Application | Comment | Organism |
---|---|---|
analysis | large-scale proteomic approach to identify over 200 substrates of the receptor tyrosine kinases kinase family in cancer cell lines driven by the c-Met, epidermal growth factor receptor, or platelet-derived growth factor receptor alpha receptor tyrosine kinases. For a subset of proteins with RxRxxS/T sites, phosphorylation is decreased by receptor tyrosine kinase inhibitors as well as by inhibitors of the PI3K, mTOR, and MAPK pathways. Phosphorylation of the protein chaperone small glutamine-rich tetratricopeptide repeat-containing protein alpha at Ser305 is essential for PDGFRalpha stabilization and cell survival in PDGFRalpha-dependent cancer cells | Homo sapiens |
medicine | large-scale proteomic approach to identify over 200 substrates of the receptor tyrosine kinases kinase family in cancer cell lines driven by the c-Met, epidermal growth factor receptor, or platelet-derived growth factor receptor alpha receptor tyrosine kinases. For a subset of proteins with RxRxxS/T sites, phosphorylation is decreased by receptor tyrosine kinase inhibitors as well as by inhibitors of the PI3K, mTOR, and MAPK pathways. Phosphorylation of the protein chaperone small glutamine-rich tetratricopeptide repeat-containing protein alpha at Ser305 is essential for PDGFRalpha stabilization and cell survival in PDGFRalpha-dependent cancer cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
H-1703 cell | squamous cell carcinoma | Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
metabolism | phosphorylation of the protein chaperone small glutamine-rich tetratricopeptide repeat-containing protein alpha at Ser305 is essential for isoform platelet-derived growth factor receptor PDGFRalpha stabilization and cell survival in PDGFRalpha-dependent cancer cells | Homo sapiens |