Any feedback?
Literature summary for 2.7.10.1 extracted from
- Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases (2005), J. Neurochem., 93, 899-909.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | platelet-derived growth factor receptor or epidermal growth factor receptor transactivation via recombinant dopamine D2 receptor | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| tyrphostin A9 | PDGF receptor-specific | Homo sapiens |  |
| tyrphostin AG 1478 | inhibition of EGF receptor | Homo sapiens | |
| tyrphostin AG 370 | PDGF receptor-specific | Homo sapiens | |
| Wortmannin | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | platelet-derived growth factor receptor or epidermal growth factor receptor transactivation via recombinant dopamine D2 receptor is required for activation of extracellular signal-regulated kinases, i.e. ERKs | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | activation of platelet-derived growth factor receptor and epidermal growth factor receptor | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
| NS20Y cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | platelet-derived growth factor receptor or epidermal growth factor receptor transactivation via recombinant dopamine D2 receptor is required for activation of extracellular signal-regulated kinases, i.e. ERKs | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EGF receptor | - |
Homo sapiens |
| epidermal growth factor receptor | - |
Homo sapiens |
| PDGF receptor | - |
Homo sapiens |
| platelet-derived growth factor receptor | - |
Homo sapiens |
| receptor tyrosine kinase | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
