorhabditis elegans (P34891), Caenorhabditis elegans (P34892)
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Homo sapiens (P34925), Homo sapiens
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The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain
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Homo sapiens (P34925), Homo sapiens
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Homo sapiens (P34925), Homo sapiens
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cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily
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Mus musculus (P35546), Mus musculus
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Homo sapiens (P35590), Homo sapiens
Barker, P.A.; Lomen-Hoerth, C.; Gensch, E.M.; Meakin, S.O.; Glass, D.J.; Shooter, E.M.
Tissue-specific alternative splicing generates two isoforms of the trkA receptor
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Rattus norvegicus (P35739)
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The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor
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Rattus norvegicus (P35739)
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FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter
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Homo sapiens (P35916), Homo sapiens
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The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor
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Homo sapiens (P35916), Homo sapiens
Pajusola, K.; Aprelikova, O.; Korhonen, J.; Kaipainen, A.; Pertovaara, L.; Alitalo, R.; Alitalo, K.
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Homo sapiens (P35916), Homo sapiens
Finnerty, H.; Kelleher, K.; Morris, G.E.; Bean, K.; Merberg, D.M.; Kriz, R.; Morris, J.C.; Sookdeo, H.; Turner, K.J.; Wood, C.R.
Molecular cloning of murine FLT and FLT4
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Mus musculus (P35917), Mus musculus, Homo sapiens (P35968)
Matthews, W.; Jordan, C.T.; Gavin, M.; Jenkins, N.A.; Copeland, N.G.; Lemischka, I.R.
A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit
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Mus musculus (P35918), Mus musculus
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High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
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Mus musculus (P35918), Mus musculus
Oelrichs, R.B.; Reid, H.H.; Bernard, O.; Ziemiecki, A.; Wilks, A.F.
NYK/FLK-1: a putative receptor protein tyrosine kinase isolated from E10 embryonic neuroepithelium is expressed in endothelial cells of the developing embryo
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Mus musculus (P35918), Mus musculus
Patterson, C.; Perrella, M.A.; Hsieh, C.M.; Yoshizumi, M.; Lee, M.E.; Haber, E.
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Mus musculus (P35918), Homo sapiens (P35968), Homo sapiens
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Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium
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Mus musculus (P35918), Mus musculus
Terman, B.I.; Carrion, M.E.; Kovacs, E.; Rasmussen, B.A.; Eddy, R.L.; Shows, T.B.
Identification of a new endothelial cell growth factor receptor tyrosine kinase
Oncogene
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Homo sapiens (P35968), Homo sapiens
Terman, B.I.; Dougher-Vermazen, M.; Carrion, M.E.; Dimitrov, D.; Armellino, D.C.; Gospodarowicz, D.; Bohlen, P.
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Homo sapiens (P35968)
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Isolation of a gene encoding a novel receptor tyrosine kinase from differentiated embryonic stem cells
Oncogene
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Homo sapiens (P35968), Homo sapiens
Kondo, K.; Hiratsuka, S.; Subbalakshmi, E.; Matsushime, H.; Shibuya, M.
Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors
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Mus musculus (P35969), Mus musculus
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Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene
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Homo sapiens (P36888), Homo sapiens
Rosnet, O.; Schiff, C.; Pebusque, M.J.; Marchetto, S.; Tonnelle, C.; Toiron, Y.; Birg, F.; Birnbaum, D.
Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells
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Homo sapiens (P36888), Homo sapiens
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STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells
Proc. Natl. Acad. Sci. USA
91
459-463
1994
Homo sapiens (P36888), Homo sapiens
Cooke, M.P.; Perlmutter, R.M.
Expression of a novel form of the fyn proto-oncogene in hematopoietic cells
New Biol.
1
66-74
1989
Homo sapiens (P36888)
Seykora, J.T.; Mei, L.; Dotto, G.P.; Stein, P.L.
Srcasm: a novel Src activating and signaling molecule
J. Biol. Chem.
277
2812-2822
2002
Homo sapiens (P36888)
Timson Gauen, L.K.; Linder, M.E.; Shaw, A.S.
Multiple features of the p59fyn src homology 4 domain define a motif for immune-receptor tyrosine-based activation motif (ITAM) binding and for plasma membrane localization
J. Cell Biol.
133
1007-1015
1996
Homo sapiens (P36888)
Wolven, A.; Okamura, H.; Rosenblatt, Y.; Resh, M.D.
Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association
Mol. Biol. Cell
8
1159-1173
1997
Homo sapiens (P36888)
Gilardi-Hebenstreit, P.; Nieto, M.A.; Frain, M.; Mattei, M.G.; Chestier, A.; Wilkinson, D.G.; Charnay, P.
An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain
Oncogene
7
2499-2506
1992
Mus musculus (Q03137), Mus musculus (Q03142), Mus musculus (Q03146), Mus musculus
Schacke, H.; Schroder, H.C.; Gamulin, V.; Rinkevich, B.; Muller, I.M.; Muller, W.E.
Molecular cloning of a tyrosine kinase gene from the marine sponge Geodia cydonium: a new member belonging to the receptor tyrosine kinase class II family
Mol. Membr. Biol.
11
101-107
1994
Geodia cydonium (P42159), Geodia cydonium
Kubota, T.; Hikono, H.; Sasaki, E.; Sakurai, M.
Sequence of a bovine c-kit proto-oncogene cDNA
Gene
141
305-306
1994
Bos taurus (P43481), Bos taurus
Eichmann, A.; Marcelle, C.; Breant, C.; Le Douarin, N.M.
Molecular cloning of Quek 1 and 2, two quail vascular endothelial growth factor (VEGF) receptor-like molecules
Gene
174
3-8
1996
Coturnix japonica (P52583)
Eichmann, A.; Marcelle, C.; Breant, C.; Le Douarin, N.M.
Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development
Mech. Dev.
42
33-48
1993
Coturnix japonica (P52583)
Flamme, I.; Breier, G.; Risau, W.
Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (flk-1) are expressed during vasculogenesis and vascular differentiation in the quail embryo
Dev. Biol.
169
699-712
1995
Coturnix japonica (P52583)
Yamane, A.; Seetharam, L.; Yamaguchi, S.; Gotoh, N.; Takahashi, T.; Neufeld, G.; Shibuya, M.
A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR/Flk-1)
Oncogene
9
2683-2690
1994
Rattus norvegicus (P53767)
Bohme, B.; Holtrich, U.; Wolf, G.; Luzius, H.; Grzeschik, K.H.; Strebhardt, K.; Rubsamen-Waigmann, H.
PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2
Oncogene
8
2857-2862
1993
Homo sapiens (P54753), Homo sapiens
Becker, N.; Seitanidou, T.; Murphy, P.; Mattei, M.G.; Topilko, P.; Nieto, M.A.; Wilkinson, D.G.; Charnay, P.; Gilardi-Hebenstreit, P.
Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain
Mech. Dev.
47
3-17
1994
Mus musculus (P54754), Mus musculus (Q03145), Mus musculus
Ciossek, T.; Lerch, M.M.; Ullrich, A.
Cloning, characterization, and differential expression of MDK2 and MDK5, two novel receptor tyrosine kinases of the eck/eph family
Oncogene
11
2085-2095
1995
Mus musculus (P54754), Mus musculus (P54761), Mus musculus
Imondi, R.; Wideman, C.; Kaprielian, Z.
Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons
Development
127
1397-1410
2000
Mus musculus (P54754)
Siever, D.A.; Verderame, M.F.
Identification of a complete Cek7 receptor protein tyrosine kinase coding sequence and cDNAs of alternatively spliced transcripts
Gene
148
219-226
1994
Gallus gallus (P54755), Gallus gallus
Maisonpierre, P.C.; Barrezueta, N.X.; Yancopoulos, G.D.
Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression
Oncogene
8
3277-3288
1993
Rattus norvegicus (P54757)
Taylor, V.; Miescher, G.C.; Pfarr, S.; Honegger, P.; Breitschopf, H.; Lassmann, H.; Steck, A.J.
Expression and developmental regulation of Ehk-1, a neuronal Elk-like receptor tyrosine kinase in brain
Neuroscience
63
163-178
1994
Rattus norvegicus (P54757)
Valenzuela, D.M.; Rojas, E.; Griffiths, J.A.; Compton, D.L.; Gisser, M.; Ip, N.Y.; Goldfarb, M.; Yancopoulos, G.D.
Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family
Oncogene
10
1573-1580
1995
Rattus norvegicus (P54759)
Bennett, B.D.; Wang, Z.; Kuang, W.J.; Wang, A.; Groopman, J.E.; Goeddel, D.V.; Scadden, D.T.
Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily
J. Biol. Chem.
269
14211-14218
1994
Homo sapiens (P54760), Homo sapiens
Wilson, M.D.; Riemer, C.; Martindale, D.W.; Schnupf, P.; Boright, A.P.; Cheung, T.L.; Hardy, D.M.; Schwartz, S.; Scherer, S.W.; Tsui, L.C.; Miller, W.; Koop, B.F.
Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5
Nucleic Acids Res.
29
1352-1365
2001
Homo sapiens (P54760)
Andres, A.C.; Reid, H.H.; Zurcher, G.; Blaschke, R.J.; Albrecht, D.; Ziemiecki, A.
Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis
Oncogene
9
1461-1467
1994
Mus musculus (P54761)
Stein, E.; Cerretti, D.P.; Daniel, T.O.
Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells
J. Biol. Chem.
271
23588-23593
1996
Homo sapiens (P54762), Homo sapiens
Tang, X.X.; Biegel, J.A.; Nycum, L.M.; Yoshioka, A.; Brodeur, G.M.; Pleasure, D.E.; Ikegaki, N.
cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain
Genomics
29
426-437
1995
Homo sapiens (P54762), Homo sapiens
Crosier, P.S.; Lewis, P.M.; Hall, L.R.; Vitas, M.R.; Morris, C.M.; Beier, D.R.; Wood, C.R.; Crosier, K.E.
Isolation of a receptor tyrosine kinase (DTK) from embryonic stem cells: structure, genetic mapping and analysis of expression
Growth Factors
11
125-136
1994
Mus musculus (P55144), Mus musculus
Lai, C.; Gore, M.; Lemke, G.
Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase
Oncogene
9
2567-2578
1994
Mus musculus (P55144), Mus musculus
Mark, M.R.; Scadden, D.T.; Wang, Z.; Gu, Q.; Goddard, A.; Godowski, P.J.
Rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain
J. Biol. Chem.
269
10720-10728
1994
Mus musculus (P55144), Mus musculus, Homo sapiens (Q06418), Homo sapiens
Schulz, N.T.; Paulhiac, C.I.; Lee, L.; Zhou, R.
Isolation and expression analysis of tyro3, a murine growth factor receptor tyrosine kinase preferentially expressed in adult brain
Brain Res. Mol. Brain Res.
28
273-280
1995
Mus musculus (P55144), Mus musculus
Ohashi, K.; Honda, S.; Ichinomiya, N.; Nakamura, T.; Mizuno, K.
Molecular cloning and in situ localization in the brain of rat sky receptor tyrosine kinase
J. Biochem.
117
1267-1275
1995
Rattus norvegicus (P55146)
D'Cruz, P.M.; Yasumura, D.; Weir, J.; Matthes, M.T.; Abderrahim, H.; LaVail, M.M.; Vollrath, D.
Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat
Hum. Mol. Genet.
9
645-651
2000
Rattus norvegicus (P57097)
Liu, Y.; Tolbert, E.M.; Sun, A.M.; Dworkin, L.D.
Primary structure of rat HGF receptor and induced expression in glomerular mesangial cells
Am. J. Physiol.
271
F679-688
1996
Rattus norvegicus (P97523)
Pepper, M.S.; Soriano, J.V.; Menoud, P.A.; Sappino, A.P.; Orci, L.; Montesano, R.
Modulation of hepatocyte growth factor and c-met in the rat mammary gland during pregnancy, lactation, and involution
Exp. Cell Res.
219
204-210
1995
Rattus norvegicus (P97523)
Tsujii, M.; Kawano, S.; Tsuji, S.; Ito, T.; Hayashi, N.; Horimoto, M.; Mita, E.; Nagano, K.; Masuda, E.; et al.
Increased expression of c-met messenger RNA following acute gastric injury in rats
Biochem. Biophys. Res. Commun.
200
536-541
1994
Rattus norvegicus (P97523)
Wallenius, V.R.; Rawet, H.; Skrtic, S.; Helou, K.; Qiu, Y.; Levan, G.; Ekberg, S.; Carlsson, B.; Isaksson, O.G.; Nakamura, T.; Jansson, J.O.
Chromosomal localization of rat hepatocyte growth factor (Hgf) and HGF receptor (Met) and characterization of HGF receptor cDNA
Mamm. Genome
8
661-667
1997
Rattus norvegicus (P97523)
Iwahara, T.; Fujimoto, J.; Wen, D.; Cupples, R.; Bucay, N.; Arakawa, T.; Mori, S.; Ratzkin, B.; Yamamoto, T.
Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system
Oncogene
14
439-449
1997
Mus musculus (P97793), Mus musculus
Maroc, N.; Rottapel, R.; Rosnet, O.; Marchetto, S.; Lavezzi, C.; Mannoni, P.; Birnbaum, D.; Dubreuil, P.
Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 receptor tyrosine kinase
Oncogene
8
909-918
1993
Mus musculus (Q00342), Mus musculus
Matthews, W.; Jordan, C.T.; Wiegand, G.W.; Pardoll, D.; Lemischka, I.R.
A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
Cell
65
1143-1152
1991
Mus musculus (Q00342), Mus musculus
Rosnet, O.; Marchetto, S.; deLapeyriere, O.; Birnbaum, D.
Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family
Oncogene
6
1641-1650
1991
Mus musculus (Q00342), Mus musculus
Borycki, A.G.; Guillier, M.; Leibovitch, M.P.; Leibovitch, S.A.
Molecular cloning of CSF-1 receptor from rat myoblasts. Sequence analysis and regulation during myogenesis
Growth Factors
6
209-218
1992
Rattus norvegicus (Q00495)
Faust, M.; Ebensperger, C.; Schulz, A.S.; Schleithoff, L.; Hameister, H.; Bartram, C.R.; Janssen, J.W.
The murine ufo receptor: molecular cloning, chromosomal localization and in situ expression analysis
Oncogene
7
1287-1293
1992
Mus musculus (Q00993), Mus musculus
Rescigno, J.; Mansukhani, A.; Basilico, C.
A putative receptor tyrosine kinase with unique structural topology
Oncogene
6
1909-1913
1991
Mus musculus (Q00993), Mus musculus
Avivi, A.; Lax, I.; Ullrich, A.; Schlessinger, J.; Givol, D.; Morse, B.
Comparison of EGF receptor sequences as a guide to study the ligand binding site
Oncogene
6
673-676
1991
Mus musculus (Q01279), Mus musculus
Avivi, A.; Skorecki, K.; Yayon, A.; Givol, D.
Promoter region of the murine fibroblast growth factor receptor 2 (bek/KGFR) gene
Oncogene
7
1957-1962
1992
Mus musculus (Q01279), Mus musculus
Luetteke, N.C.; Phillips, H.K.; Qiu, T.H.; Copeland, N.G.; Earp, H.S.; Jenkins, N.A.; Lee, D.C.
The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase
Genes Dev.
8
399-413
1994
Mus musculus (Q01279), Mus musculus
Paria, B.C.; Das, S.K.; Andrews, G.K.; Dey, S.K.
Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation
Proc. Natl. Acad. Sci. USA
90
55-59
1993
Mus musculus (Q01279), Mus musculus
Hovens, C.M.; Stacker, S.A.; Andres, A.C.; Harpur, A.G.; Ziemiecki, A.; Wilks, A.F.
RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs
Proc. Natl. Acad. Sci. USA
89
11818-11822
1992
Mus musculus (Q01887), Mus musculus
Kelman, Z.; Simon-Chazottes, D.; Guenet, J.L.; Yarden, Y.
The murine vik gene (chromosome 9) encodes a putative receptor with unique protein kinase motifs
Oncogene
8
37-44
1993
Mus musculus (Q01887), Mus musculus
Paul, S.R.; Merberg, D.; Finnerty, H.; Morris, G.E.; Morris, J.C.; Jones, S.S.; Kriz, R.; Turner, K.J.; Wood, C.R.
Molecular cloning of the cDNA encoding a receptor tyrosine kinase-related molecule with a catalytic region homologous to c-met
Int. J. Cell Cloning
10
309-314
1992
Mus musculus (Q01887)
Simoneaux, D.K.; Fletcher, F.A.; Jurecic, R.; Shilling, H.G.; Van, N.T.; Patel, P.; Belmont, J.W.
The receptor tyrosine kinase-related gene (ryk) demonstrates lineage and stage-specific expression in hematopoietic cells
J. Immunol.
154
1157-1166
1995
Mus musculus (Q01887), Mus musculus
Yee, K.; Bishop, T.R.; Mather, C.; Zon, L.I.
Isolation of a novel receptor tyrosine kinase cDNA expressed by developing erythroid progenitors
Blood
82
1335-1343
1993
Mus musculus (Q01887)
Masiakowski, P.; Carroll, R.D.
A novel family of cell surface receptors with tyrosine kinase-like domain
J. Biol. Chem.
267
26181-26190
1992
Homo sapiens (Q01973), Homo sapiens (Q01974), Homo sapiens
Reddy, U.R.; Phatak, S.; Pleasure, D.
Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains
Oncogene
13
1555-1559
1996
Homo sapiens (Q01973), Homo sapiens
Afzal, A.R.; Rajab, A.; Fenske, C.D.; Oldridge, M.; Elanko, N.; Ternes-Pereira, E.; Tuysuz, B.; Murday, V.A.; Patton, M.A.; Wilkie, A.O.; Jeffery, S.
Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2
Nat. Genet.
25
419-422
2000
Homo sapiens (Q01974), Homo sapiens
Oldridge, M.; Fortuna, A.M.; Maringa, M.; Propping, P.; Mansour, S.; Pollitt, C.; DeChiara, T.M.; Kimble, R.B.; Valenzuela, D.M.; Yancopoulos, G.D.; Wilkie, A.O.
Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B
Nat. Genet.
24
275-278
2000
Homo sapiens (Q01974), Homo sapiens
Schwabe, G.C.; Tinschert, S.; Buschow, C.; Meinecke, P.; Wolff, G.; Gillessen-Kaesbach, G.; Oldridge, M.; Wilkie, A.O.; Komec, R.; Mundlos, S.
Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B
Am. J. Hum. Genet.
67
822-831
2000
Homo sapiens (Q01974), Homo sapiens
Van Bokhoven, H.; Celli, J.; Kayserili, H.; van Beusekom, E.; Balci, S.; Brussel, W.; Skovby, F.; Kerr, B.; Percin, E.F.; Akarsu, N.; Brunner, H.G.
Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome
Nat. Genet.
25
423-426
2000
Homo sapiens (Q01974), Homo sapiens
Calvert, J.T.; Riney, T.J.; Kontos, C.D.; Cha, E.H.; Prieto, V.G.; Shea, C.R.; Berg, J.N.; Nevin, N.C.; Simpson, S.A.; Pasyk, K.A.; Speer, M.C.; Peters, K.G.; Marchuk, D.A.
Allelic and locus heterogeneity in inherited venous malformations
Hum. Mol. Genet.
8
1279-1289
1999
Homo sapiens (Q02763)
Vikkula, M.; Boon, L.M.; Carraway, K.L.; Calvert, J.T.; Diamonti, A.J.; Goumnerov, B.; Pasyk, K.A.; Marchuk, D.A.; Warman, M.L.; Cantley, L.C.; Mulliken, J.B.; Olsen, B.R.
Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2
Cell
87
1181-1190
1996
Homo sapiens (Q02763), Homo sapiens
Ziegler, S.F.; Bird, T.A.; Schneringer, J.A.; Schooley, K.A.; Baum, P.R.
Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta
Oncogene
8
663-670
1993
Homo sapiens (Q02763), Homo sapiens
Dumont, D.J.; Gradwohl, G.J.; Fong, G.H.; Auerbach, R.; Breitman, M.L.
The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors
Oncogene
8
1293-1301
1993
Mus musculus (Q02858), Mus musculus
Dumont, D.J.; Yamaguchi, T.P.; Conlon, R.A.; Rossant, J.; Breitman, M.L.
Tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors
Oncogene
7
1471-1480
1992
Mus musculus (Q02858), Mus musculus
Horita, K.; Yagi, T.; Kohmura, N.; Tomooka, Y.; Ikawa, Y.; Aizawa, S.
A novel tyrosine kinase, hyk, expressed in murine embryonic stem cells
Biochem. Biophys. Res. Commun.
189
1747-1753
1992
Mus musculus (Q02858), Mus musculus
Runting, A.S.; Stacker, S.A.; Wilks, A.F.
Tie2, a putative protein tyrosine kinase from a new class of cell surface receptor
Growth Factors
9
99-105
1993
Mus musculus (Q02858), Mus musculus
Sato, T.N.; Qin, Y.; Kozak, C.A.; Audus, K.L.
Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system
Proc. Natl. Acad. Sci. USA
90
9355-9358
1993
Mus musculus (Q02858), Mus musculus (Q06806), Mus musculus, Bos taurus (Q06807)
Schnurch, H.; Risau, W.
Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage
Development
119
957-968
1993
Bos taurus (Q06805), Mus musculus (Q02858), Mus musculus
Ellis, C.; Kasmi, F.; Ganju, P.; Walls, E.; Panayotou, G.; Reith, A.D.
A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn
Oncogene
12
1727-1736
1996
Mus musculus (Q03137)
Gilardi-Hebenstreit, P.; Nieto, M.A.; Frain, M.; Mattei, M.G.; Chestier, A.; Wilkinson, D.G.; Charnay, P.
An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain
Oncogene
8
1103
1993
Mus musculus (Q03137)
Stark, K.L.; McMahon, J.A.; McMahon, A.P.
FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse
Development
113
641-651
1991
Mus musculus (Q03142), Mus musculus
Ganju, P.; Shigemoto, K.; Brennan, J.; Entwistle, A.; Reith, A.D.
The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development
Oncogene
9
1613-1624
1994
Mus musculus (Q03145), Mus musculus
Perez, J.L.; Jing, S.Q.; Wong, T.W.
Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines
Oncogene
12
1469-1477
1996
Mus musculus (Q03146), Mus musculus, Homo sapiens (Q08345)
Merlio, J.P.; Ernfors, P.; Jaber, M.; Persson, H.
Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system
Neuroscience
51
513-532
1992
Rattus norvegicus (Q03351)
Tsoulfas, P.; Soppet, D.; Escandon, E.; Tessarollo, L.; Mendoza-Ramirez, J.L.; Rosenthal, A.; Nikolics, K.; Parada, L.F.
The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells
Neuron
10
975-990
1993
Rattus norvegicus (Q03351)
Valenzuela, D.M.; Maisonpierre, P.C.; Glass, D.J.; Rojas, E.; Nunez, L.; Kong, Y.; Gies, D.R.; Stitt, T.N.; Ip, N.Y.; Yancopoulos, G.D.
Alternative forms of rat TrkC with different functional capabilities
Neuron
10
963-974
1993
Rattus norvegicus (Q03351)
Friesel, R.; Brown, S.A.
Spatially restricted expression of fibroblast growth factor receptor-2 during Xenopus development
Development
116
1051-1058
1992
Xenopus laevis (Q03364), Xenopus laevis
August, A.; Gibson, S.; Kawakami, Y.; Kawakami, T.; Mills, G.B.; Dupont, B.
CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line
Proc. Natl. Acad. Sci. USA
91
9347-9351
1994
Mus musculus (Q03526)
Ching, K.A.; Kawakami, Y.; Kawakami, T.; Tsoukas, C.D.
Emt/Itk associates with activated TCR complexes: role of the pleckstrin homology domain
J. Immunol.
163
6006-6013
1999
Mus musculus (Q03526)
Heyeck, S.D.; Berg, L.J.
Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk
Proc. Natl. Acad. Sci. USA
90
669-673
1993
Mus musculus (Q03526), Mus musculus
King, P.D.; Sadra, A.; Han, A.; Liu, X.R.; Sunder-Plassmann, R.; Reinherz, E.L.; Dupont, B.
CD2 signaling in T cells involves tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK
Int. Immunol.
8
1707-1714
1996
Mus musculus (Q03526)
Siliciano, J.D.; Morrow, T.A.; Desiderio, S.V.
Itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2
Proc. Natl. Acad. Sci. USA
89
11194-11198
1992
Mus musculus (Q03526), Mus musculus
Yazaki, N.; Fujita, H.; Ohta, M.; Kawasaki, T.; Itoh, N.
The structure and expression of the FGF receptor-1 mRNA isoforms in rat tissues
Biochim. Biophys. Acta
1172
37-42
1993
Rattus norvegicus (Q04589)
Collesi, C.; Santoro, M.M.; Gaudino, G.; Comoglio, P.M.
A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype
Mol. Cell. Biol.
16
5518-5526
1996
Homo sapiens (Q04912), Homo sapiens
Ronsin, C.; Muscatelli, F.; Mattei, M.G.; Breathnach, R.
A novel putative receptor protein tyrosine kinase of the met family
Oncogene
8
1195-1202
1993
Homo sapiens (Q04912), Homo sapiens
Wang, M.H.; Ronsin, C.; Gesnel, M.C.; Coupey, L.; Skeel, A.; Leonard, E.J.; Breathnach, R.
Identification of the ron gene product as the receptor for the human macrophage stimulating protein
Science
266
117-119
1994
Homo sapiens (Q04912), Homo sapiens
Crosier, K.E.; Hall, L.R.; Lewis, P.M.; Morris, C.M.; Wood, C.R.; Morris, J.C.; Crosier, P.S.
Isolation and characterization of the human DTK receptor tyrosine kinase
Growth Factors
11
137-144
1994
Homo sapiens (Q06418), Homo sapiens
Kajii, Y.; Ninomiya, D.; Kato, M.; Mizuguchi, M.; Saji, M.; Katsumoto, T.; Ohno, K.; Takashima, S.; Onodera, K.
A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress
Biol. Cell.
88
45-54
1996
Homo sapiens (Q06418), Homo sapiens
Ohashi, K.; Mizuno, K.; Kuma, K.; Miyata, T.; Nakamura, T.
Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain
Oncogene
9
699-705
1994
Homo sapiens (Q06418), Homo sapiens
Polvi, A.; Armstrong, E.; Lai, C.; Lemke, G.; Huebner, K.; Spritz, R.A.; Guida, L.C.; Nicholls, R.D.; Alitalo, K.
The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25
Gene
134
289-293
1993
Homo sapiens (Q06418), Homo sapiens
Iwama, A.; Hamaguchi, I.; Hashiyama, M.; Murayama, Y.; Yasunaga, K.; Suda, T.
Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells
Biochem. Biophys. Res. Commun.
195
301-309
1993
Mus musculus (Q06806), Mus musculus
Korhonen, J.; Lahtinen, I.; Halmekyto, M.; Alhonen, L.; Janne, J.; Dumont, D.; Alitalo, K.
Endothelial-specific gene expression directed by the tie gene promoter in vivo
Blood
86
1828-1835
1995
Mus musculus (Q06806), Mus musculus
Ito, M.; Matsui, T.; Taniguchi, T.; Chihara, K.
Alternative splicing generates two distinct transcripts for the Drosophila melanogaster fibroblast growth factor receptor homolog
Gene
139
215-218
1994
Drosophila melanogaster (Q07407), Drosophila melanogaster
Shishido, E.; Higashijima, S.; Emori, Y.; Saigo, K.
Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos
Development
117
751-761
1993
Drosophila melanogaster (Q07407), Drosophila melanogaster (Q09147)
Ohta, K.; Nakamura, M.; Hirokawa, K.; Tanaka, S.; Iwama, A.; Suda, T.; Ando, M.; Tanaka, H.
The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development
Mech. Dev.
54
59-69
1996
Gallus gallus (Q07496)
Soans, C.; Holash, J.A.; Pavlova, Y.; Pasquale, E.B.
Developmental expression and distinctive tyrosine phosphorylation of the Eph-related receptor tyrosine kinase Cek9
J. Cell Biol.
135
781-795
1996
Gallus gallus (Q07497), Gallus gallus
Sasaki, E.; Okamura, H.; Chikamune, T.; Kanai, Y.; Watanabe, M.; Naito, M.; Sakurai, M.
Cloning and expression of the chicken c-kit proto-oncogene
Gene
128
257-261
1993
Gallus gallus (Q08156), Gallus gallus
Di Marco, E.; Cutuli, N.; Guerra, L.; Cancedda, R.; De Luca, M.
Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues
J. Biol. Chem.
268
24290-24295
1993
Homo sapiens (Q08345), Homo sapiens
Johnson, J.D.; Edman, J.C.; Rutter, W.J.
A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain
Proc. Natl. Acad. Sci. USA
90
5677-5681
1993
Homo sapiens (Q08345)
Laval, S.; Butler, R.; Shelling, A.N.; Hanby, A.M.; Poulsom, R.; Ganesan, T.S.
Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line
Cell Growth Differ.
5
1173-1183
1994
Homo sapiens (Q08345)
Perez, J.L.; Shen, X.; Finkernagel, S.; Sciorra, L.; Jenkins, N.A.; Gilbert, D.J.; Copeland, N.G.; Wong, T.W.
Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain
Oncogene
9
211-219
1994
Homo sapiens (Q08345), Homo sapiens
Playford, M.P.; Butler, R.J.; Wang, X.C.; Katso, R.M.; Cooke, I.E.; Ganesan, T.S.
The genomic structure of discoidin receptor tyrosine kinase
Genome Res.
6
620-627
1996
Homo sapiens (Q08345), Homo sapiens
Glazer, L.; Shilo, B.Z.
The Drosophila FGF-R homolog is expressed in the embryonic tracheal system and appears to be required for directed tracheal cell extension
Genes Dev.
5
697-705
1991
Drosophila melanogaster (Q09147)
Klambt, C.; Glazer, L.; Shilo, B.Z.
breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells
Genes Dev.
6
1668-1678
1992
Drosophila melanogaster (Q09147)
Shishido, E.; Emori, Y.; Saigo, K.
Identification of seven novel protein-tyrosine kinase genes of Drosophila by the polymerase chain reaction
FEBS Lett.
289
235-238
1991
Drosophila melanogaster (Q07407), Drosophila melanogaster (Q09147), Drosophila melanogaster
Gal, A.; Li, Y.; Thompson, D.A.; Weir, J.; Orth, U.; Jacobson, S.G.; Apfelstedt-Sylla, E.; Vollrath, D.
Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa
Nat. Genet.
26
270-271
2000
Homo sapiens (Q12866), Homo sapiens
Graham, D.K.; Dawson, T.L.; Mullaney, D.L.; Snodgrass, H.R.; Earp, H.S.
Cloning and mRNA expression analysis of a novel human protooncogene, c-mer
Cell Growth Differ.
5
647-657
1994
Homo sapiens (Q12866), Homo sapiens
Elenius, K.; Corfas, G.; Paul, S.; Choi, C.J.; Rio, C.; Plowman, G.D.; Klagsbrun, M.
A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester
J. Biol. Chem.
272
26761-26768
1997
Homo sapiens (Q15303), Homo sapiens
Garcia, R.A.; Vasudevan, K.; Buonanno, A.
The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses
Proc. Natl. Acad. Sci. USA
97
3596-3601
2000
Homo sapiens (Q15303)
Plowman, G.D.; Culouscou, J.M.; Whitney, G.S.; Green, J.M.; Carlton, G.W.; Foy, L.; Neubauer, M.G.; Shoyab, M.
Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family
Proc. Natl. Acad. Sci. USA
90
1746-1750
1993
Homo sapiens (Q15303), Homo sapiens
McGregor, L.M.; Baylin, S.B.; Griffin, C.A.; Hawkins, A.L.; Nelkin, B.D.
Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant
Genomics
22
267-272
1994
Homo sapiens (Q16288), Homo sapiens
Shelton, D.L.; Sutherland, J.; Gripp, J.; Camerato, T.; Armanini, M.P.; Phillips, H.S.; Carroll, K.; Spencer, S.D.; Levinson, A.D.
Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins
J. Neurosci.
15
477-491
1995
Homo sapiens (Q16288), Homo sapiens (Q16620)
Allen, S.J.; Dawbarn, D.; Eckford, S.D.; Wilcock, G.K.; Ashcroft, M.; Colebrook, S.M.; Feeney, R.; MacGowan, S.H.
Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain
Neuroscience
60
825-834
1994
Homo sapiens (Q16620), Homo sapiens
Nakagawara, A.; Liu, X.G.; Ikegaki, N.; White, P.S.; Yamashiro, D.J.; Nycum, L.M.; Biegel, J.A.; Brodeur, G.M.
Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2)
Genomics
25
538-546
1995
Homo sapiens (Q16620), Homo sapiens
Stoilov, P.; Castren, E.; Stamm, S.
Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism
Biochem. Biophys. Res. Commun.
290
1054-1065
2002
Homo sapiens (Q16620), Homo sapiens
Karn, T.; Holtrich, U.; Brauninger, A.; Bohme, B.; Wolf, G.; Rubsamen-Waigmann, H.; Strebhardt, K.
Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain
Oncogene
8
3433-3440
1993
Homo sapiens (Q16832), Homo sapiens, Mus musculus (Q62371), Mus musculus
Wilson, C.; Goberdhan, D.C.; Steller, H.
Dror, a potential neurotrophic receptor gene, encodes a Drosophila homolog of the vertebrate Ror family of Trk-related receptor tyrosine kinases
Proc. Natl. Acad. Sci. USA
90
7109-7113
1993
Drosophila melanogaster (Q24488)
Callahan, C.A.; Bonkovsky, J.L.; Scully, A.L.; Thomas, J.B.
Derailed is required for muscle attachment site selection in Drosophila
Development
122
2761-2767
1996
Drosophila melanogaster (Q27324)
Callahan, C.A.; Muralidhar, M.G.; Lundgren, S.E.; Scully, A.L.; Thomas, J.B.
Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member
Nature
376
171-174
1995
Drosophila melanogaster (Q27324)
Dura, J.M.; Taillebourg, E.; Preat, T.
The Drosophila learning and memory gene linotte encodes a putative receptor tyrosine kinase homologous to the human RYK gene product
FEBS Lett.
370
250-254
1995
Drosophila melanogaster (Q27324)
Taillebourg, E.; Dura, J.M.
A novel mechanism for P element homing in Drosophila
Proc. Natl. Acad. Sci. USA
96
6856-6861
1999
Drosophila melanogaster (Q27324)
Gamulin, V.; Rinkevich, B.; Schacke, H.; Kruse, M.; Muller, I.M.; Muller, W.E.
Cell adhesion receptors and nuclear receptors are highly conserved from the lowest metazoa (marine sponges) to vertebrates
Biol. Chem. Hoppe-Seyler
375
583-588
1994
Geodia cydonium (Q27656), Geodia cydonium
Gamulin, V.; Skorokhod, A.; Kavsan, V.; Muller, I.M.; Muller, W.E.
Experimental indication in favor of the introns-late theory: the receptor tyrosine kinase gene from the sponge Geodia cydonium
J. Mol. Evol.
44
242-252
1997
Geodia cydonium (Q27656), Geodia cydonium
Schacke, H.; Rinkevich, B.; Gamulin, V.; Muller, I.M.; Muller, W.E.
Immunoglobulin-like domain is present in the extracellular part of the receptor tyrosine kinase from the marine sponge Geodia cydonium
J. Mol. Recognit.
7
273-276
1994
Geodia cydonium (Q27656), Geodia cydonium
Tanaka, S.; Yanagisawa, N.; Tojo, H.; Kim, Y.J.; Tsujimura, T.; Kitamura, Y.; Sawasaki, T.; Tachi, C.
Molecular cloning of cDNA encoding the c-kit receptor of Shiba goats and a novel alanine insertion specific to goats and sheep in the kinase insert region
Biochim. Biophys. Acta
1352
151-155
1997
Capra hircus (Q28317), Capra hircus
Herbst, R.; Munemitsu, S.; Ullrich, A.
Oncogenic activation of v-kit involves deletion of a putative tyrosine-substrate interaction site
Oncogene
10
369-379
1995
Felis silvestris (Q28889)
Nakamura, T.; Ushijima, T.; Ishizaka, Y.; Nagao, M.; Arai, M.; Yamazaki, Y.; Ishikawa, T.
Cloning and activation of the Syrian hamster neu proto-oncogene
Gene
140
251-255
1994
Mesocricetus auratus (Q60553), Mesocricetus auratus
Zhou, R.; Copeland, T.D.; Kromer, L.F.; Schulz, N.T.
Isolation and characterization of Bsk, a growth factor receptor-like tyrosine kinase associated with the limbic system
J. Neurosci. Res.
37
129-143
1994
Mus musculus (Q60629), Mus musculus
Graham, D.K.; Bowman, G.W.; Dawson, T.L.; Stanford, W.L.; Earp, H.S.; Snodgrass, H.R.
Cloning and developmental expression analysis of the murine c-mer tyrosine kinase
Oncogene
10
2349-2359
1995
Mus musculus (Q60805), Mus musculus
Ciossek, T.; Millauer, B.; Ullrich, A.
Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system
Oncogene
10
97-108
1995
Mus musculus (Q61772), Mus musculus
Ellis, J.; Liu, Q.; Breitman, M.; Jenkins, N.A.; Gilbert, D.J.; Copeland, N.G.; Tempest, H.V.; Warren, S.; Muir, E.; Schilling, H.; et al.
Embryo brain kinase: a novel gene of the eph/elk receptor tyrosine kinase family
Mech. Dev.
52
319-341
1995
Mus musculus (Q61772), Mus musculus
Chellaiah, A.T.; McEwen, D.G.; Werner, S.; Xu, J.; Ornitz, D.M.
Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1
J. Biol. Chem.
269
11620-11627
1994
Mus musculus (Q61851)
Katoh, O.; Hattori, Y.; Sasaki, H.; Sakamoto, H.; Fujimoto, K.; Fujii, T.; Sugimura, T.; Terada, M.
Isolation of the complementary DNA encoding a mouse heparin-binding growth factor receptor with the use of a unique kinase insert sequence
Cancer Res.
53
1136-1141
1993
Mus musculus (Q61851), Mus musculus
Ornitz, D.M.; Leder, P.
Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3
J. Biol. Chem.
267
16305-16311
1992
Mus musculus (Q61851), Mus musculus
Iwama, A.; Okano, K.; Sudo, T.; Matsuda, Y.; Suda, T.
Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells
Blood
83
3160-3169
1994
Mus musculus (Q62190), Mus musculus
Waltz, S.E.; Toms, C.L.; McDowell, S.A.; Clay, L.A.; Muraoka, R.S.; Air, E.L.; Sun, W.Y.; Thomas, M.B.; Degen, S.J.
Characterization of the mouse Ron/Stk receptor tyrosine kinase gene
Oncogene
16
27-42
1998
Mus musculus (Q62190), Mus musculus
Lai, C.; Lemke, G.
Structure and expression of the Tyro 10 receptor tyrosine kinase
Oncogene
9
877-883
1994
Mus musculus (Q62371)
Olaso, E.; Labrador, J.P.; Wang, L.; Ikeda, K.; Eng, F.J.; Klein, R.; Lovett, D.H.; Lin, H.C.; Friedman, S.L.
Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2
J. Biol. Chem.
277
3606-3613
2002
Mus musculus (Q62371)
Lee, A.M.; Navaratnam, D.; Ichimiya, S.; Greene, M.I.; Davis, J.G.
Cloning of m-ehk2 from the murine inner ear, an eph family receptor tyrosine kinase expressed in the developing and adult cochlea
DNA Cell Biol.
15
817-825
1996
Mus musculus (Q62413), Mus musculus
Carroll, S.L.; Miller, M.L.; Frohnert, P.W.; Kim, S.S.; Corbett, J.A.
Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration
J. Neurosci.
17
1642-1659
1997
Rattus norvegicus (Q62799), Rattus norvegicus (Q62956)
Hellyer, N.J.; Kim, H.H.; Greaves, C.H.; Sierke, S.L.; Koland, J.G.
Cloning of the rat ErbB3 cDNA and characterization of the recombinant protein
Gene
165
279-284
1995
Rattus norvegicus (Q62799)
Zhao, Y.Y.; Sawyer, D.R.; Baliga, R.R.; Opel, D.J.; Han, X.; Marchionni, M.A.; Kelly, R.A.
Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes
J. Biol. Chem.
273
10261-10269
1998
Rattus norvegicus (Q62956)
Sanchez, M.P.; Tapley, P.; Saini, S.S.; He, B.; Pulido, D.; Barbacid, M.
Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain
Proc. Natl. Acad. Sci. USA
91
1819-1823
1994
Rattus norvegicus (Q63474)
Middlemas, D.S.; Lindberg, R.A.; Hunter, T.
TrkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors
Mol. Cell. Biol.
11
143-153
1991
Rattus norvegicus (Q63604)
Middlemas, D.S.; Meisenhelder, J.; Hunter, T.
Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor
J. Biol. Chem.
269
5458-5466
1994
Rattus norvegicus (Q63604)
Kenny, D.; Bronner-Fraser, M.; Marcelle, C.
The receptor tyrosine kinase QEK5 mRNA is expressed in a gradient within the neural retina and the tectum
Dev. Biol.
172
708-716
1995
Coturnix japonica (Q90344)
Jones, T.L.; Karavanova, I.; Maeno, M.; Ong, R.C.; Kung, H.F.; Daar, I.O.
Expression of an amphibian homolog of the Eph family of receptor tyrosine kinases is developmentally regulated
Oncogene
10
1111-1117
1995
Xenopus laevis (Q91571)
Winning, R.S.; Sargent, T.D.
Pagliaccio, a member of the Eph family of receptor tyrosine kinase genes, has localized expression in a subset of neural crest and neural tissues in Xenopus laevis embryos
Mech. Dev.
46
219-229
1994
Xenopus laevis (Q91694), Xenopus laevis
Scales, J.B.; Winning, R.S.; Renaud, C.S.; Shea, L.J.; Sargent, T.D.
Novel members of the eph receptor tyrosine kinase subfamily expressed during Xenopus development
Oncogene
11
1745-1752
1995
Xenopus laevis (Q91735)
Shiozaki, C.; Tashiro, K.; Asano-Miyoshi, M.; Saigo, K.; Emori, Y.; Shiokawa, K.
Cloning of cDNA and genomic DNA encoding fibroblast growth factor receptor-4 of Xenopus laevis
Gene
152
215-219
1995
Xenopus laevis (Q91742), Xenopus laevis
Xu, Q.; Alldus, G.; Holder, N.; Wilkinson, D.G.
Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain
Development
121
4005-4016
1995
Xenopus laevis (Q91845)
Graf, R.; Neuenschwander, S.; Brown, M.R.; Ackermann, U.
Insulin-mediated secretion of ecdysteroids from mosquito ovaries and molecular cloning of the insulin receptor homologue from ovaries of bloodfed Aedes aegypti
Insect Mol. Biol.
6
151-163
1997
Aedes aegypti (Q93105), Aedes aegypti
Oates, A.C.; Bonkovsky, J.L.; Irvine, D.V.; Kelly, L.E.; Thomas, J.B.; Wilks, A.F.
Embryonic expression and activity of doughnut, a second RYK homolog in Drosophila
Mech. Dev.
78
165-169
1998
Drosophila melanogaster (Q9v422)
Savant-Bhonsale, S.; Friese, M.; McCoon, P.; Montell, D.J.
A Drosophila derailed homolog, doughnut, expressed in invaginating cells during embryogenesis
Gene
231
155-161
1999
Drosophila melanogaster (Q9v422)
Oishi, I.; Sugiyama, S.; Liu, Z.J.; Yamamura, H.; Nishida, Y.; Minami, Y.
A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. Unique structural features and implication in developmental signaling
J. Biol. Chem.
272
11916-11923
1997
Drosophila melanogaster (Q9v6k3)
Sugaya, R.; Ishimaru, S.; Hosoya, T.; Saigo, K.; Emori, Y.
A Drosophila homolog of human proto-oncogene ret transiently expressed in embryonic neuronal precursor cells including neuroblasts and CNS cells
Mech. Dev.
45
139-145
1994
Drosophila melanogaster (Q9vie4)
Hirayama, I.; Tamemoto, H.; Yokota, H.; Kubo, S.K.; Wang, J.; Kuwano, H.; Nagamachi, Y.; Takeuchi, T.; Izumi, T.
Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2
Diabetes
48
1237-1244
1999
Mus musculus (Q9wtl4), Mus musculus
DeChiara, T.M.; Kimble, R.B.; Poueymirou, W.T.; Rojas, J.; Masiakowski, P.; Valenzuela, D.M.; Yancopoulos, G.D.
Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development
Nat. Genet.
24
271-274
2000
Mus musculus (Q9z138), Mus musculus
Oishi, I.; Takeuchi, S.; Hashimoto, R.; Nagabukuro, A.; Ueda, T.; Liu, Z.J.; Hatta, T.; Akira, S.; Matsuda, Y.; Yamamura, H.; Otani, H.; Minami, Y.
Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system
Genes Cells
4
41-56
1999
Mus musculus (Q9z138), Mus musculus (Q9z139), Mus musculus
Hunter, T.
Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling
Cell
80
225-236
1995
eukaryota
Kemp, B.E.; Parker, M.W.; Hu, S.; Tiganis, T.; House, C.
Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity
Trends Biochem. Sci.
19
440-444
1994
Mammalia
Adams Joseph, A.
Activation loop phosphorylation and catalysis in protein kinases: is there functional evidence for the autoinhibitor model?
Biochemistry
42
601-607
2003
eukaryota
Kawai, J.; Shinagawa, A.; Shibata, K.; Yoshino, M.; Itoh, M.; et al.
Functional annotation of a full-length mouse cDNA collection
Nature
409
685-690
2001
Mus musculus (P09581)
Ren, Z.; Baumgarten, C.M.
Antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases
Am. J. Physiol.
288
H2628-2636
2005
Oryctolagus cuniculus
Gargala, G.; Baishanbo, A.; Favennec, L.; Francois, A.; Ballet, J.J.; Rossignol, J.F.
Inhibitory activities of epidermal growth factor receptor tyrosine kinase-targeted dihydroxyisoflavone and trihydroxydeoxybenzoin derivatives on Sarcocystis neurona, Neospora caninum, and Cryptosporidium parvum development
Antimicrob. Agents Chemother.
49
4628-4634
2005
Cryptosporidium parvum, Meriones unguiculatus, Homo sapiens, Neospora caninum, Sarcocystis neurona
Aslan, M.; Ozben, T.
Oxidants in receptor tyrosine kinase signal transduction pathways
Antioxid. Redox Signal.
5
781-788
2003
Bos taurus, Homo sapiens
Mehdi, M.Z.; Pandey, N.R.; Pandey, S.K.; Srivastava, A.K.
H2O2-induced phosphorylation of ERK1/2 and PKB requires tyrosine kinase activity of insulin receptor and c-Src
Antioxid. Redox Signal.
7
1014-1020
2005
Homo sapiens
Droge, W.
Oxidative enhancement of insulin receptor signaling: experimental findings and clinical implications
Antioxid. Redox Signal.
7
1071-1077
2005
Homo sapiens
Roskoski, R.Jr.
The ErbB/HER receptor protein-tyrosine kinases and cancer
Biochem. Biophys. Res. Commun.
319
1-11
2004
Homo sapiens
Roskoski, R.Jr.
Signaling by Kit protein-tyrosine kinase - the stem cell factor receptor
Biochem. Biophys. Res. Commun.
337
1-13
2005
Homo sapiens, Mus musculus
Roskoski, R.Jr.
Structure and regulation of Kit protein-tyrosine kinase - the stem cell factor receptor
Biochem. Biophys. Res. Commun.
338
1307-1315
2005
Homo sapiens
Randi, A.S.; Sancovich, H.A.; Ferramola de Sancovich, A.M.; Loaiza, A.; Kolliker Frers, R.A.; Spinelli, F.; Kleiman de Pisarev, D.L.
Effect of in vivo administered hexachlorobenzene on epidermal growth factor receptor levels, protein tyrosine kinase activity, and phosphotyrosine content in rat liver
Biochem. Pharmacol.
65
1495-1506
2003
Rattus norvegicus
Holland, W.; Morrison, T.; Chang, Y.; Wiernsperger, N.; Stith, B.J.
Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase
Biochem. Pharmacol.
67
2081-2091
2004
Homo sapiens, Xenopus laevis
Lee, L.T.; Huang, Y.T.; Hwang, J.J.; Lee, A.Y.; Ke, F.C.; Huang, C.J.; Kandaswami, C.; Lee, P.P.; Lee, M.T.
Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells
Biochem. Pharmacol.
67
2103-2114
2004
Homo sapiens
Sheth, P.R.; Watowich, S.J.
Oligomerization-induced differential dephosphorylation of c-Met receptor tyrosine kinase
Biochemistry
44
10984-10993
2005
Homo sapiens
Wang, H.; Kruszewski, A.; Brautigan, D.L.
Cellular chromium enhances activation of insulin receptor kinase
Biochemistry
44
8167-8175
2005
Homo sapiens
Ruschel, A.; Ullrich, A.
Protein tyrosine kinase Syk modulates EGFR signalling in human mammary epithelial cells
Cell. Signal.
16
1249-1261
2004
Homo sapiens
Asano, T.; Nakamura, H.; Uehara, Y.; Yamamoto, Y.
Design, synthesis, and biological evaluation of aminoboronic acids as growth-factor receptor inhibitors of EGFR and VEGFR-1 tyrosine kinases
ChemBioChem
5
483-490
2004
Homo sapiens
Medinger, M.; Drevs, J.
Receptor tyrosine kinases and anticancer therapy
Curr. Pharm. Des.
11
1139-1149
2005
Homo sapiens
Mergler, S.; Dannowski, H.; Bednarz, J.; Engelmann, K.; Hartmann, C.; Pleyer, U.
Calcium influx induced by activation of receptor tyrosine kinases in SV40-transfected human corneal endothelial cells
Exp. Eye Res.
77
485-495
2003
Homo sapiens
Fang, Y.; Han, S.I.; Mitchell, C.; Gupta, S.; Studer, E.; Grant, S.; Hylemon, P.B.; Dent, P.
Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes
Hepatology
40
961-971
2004
Rattus norvegicus
Haj, F.G.; Markova, B.; Klaman, L.D.; Bohmer, F.D.; Neel, B.G.
Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B
J. Biol. Chem.
278
739-744
2003
Mus musculus
Meyer, A.N.; Gastwirt, R.F.; Schlaepfer, D.D.; Donoghue, D.J.
The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation
J. Biol. Chem.
279
28450-28457
2004
Homo sapiens
Mol, C.D.; Dougan, D.R.; Schneider, T.R.; Skene, R.J.; Kraus, M.L.; Scheibe, D.N.; Snell, G.P.; Zou, H.; Sang, B.C.; Wilson, K.P.
Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase
J. Biol. Chem.
279
31655-31663
2004
Homo sapiens (P10721), Homo sapiens
Wu, J.H.; Goswami, R.; Kim, L.K.; Miller, W.E.; Peppel, K.; Freedman, N.J.
The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition
J. Biol. Chem.
280
31027-31035
2005
Homo sapiens
Du, X.L.; Gao, Z.; Lau, C.P.; Chiu, S.W.; Tse, H.F.; Baumgarten, C.M.; Li, G.R.
Differential effects of tyrosine kinase inhibitors on volume-sensitive chloride current in human atrial myocytes: evidence for dual regulation by Src and EGFR kinases
J. Gen. Physiol.
123
427-439
2004
Homo sapiens
McLaughlin, S.; Smith, S.O.; Hayman, M.J.; Murray, D.
An electrostatic engine model for autoinhibition and activation of the epidermal growth factor receptor (EGFR/ErbB) family
J. Gen. Physiol.
126
41-53
2005
Homo sapiens (P00533)
Werry, T.D.; Gregory, K.J.; Sexton, P.M.; Christopoulos, A.
Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2
J. Neurochem.
93
1603-1615
2005
Homo sapiens
Wang, C.; Buck, D.C.; Yang, R.; Macey, T.A.; Neve, K.A.
Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases
J. Neurochem.
93
899-909
2005
Homo sapiens
Varkondi, E.; Schaefer, E.; Boekoenyi, G.; Gyoekeres, T.; Oerfi, L.; Petak, I.; Pap, A.; Szokoloczi, O.; Keri, G.; Schwab, R.
Comparison of ELISA-based tyrosine kinase assays for screening EGFR inhibitors
J. Recept. Signal Transduct. Res.
25
45-56
2005
Homo sapiens
Benter, I.F.; Juggi, J.S.; Khan, I.; Yousif, M.H.M.; Canatan, H.; Akhtar, S.
Signal transduction mechanisms involved in cardiac preconditioning: role of Ras-GTPase, Ca2+/calmodulin-dependent protein kinase II and epidermal growth factor receptor
Mol. Cell. Biochem.
268
175-183
2005
Rattus norvegicus
Schmidt-Arras, D.E.; Bohmer, A.; Markova, B.; Choudhary, C.; Serve, H.; Bohmer, F.D.
Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases
Mol. Cell. Biol.
25
3690-3703
2005
Homo sapiens
South, S.L.; Nichols, R.; Montie, T.C.
Tyrosine kinase activity in Pseudomonas aeruginosa
Mol. Microbiol.
12
903-910
1994
Pseudomonas aeruginosa
Hupfeld, C.J.; Olefsky, J.M.
Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins
Annu. Rev. Physiol.
69
561-577
2007
Homo sapiens, Mus musculus, Rattus norvegicus
Kumar, P.; Ferns, M.J.; Meizel, S.
Identification of agrinSN isoform and muscle-specific receptor tyrosine kinase (MuSK) [corrected] in sperm
Biochem. Biophys. Res. Commun.
342
522-528
2006
Homo sapiens, Mus musculus
Cote, M.; Miller, A.D.; Liu, S.L.
Human RON receptor tyrosine kinase induces complete epithelial-to-mesenchymal transition but causes cellular senescence
Biochem. Biophys. Res. Commun.
360
219-225
2007
Homo sapiens
Li, E.; Hristova, K.
Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies
Biochemistry
45
6241-6251
2006
Homo sapiens
Ballard, P.; Barlaam, B.C.; Bradbury, R.H.; Dishington, A.; Hennequin, L.F.; Hickinson, D.M.; Hollingsworth, I.M.; Kettle, J.G.; Klinowska, T.; Ogilvie, D.J.; Pearson, S.E.; Scott, J.S.; Suleman, A.; Whittaker, R.; Williams, E.J.; Wood, R.; Wright, L.
Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase
Bioorg. Med. Chem. Lett.
17
6326-6329
2007
Mus musculus
Corbacioglu, S.; Kilic, M.; Westhoff, M.A.; Reinhardt, D.; Fulda, S.; Debatin, K.M.
Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin
Blood
108
3504-3513
2006
Homo sapiens
Bernstein, H.G.; Lendeckel, U.; Bertram, I.; Bukowska, A.; Kanakis, D.; Dobrowolny, H.; Stauch, R.; Krell, D.; Mawrin, C.; Budinger, E.; Keilhoff, G.; Bogerts, B.
Localization of neuregulin-1alpha (heregulin-alpha) and one of its receptors, ErbB-4 tyrosine kinase, in developing and adult human brain
Brain Res. Bull.
69
546-559
2006
Homo sapiens, Rattus norvegicus
Camp, E.R.; Yang, A.; Gray, M.J.; Fan, F.; Hamilton, S.R.; Evans, D.B.; Hooper, A.T.; Pereira, D.S.; Hicklin, D.J.; Ellis, L.M.
Tyrosine kinase receptor RON in human pancreatic cancer: expression, function, and validation as a target
Cancer
109
1030-1039
2007
Homo sapiens
Lu, Y.; Yao, H.P.; Wang, M.H.
Multiple variants of the RON receptor tyrosine kinase: Biochemical properties, tumorigenic activities, and potential drug targets
Cancer Lett.
257
157-164
2007
Homo sapiens
Carey, K.D.; Garton, A.J.; Romero, M.S.; Kahler, J.; Thomson, S.; Ross, S.; Park, F.; Haley, J.D.; Gibson, N.; Sliwkowski, M.X.
Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib
Cancer Res.
66
8163-8171
2006
Homo sapiens
Thomas, R.M.; Toney, K.; Fenoglio-Preiser, C.; Revelo-Penafiel, M.P.; Hingorani, S.R.; Tuveson, D.A.; Waltz, S.E.; Lowy, A.M.
The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression
Cancer Res.
67
6075-6082
2007
Homo sapiens, Mus musculus
Schlessinger, J.; Lemmon, M.A.
Nuclear signaling by receptor tyrosine kinases: the first robin of spring
Cell
127
45-48
2006
Homo sapiens
Bazigou, E.; Apitz, H.; Johansson, J.; Loren, C.E.; Hirst, E.M.; Chen, P.L.; Palmer, R.H.; Salecker, I.
Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila
Cell
128
961-975
2007
Drosophila melanogaster
Niemann, H.H.; Jaeger, V.; Butler, P.J.; van den Heuvel, J.; Schmidt, S.; Ferraris, D.; Gherardi, E.; Heinz, D.W.
Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB
Cell
130
235-246
2007
Homo sapiens (P08581), Homo sapiens
Mehdi, M.Z.; Azar, Z.M.; Srivastava, A.K.
Role of receptor and nonreceptor protein tyrosine kinases in H2O2-induced PKB and ERK1/2 signaling
Cell Biochem. Biophys.
47
1-10
2007
Homo sapiens, Rattus norvegicus, Sus scrofa
Hussein, M.R.
Expression of KIT receptor tyrosine kinase protein in normal human skin: preliminary observations
Cell Biol. Int.
31
748-751
2007
Homo sapiens
Tyndall, S.J.; Walikonis, R.S.
The receptor tyrosine kinase Met and its ligand hepatocyte growth factor are clustered at excitatory synapses and can enhance clustering of synaptic proteins
Cell Cycle
5
1560-1568
2006
Homo sapiens
Ingram, J.L.; Bonner, J.C.
EGF and PDGF receptor tyrosine kinases as therapeutic targets for chronic lung diseases
Curr. Mol. Med.
6
409-421
2006
Rattus norvegicus
Hubbard, S.R.; Miller, W.T.
Receptor tyrosine kinases: mechanisms of activation and signaling
Curr. Opin. Cell Biol.
19
117-123
2007
Drosophila melanogaster, Homo sapiens
Hafizi, S.; Dahlbaeck, B.
Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily
FEBS J.
273
5231-5244
2006
Homo sapiens, Rattus norvegicus
Vernersson, E.; Khoo, N.K.; Henriksson, M.L.; Roos, G.; Palmer, R.H.; Hallberg, B.
Characterization of the expression of the ALK receptor tyrosine kinase in mice
Gene Expr. Patterns
6
448-461
2006
Mus musculus
Edling, C.E.; Hallberg, B.
c-Kit - A hematopoietic cell essential receptor tyrosine kinase
Int. J. Biochem. Cell Biol.
39
1995-1998
2007
Homo sapiens
Rees, K.A.; Singh, H.; Brindle, N.P.
The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines
Int. J. Oncol.
31
893-897
2007
Homo sapiens
McGarrigle, D.; Shan, D.; Yang, S.; Huang, X.Y.
Role of tyrosine kinase Csk in G protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration
J. Biol. Chem.
281
10583-10588
2006
Mus musculus
Tanos, B.; Pendergast, A.M.
Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor
J. Biol. Chem.
281
32714-32723
2006
Homo sapiens
Tapinos, N.; Ohnishi, M.; Rambukkana, A.
ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli
Nat. Med.
12
961-966
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Li, L.; Su, Y.; Zhao, C.; Zhao, H.; Liu, G.; Wang, J.; Xu, Q.
The role of Ret receptor tyrosine kinase in dopaminergic neuron development
Neuroscience
142
391-400
2006
Rattus norvegicus
Yoon, S.J.; Nakayama, K.; Hikita, T.; Handa, K.; Hakomori, S.I.
Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor
Proc. Natl. Acad. Sci. USA
103
18987-18991
2006
Homo sapiens
Lentsch, A.B.; Pathrose, P.; Kader, S.; Kuboki, S.; Collins, M.H.; Waltz, S.E.
The Ron receptor tyrosine kinase regulates acute lung injury and suppresses nuclear factor kappaB activation
Shock
27
274-280
2007
Mus musculus
Ewan, L.C.; Jopling, H.M.; Jia, H.; Mittar, S.; Bagherzadeh, A.; Howell, G.J.; Walker, J.H.; Zachary, I.C.; Ponnambalam, S.
Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells
Traffic
7
1270-1282
2006
Homo sapiens
Mason, J.M.; Morrison, D.J.; Basson, M.A.; Licht, J.D.
Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling
Trends Cell Biol.
16
45-54
2006
Drosophila melanogaster, Homo sapiens, Mus musculus
Zeren, T.; Inan, S.; Seda Vatansever, H.; Ekerbicer, N.; Sayhan, S.
Significance of tyrosine kinase activity on malign transformation of ovarian tumors: a comparison between EGF-R and TGF-alpha
Acta Histochem.
110
256-263
2008
Homo sapiens
Wagh, P.K.; Peace, B.E.; Waltz, S.E.
Met-related receptor tyrosine kinase Ron in tumor growth and metastasis
Adv. Cancer Res.
100
1-33
2008
Bos taurus, Canis lupus, Gallus gallus, Equus caballus, Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus, Strongylocentrotus purpuratus, Takifugu rubripes
Moulder, S.L.; Craft, B.S.; Hortobagyi, G.N.
Inhibition of receptor tyrosine kinases in combination with chemotherapy for the treatment of breast cancer
Anticancer Agents Med. Chem.
8
481-487
2008
Homo sapiens
Sheth, P.R.; Hays, J.L.; Elferink, L.A.; Watowich, S.J.
Biochemical basis for the functional switch that regulates hepatocyte growth factor receptor tyrosine kinase activation
Biochemistry
47
4028-4038
2008
Chlorocebus aethiops (Q2IBA6)
Haga, Y.; Hatanaka, K.; Hakomori, S.I.
Effect of lipid mimetics of GM3 and lyso-GM3 dimer on EGF receptor tyrosine kinase and EGF-induced signal transduction
Biochim. Biophys. Acta
1780
393-404
2008
Homo sapiens
Barlaam, B.; Acton, D.G.; Ballard, P.; Bradbury, R.H.; Cross, D.; Ducray, R.; Germain, H.; Hudson, K.; Klinowska, T.; Magnien, F.; Ogilvie, D.J.; Olivier, A.; Ross, H.S.; Smith, R.; Trigwell, C.B.; Vautier, M.; Wright, L.
Neutral 5-substituted 4-indazolylaminoquinazolines as potent, orally active inhibitors of ErbB2 receptor tyrosine kinase
Bioorg. Med. Chem. Lett.
18
1799-1803
2008
Homo sapiens (P04626), Homo sapiens
Usui, T.; Ban, H.S.; Kawada, J.; Hirokawa, T.; Nakamura, H.
Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening
Bioorg. Med. Chem. Lett.
18
285-288
2008
Homo sapiens (P00533), Homo sapiens (P35968)
Xu, G.; Searle, L.L.; Hughes, T.V.; Beck, A.K.; Connolly, P.J.; Abad, M.C.; Neeper, M.P.; Struble, G.T.; Springer, B.A.; Emanuel, S.L.; Gruninger, R.H.; Pandey, N.; Adams, M.; Moreno-Mazza, S.; Fuentes-Pesquera, A.R.; Middleton, S.A.; Greenberger, L.M.
Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases
Bioorg. Med. Chem. Lett.
18
3495-3499
2008
Homo sapiens (P00533), Homo sapiens (P04626)
Barlaam, B.; Ballard, P.; Bradbury, R.H.; Ducray, R.; Germain, H.; Hickinson, D.M.; Hudson, K.; Kettle, J.G.; Klinowska, T.; Magnien, F.; Ogilvie, D.J.; Olivier, A.; Pearson, S.E.; Scott, J.S.; Suleman, A.; Trigwell, C.B.; Vautier, M.; Whittaker, R.D.; Wood, R.
A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase
Bioorg. Med. Chem. Lett.
18
674-678
2008
Homo sapiens
Mudduluru, G.; Allgayer, H.
The human receptor tyrosine kinase Axl gene - promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylation
Biosci. Rep.
28
161-176
2008
Drosophila sp. (in: flies), Homo sapiens (P30530), Homo sapiens
Hong, C.C.; Lay, J.D.; Huang, J.S.; Cheng, A.L.; Tang, J.L.; Lin, M.T.; Lai, G.M.; Chuang, S.E.
Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia
Cancer Lett.
268
314-324
2008
Homo sapiens
Boulay, A.; Breuleux, M.; Stephan, C.; Fux, C.; Brisken, C.; Fiche, M.; Wartmann, M.; Stumm, M.; Lane, H.A.; Hynes, N.E.
The Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast cancer
Cancer Res.
68
3743-3751
2008
Homo sapiens
Matsumura, I.; Mizuki, M.; Kanakura, Y.
Roles for deregulated receptor tyrosine kinases and their downstream signaling molecules in hematologic malignancies
Cancer Sci.
99
479-485
2008
Homo sapiens, Mus musculus, Canis lupus familiaris (O97799)
Zhang, D.Y.; Wang, Y.; Lau, C.P.; Tse, H.F.; Li, G.R.
Both EGFR kinase and Src-related tyrosine kinases regulate human ether-a-go-go-related gene potassium channels
Cell. Signal.
20
1815-1821
2008
Homo sapiens
Koch, S.; Jacobi, A.; Ryser, M.; Ehninger, G.; Thiede, C.
Abnormal localization and accumulation of FLT3-ITD, a mutant receptor tyrosine kinase involved in leukemogenesis
Cells Tissues Organs
188
225-235
2008
Homo sapiens
Baskar, S.; Kwong, K.Y.; Hofer, T.; Levy, J.M.; Kennedy, M.G.; Lee, E.; Staudt, L.M.; Wilson, W.H.; Wiestner, A.; Rader, C.
Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia
Clin. Cancer Res.
14
396-404
2008
Homo sapiens (Q01973), Homo sapiens
MacLeod, H.; Bhasin, N.; Wetzler, L.M.
Role of protein tyrosine kinase and Erk1/2 activities in the Toll-like receptor 2-induced cellular activation of murine B cells by neisserial porin
Clin. Vaccine Immunol.
15
630-637
2008
Mus musculus
Caldwell, C.C.; Martignoni, A.; Leonis, M.A.; Ondiveeran, H.K.; Fox-Robichaud, A.E.; Waltz, S.E.
Ron receptor tyrosine kinase-dependent hepatic neutrophil recruitment and survival benefit in a murine model of bacterial peritonitis
Crit. Care Med.
36
1585-1593
2008
Mus musculus (Q62190), Mus musculus
Delalande, J.M.; Barlow, A.J.; Thomas, A.J.; Wallace, A.S.; Thapar, N.; Erickson, C.A.; Burns, A.J.
The receptor tyrosine kinase RET regulates hindgut colonization by sacral neural crest cells
Dev. Biol.
313
279-292
2008
Gallus gallus, Homo sapiens
Schulte, J.H.; Kuhfittig-Kulle, S.; Klein-Hitpass, L.; Schramm, A.; Biard, D.S.; Pfeiffer, P.; Eggert, A.
Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells
DNA Repair
7
1757-1764
2008
Rattus norvegicus (P35739), Homo sapiens (Q16288), Homo sapiens
Lueth, A.; Loewe, W.
Syntheses of 4-(indole-3-yl)quinazolines: a new class of epidermal growth factor receptor tyrosine kinase inhibitors
Eur. J. Med. Chem.
43
1478-1488
2008
Homo sapiens
Sritana, N.; Auewarakul, C.U.
KIT and FLT3 receptor tyrosine kinase mutations in acute myeloid leukemia with favorable cytogenetics: Two novel mutations and selective occurrence in leukemia subtypes and age groups
Exp. Mol. Pathol.
85
227-231
2008
Homo sapiens
Wong, C.I.; Yap, H.L.; Lim, S.G.; Guo, J.Y.; Goh, B.C.; Lee, S.C.
Lack of somatic ErbB2 tyrosine kinase domain mutations in hepatocellular carcinoma
Hepatol. Res.
38
838-841
2008
Homo sapiens
Daneshmanesh, A.H.; Mikaelsson, E.; Jeddi-Tehrani, M.; Bayat, A.A.; Ghods, R.; Ostadkarampour, M.; Akhondi, M.; Lagercrantz, S.; Larsson, C.; Osterborg, A.; Shokri, F.; Mellstedt, H.; Rabbani, H.
Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy
Int. J. Cancer
123
1190-1195
2008
Homo sapiens (Q01973), Homo sapiens
Ueno, Y.; Sakurai, H.; Tsunoda, S.; Choo, M.K.; Matsuo, M.; Koizumi, K.; Saiki, I.
Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells
Int. J. Cancer
123
340-347
2008
Mus musculus (Q01279), Mus musculus (Q61526)
Abdulhussein, R.; Koo, D.H.; Vogel, W.F.
Identification of disulfide-linked dimers of the receptor tyrosine kinase DDR1
J. Biol. Chem.
283
12026-12033
2008
Homo sapiens (Q08345), Homo sapiens
Nomachi, A.; Nishita, M.; Inaba, D.; Enomoto, M.; Hamasaki, M.; Minami, Y.
Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A
J. Biol. Chem.
283
27973-27981
2008
Mus musculus, Homo sapiens (Q01974)
Bocharov, E.V.; Mayzel, M.L.; Volynsky, P.E.; Goncharuk, M.V.; Ermolyuk, Y.S.; Schulga, A.A.; Artemenko, E.O.; Efremov, R.G.; Arseniev, A.S.
Spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1
J. Biol. Chem.
283
29385-29395
2008
Homo sapiens
Sangwan, V.; Paliouras, G.N.; Abella, J.V.; Dube, N.; Monast, A.; Tremblay, M.L.; Park, M.
Regulation of the Met receptor tyrosine kinase by the protein tyrosine phosphatases PTP1B and TCPTP
J. Biol. Chem.
283
34374-34383
2008
Homo sapiens, Mus musculus
Vazquez-Martin, A.; Ortega-Delgado, F.J.; Fernandez-Real, J.M.; Menendez, J.A.
The tyrosine kinase receptor HER2 (erbB-2): From oncogenesis to adipogenesis
J. Cell. Biochem.
105
1147-1152
2008
Mus musculus (P70424)
Nevo, O.; Many, A.; Xu, J.; Kingdom, J.; Piccoli, E.; Zamudio, S.; Post, M.; Bocking, A.; Todros, T.; Caniggia, I.
Placental expression of soluble fms-like tyrosine kinase 1 is increased in singletons and twin pregnancies with intrauterine growth restriction
J. Clin. Endocrinol. Metab.
93
285-292
2008
Homo sapiens
Liu, Z.; Hou, P.; Ji, M.; Guan, H.; Studeman, K.; Jensen, K.; Vasko, V.; El-Naggar, A.K.; Xing, M.
Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers
J. Clin. Endocrinol. Metab.
93
3106-3116
2008
Homo sapiens
Brantley-Sieders, D.M.; Zhuang, G.; Hicks, D.; Fang, W.B.; Hwang, Y.; Cates, J.M.; Coffman, K.; Jackson, D.; Bruckheimer, E.; Muraoka-Cook, R.S.; Chen, J.
The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling
J. Clin. Invest.
118
64-78
2008
Homo sapiens (P29317), Homo sapiens, Mus musculus (Q03145), Mus musculus
Klatt, A.; Zhang, Z.; Kalantari, P.; Hankey, P.A.; Gilmour, D.S.; Henderson, A.J.
The receptor tyrosine kinase RON represses HIV-1 transcription by targeting RNA polymerase II processivity
J. Immunol.
180
1670-1677
2008
Homo sapiens
Wilson, C.B.; Ray, M.; Lutz, M.; Sharda, D.; Xu, J.; Hankey, P.A.
The RON receptor tyrosine kinase regulates IFN-gamma production and responses in innate immunity
J. Immunol.
181
2303-2310
2008
Mus musculus (Q62190)
Todt, J.C.; Hu, B.; Curtis, J.L.
The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages
J. Leukoc. Biol.
84
510-518
2008
Mus musculus (Q60805), Mus musculus
Harmange, J.C.; Weiss, M.M.; Germain, J.; Polverino, A.J.; Borg, G.; Bready, J.; Chen, D.; Choquette, D.; Coxon, A.; DeMelfi, T.; DiPietro, L.; Doerr, N.; Estrada, J.; Flynn, J.; Graceffa, R.F.; Harriman, S.P.; Kaufman, S.; La, D.S.; Long, A.; Martin, M.W.; Neervannan, S.; Patel, V.F.; Potashman, M.; Regal, K.
Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation
J. Med. Chem.
51
1649-1667
2008
Rattus norvegicus (O08775), Mus musculus (P35918), Homo sapiens (P35968), Homo sapiens
Weiss, M.M.; Harmange, J.C.; Polverino, A.J.; Bauer, D.; Berry, L.; Berry, V.; Borg, G.; Bready, J.; Chen, D.; Choquette, D.; Coxon, A.; DeMelfi, T.; Doerr, N.; Estrada, J.; Flynn, J.; Graceffa, R.F.; Harriman, S.P.; Kaufman, S.; La, D.S.; Long, A.; Neervannan, S.; Patel, V.F.; Potashman, M.; Regal, K.; Rove, R.o.v.e.t.
Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors
J. Med. Chem.
51
1668-1680
2008
Homo sapiens (P35968)
Hu, E.; Tasker, A.; White, R.D.; Kunz, R.K.; Human, J.; Chen, N.; Buerli, R.; Hungate, R.; Novak, P.; Itano, A.; Zhang, X.; Yu, V.; Nguyen, Y.; Tudor, Y.; Plant, M.; Flynn, S.; Xu, Y.; Meagher, K.L.; Whittington, D.A.; Ng, G.Y.
Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit
J. Med. Chem.
51
3065-3068
2008
Homo sapiens (P35968), Mus musculus (P05532), Mus musculus C57BL/6 (P05532)
Romanelli, R.J.; Wood, T.L.
Directing traffic in neural cells: determinants of receptor tyrosine kinase localization and cellular responses
J. Neurochem.
105
2055-2068
2008
Cricetulus griseus, Homo sapiens, Rattus norvegicus (P35739)
Zhu, D.; Yang, Z.; Luo, Z.; Luo, S.; Xiong, W.C.; Mei, L.
Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin
J. Neurosci.
28
1688-1696
2008
Mus musculus (Q61006)
Milner, C.S.; Hansen, T.M.; Singh, H.; Brindle, N.P.
Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis
Microvasc. Res.
77
187-191
2009
Homo sapiens (P35590), Homo sapiens (Q02763), Homo sapiens
Wilhelm, S.M.; Adnane, L.; Newell, P.; Villanueva, A.; Llovet, J.M.; Lynch, M.
Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
Mol. Cancer Ther.
7
3129-3140
2008
Homo sapiens, Mus musculus
Takagi, K.; Okuda-Ashitaka, E.; Mabuchi, T.; Katano, T.; Ohnishi, T.; Matsumura, S.; Ohnaka, M.; Kaneko, S.; Abe, T.; Hirata, T.; Fujiwara, S.; Minami, T.; Ito, S.
Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation
Neuroscience
153
1278-1288
2008
Mus musculus
Ischenko, I.; Camaj, P.; Seeliger, H.; Kleespies, A.; Guba, M.; De Toni, E.N.; Schwarz, B.; Graeb, C.; Eichhorn, M.E.; Jauch, K.W.; Bruns, C.J.
Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling
Oncogene
27
7212-722
2008
Homo sapiens
Feres, K.J.; Ischenko, I.; Hayman, M.J.
The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells
Oncogene
28
279-288
2008
Homo sapiens
Toth, J.; Egervari, K.; Klekner, A.; Bognar, L.; Szanto, J.; Nemes, Z.; Szollosi, Z.
Analysis of EGFR gene amplification, protein over-expression and tyrosine kinase domain mutation in recurrent glioblastoma
Pathol. Oncol. Res.
15
225-229
2009
Homo sapiens
Krishnamoorthy, S.
Receptor tyrosine kinase (RTK) mediated tyrosine phosphor-proteome from Drosophila S2 (ErbB1) cells reveals novel signaling networks
PLoS ONE
3
e2877
2008
Drosophila melanogaster (P09208), Homo sapiens (P35916), Homo sapiens
Kong, A.; Calleja, V.; Leboucher, P.; Harris, A.; Parker, P.J.; Larijani, B.
HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells
PLoS ONE
3
e2881
2008
Homo sapiens (P00533), Homo sapiens (P04626), Homo sapiens (P21860), Homo sapiens
Nurmio, M.; Kallio, J.; Toppari, J.; Jahnukainen, K.
Adult reproductive functions after early postnatal inhibition by imatinib of the two receptor tyrosine kinases, c-kit and PDGFR, in the rat testis
Reprod. Toxicol.
25
442-446
2008
Rattus norvegicus
Chen, X.S.; Nie, X.Q.; Chen, C.M.; Wu, J.Y.; Wu, J.; Lu, J.S.; Shao, Z.M.; Shen, Z.Z.; Shen, K.W.
Weekly paclitaxel plus carboplatin is an effective nonanthracycline-containing regimen as neoadjuvant chemotherapy for breast cancer
Ann. Oncol.
21
961-967
2010
Homo sapiens
El-Sahwi, K.; Bellone, S.; Cocco, E.; Cargnelutti, M.; Casagrande, F.; Bellone, M.; Abu-Khalaf, M.; Buza, N.; Tavassoli, F.A.; Hui, P.; Silasi, D.A.; Azodi, M.; Schwartz, P.E.; Rutherford, T.J.; Pecorelli, S.; Santin, A.D.
In vitro activity of pertuzumab in combination with trastuzumab in uterine serous papillary adenocarcinoma
Br. J. Cancer
102
134-143
2010
Homo sapiens
Bachran, C.; Weng, A.; Bachran, D.; Riese, S.B.; Schellmann, N.; Melzig, M.F.; Fuchs, H.
The distribution of saponins in vivo affects their synergy with chimeric toxins against tumours expressing human epidermal growth factor receptors in mice
Br. J. Pharmacol.
159
345-352
2010
Homo sapiens
Becher, O.J.; Hambardzumyan, D.; Walker, T.R.; Helmy, K.; Nazarian, J.; Albrecht, S.; Hiner, R.L.; Gall, S.; Huse, J.T.; Jabado, N.; MacDonald, T.J.; Holland, E.C.
Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma
Cancer Res.
70
2548-2557
2010
Homo sapiens
Baldus, S.E.; Schaefer, K.L.; Engers, R.; Hartleb, D.; Stoecklein, N.H.; Gabbert, H.E.
Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases
Clin. Cancer Res.
16
790-799
2010
Homo sapiens
Diogenes, M.E.; Bezerra, F.F.; Cabello, G.M.; Cabello, P.H.; Mendonca, L.M.; Oliveira Junior, A.V.; Donangelo, C.M.
Vitamin D receptor gene FokI polymorphisms influence bone mass in adolescent football (soccer) players
Eur. J. Appl. Physiol.
108
31-38
2010
Homo sapiens
Arisaka, M.; Nakamura, T.; Yamada, A.; Negishi, Y.; Aramaki, Y.
Involvement of protein kinase Cdelta in induction of apoptosis by cationic liposomes in macrophage-like RAW264.7 cells
FEBS Lett.
584
1016-1020
2010
Mus musculus
David, A.; Rose, S.J.; Miraki-Moud, F.; Metherell, L.A.; Savage, M.O.; Clark, A.J.; Camacho-Huebner, C.
Acid-labile subunit deficiency and growth failure: description of two novel cases
Horm. Res. Paediatr.
73
328-334
2010
Homo sapiens
Bando, M.; Hiroshima, Y.; Kataoka, M.; Herzberg, M.C.; Ross, K.F.; Shinohara, Y.; Yamamoto, T.; Nagata, T.; Kido, J.
Modulation of calprotectin in human keratinocytes by keratinocyte growth factor and interleukin-1alpha
Immunol. Cell Biol.
88
328-333
2010
Homo sapiens
Abraham, D.; Zins, K.; Sioud, M.; Lucas, T.; Schaefer, R.; Stanley, E.R.; Aharinejad, S.
Stromal cell-derived CSF-1 blockade prolongs xenograft survival of CSF-1-negative neuroblastoma
Int. J. Cancer
126
1339-1352
2010
Homo sapiens
Deng, M.; Huang, H.; Jin, H.; Dirsch, O.; Dahmen, U.
The anti-proliferative side effects of AEE788, a tyrosine kinase inhibitor blocking both EGF- and VEGF-receptor, are liver-size-dependent after partial hepatectomy in rats
Invest. New Drugs
29
593-606
2011
Rattus norvegicus
Buttar, N.S.; DeMars, C.J.; Lomberk, G.; Rizvi, S.; Bonilla-Velez, J.; Achra, S.; Rashtak, S.; Wang, K.K.; Fernandez-Zapico, M.E.; Urrutia, R.
Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis
J. Biol. Chem.
285
11433-11444
2010
Homo sapiens
Doyle, S.; Pyndiah, S.; De Gois, S.; Erickson, J.D.
Excitation-transcription coupling via calcium/calmodulin-dependent protein kinase/ERK1/2 signaling mediates the coordinate induction of VGLUT2 and Narp triggered by a prolonged increase in glutamatergic synaptic activity
J. Biol. Chem.
285
14366-14376
2010
Rattus norvegicus
Alberobello, A.T.; DEsposito, V.; Marasco, D.; Doti, N.; Ruvo, M.; Bianco, R.; Tortora, G.; Esposito, I.; Fiory, F.; Miele, C.; Beguinot, F.; Formisano, P.
Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death
J. Biol. Chem.
285
6563-6572
2010
Homo sapiens
Alex, D.; Leong, E.C.; Zhang, Z.J.; Yan, G.T.; Cheng, S.H.; Leong, C.W.; Li, Z.H.; Lam, K.H.; Chan, S.W.; Lee, S.M.
Resveratrol derivative, trans-3,5,4-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation
J. Cell. Biochem.
109
339-346
2010
Danio rerio
Ben Ammar, A.; Petit, F.; Alexandri, N.; Gaudon, K.; Bauche, S.; Rouche, A.; Gras, D.; Fournier, E.; Koenig, J.; Stojkovic, T.; Lacour, A.; Petiot, P.; Zagnoli, F.; Viollet, L.; Pellegrini, N.; Orlikowski, D.; Lazaro, L.; Ferrer, X.; Stoltenburg, G.; Paturneau-Jouas, M.; Hentati, F.; Fardeau, M.; Sternberg, D.; Hantai, D.; Richard, P.; Eymard, B.
Phenotype genotype analysis in 15 patients presenting a congenital myasthenic syndrome due to mutations in DOK7
J. Neurol.
257
754-766
2010
Homo sapiens
Baudhuin, M.; Renault, R.; Charrier, C.; Riet, A.; Moreau, A.; Brion, R.; Gouin, F.; Duplomb, L.; Heymann, D.
Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis
J. Pathol.
221
77-86
2010
Homo sapiens
Chen, Y.; Lu, N.; Ling, Y.; Wang, L.; You, Q.; Li, Z.; Guo, Q.
LYG-202, a newly synthesized flavonoid, exhibits potent anti-angiogenic activity in vitro and in vivo
J. Pharmacol. Sci.
112
37-45
2010
Homo sapiens
Cunningham, D.L.; Sweet, S.M.; Cooper, H.J.; Heath, J.K.
Differential phosphoproteomics of fibroblast growth factor signaling: identification of Src family kinase-mediated phosphorylation events
J. Proteome Res.
9
2317-2328
2010
Mus musculus
Carrillo-Garcia, C.; Suh, Y.; Obernier, K.; Mandl, G.H.; Ciccolini, F.
Multipotent precursors in the anterior and hippocampal subventricular zone display similar transcription factor signatures but their proliferation and maintenance are differentially regulated
Mol. Cell. Neurosci.
44
318-329
2010
Mus musculus
Ferguson, E.L.; Richardson, S.C.; Duncan, R.
Studies on the mechanism of action of dextrin-phospholipase A2 and its suitability for use in combination therapy
Mol. Pharm.
7
510-521
2010
Homo sapiens
Bukowski, R.M.; Yasothan, U.; Kirkpatrick, P.
Pazopanib
Nat. Rev. Drug Discov.
9
17-18
2010
Homo sapiens
Amos, P.J.; Kapur, S.K.; Stapor, P.C.; Shang, H.; Bekiranov, S.; Khurgel, M.; Rodeheaver, G.T.; Peirce, S.M.; Katz, A.J.
Human adipose-derived stromal cells accelerate diabetic wound healing: impact of cell formulation and delivery
Tissue Eng. Part A
16
1595-1606
2010
Rattus norvegicus
Bennasroune, A.; Mazot, P.; Boutterin, M.; Vigny, M.
Activation of the orphan receptor tyrosine kinase ALK by zinc
Biochem. Biophys. Res. Commun.
398
702-706
2010
Homo sapiens
Fukushima, T.; Arai, T.; Ariga-Nedachi, M.; Okajima, H.; Ooi, Y.; Iijima, Y.; Sone, M.; Cho, Y.; Ando, Y.; Kasahara, K.; Ozoe, A.; Yoshihara, H.; Chida, K.; Okada, S.; Kopchick, J.; Asano, T.; Hakuno, F.; Takahashi, S.
Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases
Biochem. Biophys. Res. Commun.
404
767-773
2011
Mus musculus, Rattus norvegicus
He, L.; Shobnam, N.; Hristova, K.
Specific inhibition of a pathogenic receptor tyrosine kinase by its transmembrane domain
Biochim. Biophys. Acta
1808
253-259
2011
Rattus norvegicus (P06494), Homo sapiens (P22607)
Gangjee, A.; Namjoshi, O.; Ihnat, M.; Buchanan, A.
The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines
Bioorg. Med. Chem. Lett.
20
3177-3181
2010
Homo sapiens (P00533), Homo sapiens (P09619), Homo sapiens (P17948), Homo sapiens (P35968)
Ducray, R.; Jones, C.; Jung, F.; Simpson, I.; Curwen, J.; Pass, M.
Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: Optimization of the aniline
Bioorg. Med. Chem. Lett.
21
4702-4704
2011
Homo sapiens
Allen, J.; Bardelle, C.; Blades, K.; Buttar, D.; Chapman, L.; Colclough, N.; Dossetter, A.; Garner, A.; Girdwood, A.; Lambert, C.; Leach, A.; Law, B.; Major, J.; Plant, H.; Slater, A.
The discovery of benzanilides as c-Met receptor tyrosine kinase inhibitors by a directed screening approach
Bioorg. Med. Chem. Lett.
21
5224-5229
2011
Homo sapiens (P08581)
Chin, Y.; Kong, J.; Han, S.
Flavonoids as receptor tyrosine kinase FLT3 inhibitors
Bioorg. Med. Chem. Lett.
23
1768-1770
2013
Homo sapiens (P36888), Homo sapiens
Khanwelkar, R.; Chen, G.; Wang, H.; Yu, C.; Huang, C.; Lee, O.; Chen, C.; Hwang, C.; Ko, C.; Chou, N.; Lin, M.; Wang, L.; Chen, Y.; Hseu, T.; Chang, C.; Hsu, H.; Lin, H.; Shih, Y.; Chou, S.; Tseng, H.; Liu, C.; Tu, C.; Hu, T.; Tsai, Y.; Chern, J.
Synthesis and structure-activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors
Bioorg. Med. Chem.
18
4674-4686
2010
Homo sapiens (P16234)
Gangjee, A.; Zaware, N.; Raghavan, S.; Yang, J.; Thorpe, J.; Ihnat, M.
N4-(3-bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: Design, synthesis, and in vivo evaluation
Bioorg. Med. Chem.
20
2444-2454
2012
Homo sapiens (P09619), Homo sapiens (P35968)
Gangjee, A.; Kurup, S.; Ihnat, M.; Thorpe, J.; Disch, B.
N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2, 4-diamines as receptor tyrosine kinase inhibitors
Bioorg. Med. Chem.
20
910-914
2012
Homo sapiens (P17948), Homo sapiens (P35968)
Gangjee, A.; Namjoshi, O.; Yu, J.; Ihnat, M.; Thorpe, J.; Bailey-Downs, L.
N2-Trimethylacetyl substituted and unsubstituted-N 4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d] pyrimidine-2,4-diamines: Design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetasta
Bioorg. Med. Chem.
21
1312-1323
2013
Homo sapiens (P00533), Homo sapiens (P17948), Homo sapiens (P35968)
Gajadhar, A.; Guha, A.
A proximity ligation assay using transiently transfected, epitope-tagged proteins: Application for in situ detection of dimerized receptor tyrosine kinases
Biotechniques
48
145-152
2010
Homo sapiens (P00533), Homo sapiens
Huang, C.; Tsai, M.; Chang, T.; Tang, W.; Chen, S.; Lai, H.; Lin, T.; Yang, J.; Yang, P.; Shih, J.; Lin, S.
ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors
Cancer Lett.
328
144-151
2013
Homo sapiens
Kim, W.; Prudkin, L.; Feng, L.; Kim, E.; Hennessy, B.; Lee, J.; Lee, J.; Glisson, B.; Lippman, S.; Wistuba, I.; Hong, W.; Lee, H.
Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors
Cancer
118
3993-4003
2012
Homo sapiens (P08069), Homo sapiens
Singla, N.; Erdjument-Bromage, H.; Himanen, J.; Muir, T.; Nikolov, D.
A semisynthetic Eph receptor tyrosine kinase provides insight into ligand-induced kinase activation
Chem. Biol.
18
361-371
2011
Homo sapiens (P54764)
Abou-Seri, S.M.
Synthesis and biological evaluation of novel 2,4-bis substituted diphenylamines as anticancer agents and potential epidermal growth factor receptor tyrosine kinase inhibitors
Eur. J. Med. Chem.
45
4113-4121
2010
Homo sapiens (P00533), Homo sapiens
Chapelat, J.; Berst, F.; Marzinzik, A.L.; Moebitz, H.; Drueckes, P.; Trappe, J.; Fabbro, D.; Seebach, D.
The substrate-activity-screening methodology applied to receptor tyrosine kinases: a proof-of-concept study
Eur. J. Med. Chem.
57
1-9
2012
Homo sapiens (P08069)
Bai, L.; Yang, J.; Ok, J.; MacK, P.; Kung, H.; Evans, C.
Simultaneous targeting of Src kinase and receptor tyrosine kinase results in synergistic inhibition of renal cell carcinoma proliferation and migration
Int. J. Cancer
130
2693-2702
2012
Homo sapiens
Kim, H.; Hwang, S.; Aaronson, S.; Mandinova, A.; Lee, S.
DDR1 receptor tyrosine kinase promotes prosurvival pathway through Notch1 activation
J. Biol. Chem.
286
17672-17681
2011
Homo sapiens (Q08345), Homo sapiens
Almudi, I.; Corominas, M.; Serras, F.
Competition between SOCS36E and Drk modulates Sevenless receptor tyrosine kinase activity
J. Cell Sci.
123
3857-3862
2010
Drosophila melanogaster
Nagano, K.; Akpan, A.; Warnasuriya, G.; Corless, S.; Totty, N.; Yang, A.; Stein, R.; Zvelebil, M.; Stensballe, A.; Burlingame, A.; Waterfield, M.; Cramer, R.; Timms, J.; Naaby-Hansen, S.
Functional proteomic analysis of long-term growth factor stimulation and receptor tyrosine kinase coactivation in Swiss 3T3 fibroblasts
Mol. Cell. Proteomics
11
1690-1708
2012
Homo sapiens
Kentsis, A.; Reed, C.; Rice, K.; Sanda, T.; Rodig, S.; Tholouli, E.; Christie, A.; Valk, P.; Delwel, R.; Ngo, V.; Kutok, J.; Dahlberg, S.; Moreau, L.; Byers, R.; Christensen, J.; Woude, G.; Licht, J.; Kung, A.; Staudt, L.; Thomas Look, A.
Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia
Nat. Med.
18
1118-1122
2012
Homo sapiens (P08581), Homo sapiens
Krejci, P.; Aklian, A.; Kaucka, M.; Sevcikova, E.; Prochazkova, J.; Masek, J.K.; Mikolka, P.; Pospisilova, T.; Spoustova, T.; Weis, M.; Paznekas, W.A.; Wolf, J.H.; Gutkind, J.S.; Wilcox, W.R.; Kozubik, A.; Jabs, E.W.; Bryja, V.; Salazar, L.; Vesela, I.; Balek, L.
Receptor tyrosine kinases activate canonical WNT/?-catenin signaling via MAP kinase/LRP6 pathway and direct beta-catenin phosphorylation
PLoS ONE
7
e35826
2012
Homo sapiens
Chao, K.L.; Tsai, I.W.; Chen, C.; Herzberg, O.
Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase
PLoS ONE
7
e41912
2012
Homo sapiens (Q04912), Homo sapiens
Moritz, A.; Li, Y.; Guo, A.; Villen, J.; Wang, Y.; MacNeill, J.; Kornhauser, J.; Sprott, K.; Zhou, J.; Possemato, A.; Ren, J.M.; Hornbeck, P.; Cantley, L.C.; Gygi, S.P.; Rush, J.; Comb, M.J.
Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases
Sci. Signal.
3
ra64
2010
Homo sapiens
Solowiej, J.; Chen, J.; Zou, H.; Grant, S.; Murray, B.
Substrate-specific conformational regulation of the receptor tyrosine kinase VEGFR2 catalytic domain
ACS Chem. Biol.
8
978-986
2013
Homo sapiens
Chavent, M.; Chetwynd, A.; Stansfeld, P.; Sansom, M.
Dimerization of the EphA1 receptor tyrosine kinase transmembrane domain: Insights into the mechanism of receptor activation
Biochemistry
53
6641-6652
2014
Homo sapiens (P21709)
Wang, X.
Structural studies of GDNF family ligands with their receptors - Insights into ligand recognition and activation of receptor tyrosine kinase RET
Biochim. Biophys. Acta
1834
2205-2212
2013
Homo sapiens
-
Takahashi, Y.; Kubota, T.; Yamamoto, S.; Kobayashi, J.
Inhibitory effects of metachromins L-Q and its related analogs against receptor tyrosine kinases EGFR and HER2
Bioorg. Med. Chem. Lett.
23
117-118
2013
Homo sapiens
Ding, L.; Tang, F.; Huang, W.; Jin, Q.; Shen, H.; Wei, P.
Design, synthesis, and biological evaluation of novel 3-pyrrolo[b] cyclohexylene-2-dihydroindolinone derivatives as potent receptor tyrosine kinase inhibitors
Bioorg. Med. Chem. Lett.
23
5630-5633
2013
Homo sapiens
Lim, C.; Oh, K.; Ha, J.; Lee, J.; Seo, H.; Chae, C.; Kim, D.; Lee, M.; Lee, B.
4-Substituted quinazoline derivatives as novel EphA2 receptor tyrosine kinase inhibitors
Bioorg. Med. Chem. Lett.
24
4080-4083
2014
Homo sapiens
Raeppel, F.; Raeppel, S.; Therrien, E.
Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004
Bioorg. Med. Chem. Lett.
25
3810-3815
2015
Homo sapiens
Hanan, E.; Baumgardner, M.; Bryan, M.; Chen, Y.; Eigenbrot, C.; Fan, P.; Gu, X.; La, H.; Malek, S.; Purkey, H.; Schaefer, G.; Schmidt, S.; Sideris, S.; Yen, I.; Yu, C.; Heffron, T.
4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase
Bioorg. Med. Chem. Lett.
26
534-539
2016
Homo sapiens
Canfield, K.; Li, J.; Wilkins, O.; Morrison, M.; Ung, M.; Wells, W.; Williams, C.; Liby, K.; Vullhorst, D.; Buonanno, A.; Hu, H.; Schiff, R.; Cook, R.; Kurokawa, M.
Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells
Cell Cycle
14
648-655
2015
Homo sapiens
Kim, K.; Choi, E.; Lee, C.
Axl receptor tyrosine kinase is a novel target of apigenin for the inhibition of cell proliferation
Int. J. Mol. Med.
34
592-598
2014
Homo sapiens
Kung, A.; Chen, Y.; Schimpl, M.; Ni, F.; Zhu, J.; Turner, M.; Molina, H.; Overman, R.; Zhang, C.
Development of specific, irreversible inhibitors for a receptor tyrosine kinase EphB3
J. Am. Chem. Soc.
138
10554-10560
2016
Homo sapiens (P54753), Homo sapiens
Sharonov, G.; Bocharov, E.; Kolosov, P.; Astapova, M.; Arseniev, A.; Feofanov, A.
Point mutations in dimerization motifs of the transmembrane domain stabilize active or inactive state of the EphA2 receptor tyrosine kinase
J. Biol. Chem.
289
14955-14964
2014
Homo sapiens (P29317), Homo sapiens
Tsou, W.; Nguyen, K.; Calarese, D.; Garforth, S.; Antes, A.; Smirnov, S.; Almo, S.; Birge, R.; Kotenko, S.
Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation
J. Biol. Chem.
289
25750-25763
2014
Homo sapiens, Homo sapiens (P30530), Homo sapiens (Q06418)
Chao, K.; Gorlatova, N.; Eisenstein, E.; Herzberg, O.
Structural basis for the binding specificity of human Recepteur d'Origine Nantais (RON) receptor tyrosine kinase to macrophage-stimulating protein
J. Biol. Chem.
289
29948-29960
2014
Homo sapiens (Q04912), Homo sapiens
Miyamoto, T.; Kim, D.; Knox, J.; Johnson, E.; Mucke, L.
Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-?-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
J. Biol. Chem.
291
1719-1734
2016
Mus musculus (P54763)
Booij, T.; Klop, M.; Yan, K.; Szantai-Kis, C.; Szokol, B.; Orfi, L.; Van De Water, B.; Keri, G.; Price, L.
Development of a 3D tissue culture-based high-content screening platform that uses phenotypic profiling to discriminate selective inhibitors of receptor tyrosine kinases
J. Biomol. Screen.
21
912-922
2016
Homo sapiens
Jones, S.; Cunningham, D.; Rappoport, J.; Heath, J.
The non-receptor tyrosine kinase Ack1 regulates the fate of activated EGFR by inducing trafficking to the p62/NBR1 pre-autophagosome
J. Cell Sci.
127
994-1006
2014
Homo sapiens
Liu, Y.; Radhakrishnan, R.
Computational delineation of tyrosyl-substrate recognition and catalytic landscapes by the epidermal growth factor receptor tyrosine kinase domain
Mol. Biosyst.
10
1890-1904
2014
Homo sapiens (P00533)
Lee, H.; Bennett, A.
Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration
Mol. Cell. Biol.
33
1430-1441
2013
Homo sapiens
Kotani, H.; Ebi, H.; Kitai, H.; Nanjo, S.; Kita, K.; Huynh, T.; Ooi, A.; Faber, A.; Mino-Kenudson, M.; Yano, S.
Co-active receptor tyrosine kinases mitigate the effect of FGFR inhibitors in FGFR1-amplified lung cancers with low FGFR1 protein expression
Oncogene
35
3587-3597
2016
Homo sapiens
Sartages, M.; Floridia, E.; Garca-Colomer, M.; Iglesias, C.; Maca, M.; Penas, P.; Couraud, P.; Romero, I.; Weksler, B.; Pombo, C.; Zalvide, J.
High levels of receptor tyrosine kinases in ccm3-deficient cells increase their susceptibility to tyrosine kinase inhibition
Biomedicines
8
1-16
2020
Homo sapiens
Li, Y.; Wang, P.; Chen, C.; Ye, T.; Han, Y.; Hou, Y.; Liu, Y.; Gong, P.; Qin, M.; Zhao, Y.
Discovery and rational design of 2-aminopyrimidine-based derivatives targeting Janus kinase 2 (JAK2) and FMS-like tyrosine kinase 3 (FLT3)
Bioorg. Chem.
104
104361
2020
Homo sapiens (P36888)
Plaza-Menacho, I.; Barnouin, K.; Barry, R.; Borg, A.; Orme, M.; Chauhan, R.; Mouilleron, S.; Martinez-Torres, R.J.; Meier, P.; McDonald, N.Q.
RET functions as a dual-specificity kinase that requires allosteric inputs from juxtamembrane elements
Cell Rep.
17
3319-3332
2016
Homo sapiens (P07949)
Wintgens, J.; Wichert, S.; Popovic, L.; Rossner, M.; Wehr, M.
Monitoring activities of receptor tyrosine kinases using a universal adapter in genetically encoded split TEV assays
Cell. Mol. Life Sci.
76
1185-1199
2019
Homo sapiens
Zhen, Y.; Finkelman, F.; Shao, W.
Mechanism of Mer receptor tyrosine kinase inhibition of glomerular endothelial cell inflammation
J. Leukoc. Biol.
103
709-717
2018
Mus musculus (Q60805)
Myers, S.; Temps, C.; Houston, D.; Brunton, V.; Unciti-Broceta, A.
Development of potent inhibitors of receptor tyrosine kinases by ligand-based drug design and target-biased phenotypic screening
J. Med. Chem.
61
2104-2110
2018
Homo sapiens (P07949), Homo sapiens (P08581), Homo sapiens (P10721), Homo sapiens (P30530), Homo sapiens (P35968), Homo sapiens (P36888), Homo sapiens (Q06418), Homo sapiens (Q12866)
Talwelkar, S.; Nagaraj, A.; Devlin, J.; Hemmes, A.; Potdar, S.; Kiss, E.; Saharinen, P.; Salmenkivi, K.; Myrnp, M.; Wennerberg, K.; Verschuren, E.
Receptor tyrosine kinase signaling networks define sensitivity to ERBB inhibition and stratify KRAS-mutant lung cancers
Mol. Cancer Ther.
18
1863-1874
2019
Homo sapiens
Mphahlele, M.; Paumo, H.; Choong, Y.
Synthesis and in vitro cytotoxicity of the 4-(halogenoanilino)-6-bromoquinazolines and their 6-(4-fluorophenyl) substituted derivatives as potential inhibitors of epidermal growth factor receptor tyrosine kinase
Pharmaceuticals
10
87
2017
Homo sapiens (P00533)
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