Activating Compound | Comment | Organism | Structure |
---|---|---|---|
clathrin | EGFR is internalized classicaly through clathrin-dependent endocytosis | Homo sapiens | |
Epidermal growth factor | high-doses stimulate ubiquitination and endocytosis of EGFR through caveolae in HeLa cells | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | internatlization and retrograde trafficking of TrkA is required for neuronal survial | Rattus norvegicus |
medicine | RTKs mediate diverse processes within the developing and adult brain. Trafficking of RTKs is required for the specificity and fidelity of signal transduction and consequent biological responses within neural cells. Segregation of signaling complexes and the appropriate delivery of RTKs to these complexes is highly regulated through mechanisms including receptor-sorting sequences, adaptor proteins, specific ligand-receptor interactions, and lipid raft microdomains | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutant insulin receptor, has increased binding to insulin in an acidic endosomal environment in a patient with severe insulin resistant diabetes. Receptor mutant is degraded rather than recycled to the plasma membrane | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Antibody | monoclonal antibodies for inhibition of IGF-IR alter receptor trafficking by high affinity binding, promoting receptor degradation and consequently preventing human tumor growth in vivo | Homo sapiens | |
additional information | blocking internalization of the IGF-IR results in an attenuation of ERK activation, with no affect on the activation of the PI-3K/Akt pathway | Cricetulus griseus | |
additional information | blocking internalization of the EGFR expressed in HeLa cells decreases ERK activity but also increases protein kinase C activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | nerve growth factor-mediated survival in PC12 cells is associated with surface localized TrkA via the activation of the PI-3K/Akt pathway, whereas internalized TrkA induces nerve growth factor-mediated differentiation via the ERK pathway | Rattus norvegicus | 9986 | - |
endosome | PDGFR-beta activates various signaling pathways within endosomes including PI-3K/Akt in human hepatocellular carcinoma cell line | Homo sapiens | 5768 | - |
additional information | caveolae | Homo sapiens | - |
- |
plasma membrane | eceptors are internalized within membrane ruffles independent of clathrin (macroendocytosis) | Rattus norvegicus | 5886 | - |
plasma membrane | ErbB4 localizes to lipid rafts in a ligand-dependent manner in HEK-293 cells | Homo sapiens | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | P35739 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
additional information | hepatocellular carcinoma cell line | Homo sapiens | - |
neuron | - |
Homo sapiens | - |
oligodendrocyte | - |
Homo sapiens | - |
ovary | - |
Cricetulus griseus | - |
PC-12 cell | nerve growth factor-mediated survival is associated with surface localized TrkA via the activation of the PI-3K/Akt pathway, whereas internalized TrkA induces nerve growth factor-mediated differentiation via the ERK pathway | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
Egfr | - |
Homo sapiens |
epidermal growth factor receptor | - |
Homo sapiens |
ERBB1 | - |
Homo sapiens |
ErbB4 | - |
Homo sapiens |
FGFR1 | - |
Homo sapiens |
FGFR3 | - |
Homo sapiens |
fibroblast growth factor receptor | - |
Homo sapiens |
IGF-IR | - |
Cricetulus griseus |
IGF-IR | - |
Homo sapiens |
insulin-like growth factor type I receptor | - |
Cricetulus griseus |
insulin-like growth factor type I receptor | - |
Homo sapiens |
neurotrophin tyrosine receptor kinase | - |
Homo sapiens |
neurotrophin tyrosine receptor kinase | - |
Rattus norvegicus |
p75 neurotrophin receptor | - |
Homo sapiens |
p75NTR | - |
Homo sapiens |
PDGFR-alpha | - |
Homo sapiens |
PDGFR-beta | - |
Homo sapiens |
platelet-derived growth factor receptor | - |
Homo sapiens |
receptor tyrosine kinase | - |
Cricetulus griseus |
receptor tyrosine kinase | - |
Homo sapiens |
receptor tyrosine kinase | - |
Rattus norvegicus |
RTK | - |
Cricetulus griseus |
RTK | - |
Homo sapiens |
RTK | - |
Rattus norvegicus |
TrkA | - |
Homo sapiens |
TrkA | - |
Rattus norvegicus |
trkB | - |
Homo sapiens |
TrkC | - |
Homo sapiens |