Cloned (Comment) | Organism |
---|---|
expressed in NR6 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
DELTA746-750 | the in-frame deletion mutant is active but exhibits a higher KM for ATP and a lower Ki for erlotinib relative to the wild-type receptor | Homo sapiens |
L858R | mutant is active but exhibits a higher KM for ATP and a lower Ki for erlotinib relative to the wild-type receptor | Homo sapiens |
L861Q | comparable activity to the wild-type receptor | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
erlotinib | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0011 | - |
ATP | mutant enzyme L861Q | Homo sapiens | |
0.005 | - |
ATP | wild type enzyme | Homo sapiens | |
0.0109 | - |
ATP | mutant enzyme L858R | Homo sapiens | |
0.129 | - |
ATP | deletion mutant enzyme DELTA746-750 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + poly(Glu:Tyr) | Homo sapiens | - |
ADP + poly(Glu:Tyr) phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + poly(Glu:Tyr) | - |
Homo sapiens | ADP + poly(Glu:Tyr) phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Egfr | - |
Homo sapiens |
epidermal growth factor receptor tyrosine kinase inhibitor | - |
Homo sapiens |
erlotinib | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000033 | - |
erlotinib | deletion mutant enzyme DELTA746-750 | Homo sapiens | |
0.00000625 | - |
erlotinib | mutant enzyme L858R | Homo sapiens | |
0.0000175 | - |
erlotinib | wild type enzyme | Homo sapiens | |
0.0000487 | - |
erlotinib | mutant enzyme L861Q | Homo sapiens |