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Literature summary for 2.7.10.1 extracted from

  • Moritz, A.; Li, Y.; Guo, A.; Villen, J.; Wang, Y.; MacNeill, J.; Kornhauser, J.; Sprott, K.; Zhou, J.; Possemato, A.; Ren, J.M.; Hornbeck, P.; Cantley, L.C.; Gygi, S.P.; Rush, J.; Comb, M.J.
    Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases (2010), Sci. Signal., 3, ra64.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
analysis large-scale proteomic approach to identify over 200 substrates of the receptor tyrosine kinases kinase family in cancer cell lines driven by the c-Met, epidermal growth factor receptor, or platelet-derived growth factor receptor alpha receptor tyrosine kinases. For a subset of proteins with RxRxxS/T sites, phosphorylation is decreased by receptor tyrosine kinase inhibitors as well as by inhibitors of the PI3K, mTOR, and MAPK pathways. Phosphorylation of the protein chaperone small glutamine-rich tetratricopeptide repeat-containing protein alpha at Ser305 is essential for PDGFRalpha stabilization and cell survival in PDGFRalpha-dependent cancer cells Homo sapiens
medicine large-scale proteomic approach to identify over 200 substrates of the receptor tyrosine kinases kinase family in cancer cell lines driven by the c-Met, epidermal growth factor receptor, or platelet-derived growth factor receptor alpha receptor tyrosine kinases. For a subset of proteins with RxRxxS/T sites, phosphorylation is decreased by receptor tyrosine kinase inhibitors as well as by inhibitors of the PI3K, mTOR, and MAPK pathways. Phosphorylation of the protein chaperone small glutamine-rich tetratricopeptide repeat-containing protein alpha at Ser305 is essential for PDGFRalpha stabilization and cell survival in PDGFRalpha-dependent cancer cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
H-1703 cell squamous cell carcinoma Homo sapiens
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General Information

General Information Comment Organism
metabolism phosphorylation of the protein chaperone small glutamine-rich tetratricopeptide repeat-containing protein alpha at Ser305 is essential for isoform platelet-derived growth factor receptor PDGFRalpha stabilization and cell survival in PDGFRalpha-dependent cancer cells Homo sapiens