Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | FGFR2 and FGFR3 are activated by phosphorylation through non-receptor tyrosine kinase Pyk2 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of wild-type FGFR1-4, FGFR3 mutant K650E, and truncated FGFR3, as well as a myristoylated enzyme form in 293T cells, cotransfection with non-receptor tyrosine kinase Pyk2 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K650E | naturally occuring activating-mutation of the enzyme causing thanatophoric dysplasia | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | activating mutations of the fibroblast growth factor receptor 3 cause skeletal dysplasias including achondroplasia, and the neonatal lethal syndromes thanatophoric dysplasia types I and II, the mutations are also involved in cancer development, e.g. in multiple myeloma, bladder carcinoma, and cervical cancer | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
4 isozymes FGFR1-4 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | FGFR2 and FGFR3, but not FGFR1 and FGFR4, are activated by phosphorylation through non-receptor tyrosine kinase Pyk2 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | activating mutations of the fibroblast growth factor receptor 3 cause skeletal dysplasias including achondroplasia, and the neonatal lethal syndromes thanatophoric dysplasia types I and II, the mutations are also involved in cancer development, e.g. in multiple myeloma, bladder carcinoma, and cervical cancer | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FGFR | - |
Homo sapiens |
fibroblast growth factor receptor | - |
Homo sapiens |
More | the enzyme is a member of the FGFR family | Homo sapiens |