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Literature summary for 2.7.10.1 extracted from

  • Gangjee, A.; Kurup, S.; Ihnat, M.; Thorpe, J.; Disch, B.
    N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2, 4-diamines as receptor tyrosine kinase inhibitors (2012), Bioorg. Med. Chem., 20, 910-914.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
N4-(2-fluoro-4-chlorophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine shows potent inhibition of VEGFR-2 over EGFR, platelet-derived growth factor receptor-beta and VEGFR-1; shows potent inhibition of VEGFR-2 over EGFR, platelet-derived growth factor receptor-beta and VEGFR-1 Homo sapiens
N4-(4-chloro-2-fluorophenyl)-6-(1-naphthylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine shows potent inhibition of VEGFR-2 over EGFR, platelet-derived growth factor receptor-beta and VEGFR-1; shows potent inhibition of VEGFR-2 over EGFR, platelet-derived growth factor receptor-beta and VEGFR-1 Homo sapiens
N4-(4-chloro-2-fluorophenyl)-6-(2-methylbenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine potent, multiple receptor tyrosine kinase inhibitor; potent, multiple receptor tyrosine kinase inhibitor Homo sapiens
N4-(4-chlorophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine potent, multiple receptor tyrosine kinase inhibitor; potent, multiple receptor tyrosine kinase inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P17948 VEGFR-1
-
Homo sapiens P35968 VEGFR-2
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0001
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens N4-(2-fluoro-4-chlorophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.00048
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens N4-(4-chloro-2-fluorophenyl)-6-(1-naphthylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.0152
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens N4-(4-chlorophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.016
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens N4-(4-chloro-2-fluorophenyl)-6-(2-methylbenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.0298
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens N4-(4-chloro-2-fluorophenyl)-6-(2-methylbenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.0567
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens N4-(4-chlorophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.185
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens N4-(2-fluoro-4-chlorophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.2
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens N4-(4-chloro-2-fluorophenyl)-6-(1-naphthylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine