Literature summary for 2.7.10.1 extracted from

Caldwell, C.C.; Martignoni, A.; Leonis, M.A.; Ondiveeran, H.K.; Fox-Robichaud, A.E.; Waltz, S.E.
Ron receptor tyrosine kinase-dependent hepatic neutrophil recruitment and survival benefit in a murine model of bacterial peritonitis (2008), Crit. Care Med., 36, 1585-1593.

Search for more literature for 2.7.10.1

Application

Application	Comment	Organism
medicine	intact Ron receptor protein enhances survival following cecal ligation and puncture-induced bacterial peritonitis in mice. Ron signaling negatively regulates the response to polymicrobial infection by regulating the activation and recruitment of inflammatory cells necessary for clearing a systemic bacterial burden. This effect may be regulated in part through the Ron-dependent, macrophage-mediated production of cytokines and chemokines, namely monocyte chemoattractant protein-1, interleukin-6, and macrophage inflammatory protein-2, important for neutrophil mobilization	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	mice with a targeted deletion of the Ron tyrosine kinase signaling domain (TK-/-), show a significant decrease in survival time after bacterial infection compared with controls, which is associated with a significant increase in bacterial colony-forming units in the blood and several end-organs. The increased bacterial load is associated with increased liver necrosis and serum alanine aminotransferase levels. Neutrophils from TK-/- mice exhibit decreased spontaneous oxidative burst capacity ex vivo, and a reduced level of neutrophil migration to and translocation within the liver. Loss of Ron signaling results in significantly reduced production of serum monocyte chemoattractant protein-1 and interleukin-6 levels following cecal ligation and puncture, and peritoneal macrophage isolated from TK-/- mice exhibit blunted production of monocyte chemoattractant protein-1, interleukin-6, and macrophage inflammatory protein-2 following stimulation with endotoxin ex vivo	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q62190	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
RON receptor tyrosine kinase	-	Mus musculus

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Release 2023.1 (January 2023)