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Literature summary for 2.7.10.1 extracted from

  • Meyer, A.N.; Gastwirt, R.F.; Schlaepfer, D.D.; Donoghue, D.J.
    The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation (2004), J. Biol. Chem., 279, 28450-28457.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information FGFR2 and FGFR3 are activated by phosphorylation through non-receptor tyrosine kinase Pyk2 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type FGFR1-4, FGFR3 mutant K650E, and truncated FGFR3, as well as a myristoylated enzyme form in 293T cells, cotransfection with non-receptor tyrosine kinase Pyk2 Homo sapiens

Protein Variants

Protein Variants Comment Organism
K650E naturally occuring activating-mutation of the enzyme causing thanatophoric dysplasia Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens activating mutations of the fibroblast growth factor receptor 3 cause skeletal dysplasias including achondroplasia, and the neonatal lethal syndromes thanatophoric dysplasia types I and II, the mutations are also involved in cancer development, e.g. in multiple myeloma, bladder carcinoma, and cervical cancer ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
4 isozymes FGFR1-4
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein FGFR2 and FGFR3, but not FGFR1 and FGFR4, are activated by phosphorylation through non-receptor tyrosine kinase Pyk2 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activating mutations of the fibroblast growth factor receptor 3 cause skeletal dysplasias including achondroplasia, and the neonatal lethal syndromes thanatophoric dysplasia types I and II, the mutations are also involved in cancer development, e.g. in multiple myeloma, bladder carcinoma, and cervical cancer Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
FGFR
-
Homo sapiens
fibroblast growth factor receptor
-
Homo sapiens
More the enzyme is a member of the FGFR family Homo sapiens