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Literature summary for 2.7.10.1 extracted from
- Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B (2003), J. Biol. Chem., 278, 739-744.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | receptor tyrosine kinases are key regulators of cellular homeostasis, regulation of enzyme signaling by protein tyrosine phosphatase-1B, defects in this regulation result in increased phosphorylation of epidermal growth factor receptor and platelet-derived growth factor which can be compensated by other signaling mechanisms, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | activation by phosphorylation, e.g. by Erk | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Mus musculus | - |
| fibroblast | embryonic primary and immortalized | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | receptor tyrosine kinases are key regulators of cellular homeostasis, regulation of enzyme signaling by protein tyrosine phosphatase-1B, defects in this regulation result in increased phosphorylation of epidermal growth factor receptor and platelet-derived growth factor which can be compensated by other signaling mechanisms, overview | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Egfr | - |
Mus musculus |
| epidermal growth factor receptor | - |
Mus musculus |
| insulin receptor | - |
Mus musculus |
| leptin receptor | - |
Mus musculus |
| PDGFR | - |
Mus musculus |
| platelet-derived growth factor receptor | - |
Mus musculus |
| receptor tyrosine kinase | - |
Mus musculus |
| RTK | - |
Mus musculus |
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Release 2023.1 (January 2023)
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