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Literature summary for 2.7.10.1 extracted from

  • Wintgens, J.; Wichert, S.; Popovic, L.; Rossner, M.; Wehr, M.
    Monitoring activities of receptor tyrosine kinases using a universal adapter in genetically encoded split TEV assays (2019), Cell. Mol. Life Sci., 76, 1185-1199 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development using the split TEV recruitment assay and integrating the universal SH2(GRB2) adapter may represent a promising approach to build a technology platform to assess receptor tyrosine kinase activities in early drug discovery to finally improve compound selectivity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
receptor tyrosine kinase
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Homo sapiens
RTK
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Homo sapiens

General Information

General Information Comment Organism
physiological function receptor tyrosine kinases play key roles in various aspects of cell biology, including cell-to-cell communication, proliferation and differentiation, survival, and tissue homeostasis, and have been implicated in various diseases including cancer and neurodevelopmental disorders Homo sapiens