Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.10.1 extracted from

  • Collesi, C.; Santoro, M.M.; Gaudino, G.; Comoglio, P.M.
    A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype (1996), Mol. Cell. Biol., 16, 5518-5526.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens role for the Ron receptor in progression toward malignancy ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q04912
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification mature Ron protein is a heterodimer of disulfide-linked alpha and beta chains, originated by proteolytic cleavage of a single-chain precursor of 185000 Da. Abnormal accumulation of an uncleaved single-chain protein delta-Ron of 165000 Da in gastric cancer cell line KATO-III, this molecule is encoded by a transcript differing from the full-length RON mRNA by an in-frame deletion of 49 amino acids in the beta-chain extracellular domain. The deleted transcript originates by an alternatively spliced cassette exon of 147 bp, flanked by two short introns Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
cell culture gastric cancer cell line KATO-III Homo sapiens
-
KATO-III cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information role for the Ron receptor in progression toward malignancy Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
dimer mature Ron protein is a heterodimer of disulfide-linked alpha and beta chains, originated by proteolytic cleavage of a single-chain precursor of 185000 Da Homo sapiens

Synonyms

Synonyms Comment Organism
macrophage-stimulating protein receptor
-
Homo sapiens
Ron tyrosine kinase receptor
-
Homo sapiens