Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | role for the Ron receptor in progression toward malignancy | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q04912 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | mature Ron protein is a heterodimer of disulfide-linked alpha and beta chains, originated by proteolytic cleavage of a single-chain precursor of 185000 Da. Abnormal accumulation of an uncleaved single-chain protein delta-Ron of 165000 Da in gastric cancer cell line KATO-III, this molecule is encoded by a transcript differing from the full-length RON mRNA by an in-frame deletion of 49 amino acids in the beta-chain extracellular domain. The deleted transcript originates by an alternatively spliced cassette exon of 147 bp, flanked by two short introns | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | gastric cancer cell line KATO-III | Homo sapiens | - |
KATO-III cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | role for the Ron receptor in progression toward malignancy | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | mature Ron protein is a heterodimer of disulfide-linked alpha and beta chains, originated by proteolytic cleavage of a single-chain precursor of 185000 Da | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
macrophage-stimulating protein receptor | - |
Homo sapiens |
Ron tyrosine kinase receptor | - |
Homo sapiens |