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Literature summary for 2.7.10.1 extracted from

  • Kemp, B.E.; Parker, M.W.; Hu, S.; Tiganis, T.; House, C.
    Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity (1994), Trends Biochem. Sci., 19, 440-444.
    View publication on PubMed
Search for more literature for 2.7.10.1

Activating Compound

Activating Compound Comment Organism Structure
additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia

Inhibitors

Inhibitors Comment Organism Structure
additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mammalia 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Mammalia
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein autophosphorylation, the site often depends more on structure than on primary sequence Mammalia

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Mammalia ADP + a phosphoprotein
-
 ?
additional information substrate recognition and binding structure, the enzyme depends on basic residues for substrate recognition, substrate specificity determinants in substrates Mammalia ?
-
 ?

Synonyms

Synonyms Comment Organism
insulin-receptor tyrosine kinase
-
 Mammalia

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mammalia