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Literature summary for 2.7.10.1 extracted from
- Calcium influx induced by activation of receptor tyrosine kinases in SV40-transfected human corneal endothelial cells (2003), Exp. Eye Res., 77, 485-495.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| genistein | - |
Homo sapiens |  |
| lavendustin A | - |
Homo sapiens | |
| additional information | enzyme inhibition leads to a reduction of capacitative calcium entry CCE in SV-40 transfected endothelial cells | Homo sapiens | |
| tyrphostin 51 | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | L-type Ca2+ channel activity is induced by enzyme activity regulating the Ca2+ flux and intracellular Ca2+ concentration, capacitative Ca2+ entry measurements using a fluorescent method | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme is responsible for induction of calcium influx in corneal endothelial cells, FGF receptor tyrosine kinase activity is linked to L-type Ca2+ channel activity, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
2 enzyme forms FGFR1 and FGFR2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| corneal epithelium | immortalized SV40-transfected corneal endothelial cells | Homo sapiens | - |
| endothelial cell | immortalized SV40-transfected corneal endothelial cells | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is responsible for induction of calcium influx in corneal endothelial cells, FGF receptor tyrosine kinase activity is linked to L-type Ca2+ channel activity, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FGF receptor tyrosine kinase | - |
Homo sapiens |
| FGFR | - |
Homo sapiens |
| fibroblast growth factor receptor | - |
Homo sapiens |
| receptor tyrosine kinase | - |
Homo sapiens |
| RTK | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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