Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.10.1 extracted from

  • Feres, K.J.; Ischenko, I.; Hayman, M.J.
    The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells (2008), Oncogene, 28, 279-288.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
macrophage stimulating protein MSP, its only known ligand, both MSP-dependent and MSP-independent signaling by RON. RON exhibits MSP-independent tyrosine phosphorylation in MCF-10A cells. RON exhibits increased phosphorylation on Y1238/1239 and on the Y1360 docking site in the presence of exogenously added MSP. Similar levels of RON expression in NIH-3T3 cells do not lead to tyrosine phosphorylation of RON in the absence of ligand. MSP-independent tyrosine phosphorylation of RON also in HeLa cells Homo sapiens
additional information tyrosine phosphorylation of RON depends on the activity of Src family kinases Homo sapiens

Application

Application Comment Organism
medicine RON has two alternative modes of signaling that can contribute to oncogenic behavior in normal breast epithelial cells. RON-mediated proliferation requires MSP. RON-mediated cell spreading or RON-mediated evasion of cell death are MSP independent Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
MCF-10A cells transduced with a retrovirus expressing wild-type human RON Homo sapiens

Protein Variants

Protein Variants Comment Organism
K1114M kinase dead mutant of RON, which does not exhibit any tyrosine phosphorylation in HeLa cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine PP2, completely abrogates RON-mediated cell spreading both in the absence and presence of MSP Homo sapiens
LY294002 PI3K/AKT inhibitor, has no effects on RON-mediated cell spreading either with or without MSP, but completely abrogates the cell survival properties of RON and reduces MSP-induced Transwell migration by 60-80% Homo sapiens
U0126 MEK/ERK inhibitor, has no effects on RON-mediated cell spreading either with or without MSP, but completely abrogates the cell survival properties of RON and reduces MSP-induced Transwell migration by 60-80% Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-
MCF-10A cell endogenous levels of RON are low Homo sapiens
-

Synonyms

Synonyms Comment Organism
recepteur d'origine nantais
-
Homo sapiens
Ron
-
Homo sapiens
RON receptor tyrosine kinase
-
Homo sapiens