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Information on EC 2.7.1.20 - adenosine kinase
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2.7.1.20 adenosine kinaseIUBMB Comments
2-Aminoadenosine can also act as acceptor.
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Word Map
- 2.7.1.20
- nucleoside
- deaminase
- purine
- amp
- adenylate
- inosine
-
salvage
- hypoxanthine
- epilepsy
-
phosphoribosyltransferase
- 5'-nucleotidase
- 5-iodotubercidin
- riboside
- deoxyadenosine
- s-adenosylhomocysteine
- deoxycytidine
- aicar
-
anticonvulsant
- tubercidin
- dipyridamole
-
neuromodulator
- ehna
-
2\'-deoxycoformycin
-
ecto-5\'-nucleotidase
- ribokinase
-
erythro-9-2-hydroxy-3-nonyl
-
adenosinergic
- 6-methylmercaptopurine
-
3hadenosine
- 2-chloroadenosine
- coformycin
-
nitrobenzylthioinosine
-
epileptogenesis
-
hypoxanthine-guanine
-
transmethylation
-
adenosine-induced
- hgprt
-
kinase-deficient
- 2'-deoxyadenosine
-
adenosine-mediated
-
3.5.4.4
- deoxycoformycin
-
non-nucleoside
- analysis
-
2.4.2.8
- 9-beta-d-arabinofuranosyladenine
-
n6-cyclopentyladenosine
-
erythro-9-2-hydroxy-3-nonyladenine
-
dado
- ara-a
- medicine
- diagnostics
-
rephosphorylation
- pharmacology
The enzyme appears in viruses and cellular organisms
Synonyms
adenosine kinase, adk, ado kinase, adk-l, adk-s, rv2202c, atp:adenosine 5'-phosphotransferase, ldadk, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
adenosine kinase (phosphorylating)
-
-
-
-
ADK
Ado kinase
AdoK
AK
kinase, adenosine (phosphorylating)
-
-
-
-
MGG_06270
Rv2202c
Tb927.6.2360
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + adenosine = ADP + AMP
-
-
-
-
ATP + adenosine = ADP + AMP
catalytic mechanism, substrate and product binding involving Asp239, Glu242, Asp316, and Arg148
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ATP + adenosine = ADP + AMP
residues G62, D299, R69, and R131 are crucial for catalytic activity
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:adenosine 5'-phosphotransferase
2-Aminoadenosine can also act as acceptor.
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CAS REGISTRY NUMBER
COMMENTARY
9027-72-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 2'-amino-2',3'-dideoxyadenosine
ADP + 2'-amino-2',3'-dideoxyadenosine 5'-phosphate
-
-
-
-
?
ATP + 2,3-difluoro-3-deaza-7-isoadenosine
ADP + 2,3-difluoro-3-deaza-7-isoadenosine 5'-phosphate
ATP + 2,6-diaminopurine riboside
ADP + 2,6-diaminopurine riboside 5'-phosphate
-
-
-
-
?
ATP + 2-(4-benzylpiperazin-1-yl)adenosine
ADP + 2-(4-benzylpiperazin-1-yl)adenosine 5'-phosphate
-
3% of the activity with adenosine
-
-
?
ATP + 2-(pyrrolidin-1-yl)adenosine
ADP + 2-(pyrrolidin-1-yl)adenosine 5'-phosphate
-
53% of the activity with adenosine
-
-
?
ATP + 2-amino-carbocyclic-adenosine
?
-
35.8% of the activity with adenosine
-
-
?
ATP + 2-benzylaminoadenosine
ADP + 2-benzylaminoadenosine 5'-phosphate
-
4% of the activity with adenosine
-
-
?
ATP + 2-cyclohexylaminoadenosine
ADP + 2-cyclohexylaminoadenosine 5'-phosphate
-
3% of the activity with adenosine
-
-
?
ATP + 2-ethylaminoadenosine
ADP + 2-ethylaminoadenosine 5'-phosphate
-
3% of the activity with adenosine
-
-
?
ATP + 2-fluoro-3-deaza-adenosine
ADP + 2-fluoro-3-deaza-AMP
-
1.7% of the activity with adenosine
-
-
?
ATP + 2-fluoro-3-deazaadenosine
ADP + 2-fluoro-3-deazaadenosine 5'-phosphate
-
specific activity 63 nM/mg/min
-
-
?
ATP + 2-fluoro-9-[beta-D-arabinofuranosyl]-adenine
ADP + 2-fluoro-9-[beta-D-arabinofuranosyl]-AMP
0.9% of the activity with adenosine
-
-
?
ATP + 2-fluoro-adenosine
ADP + 2-fluoro-AMP
52% of the activity with adenosine
-
-
?
ATP + 2-isopropylamino-N6-isopropyladenosine
ADP + 2-isopropylamino-N6-isopropyladenosine 5'-phosphate
-
81% of the activity with adenosine
-
-
?
ATP + 2-isopropylaminoadenosine
ADP + 2-isopropylaminoadenosine 5'-phosphate
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4% of the activity with adenosine
-
-
?
ATP + 2-methyl-adenosine
ADP + 2-methyl-AMP
2% of the activity with adenosine
-
-
?
ATP + 3-deazaadenosine
ADP + 3-deaza-AMP
-
0.03% of the activity with adenosine
-
-
?
ATP + 3-deazaadenosine
ADP + 3-deazaadenosine 5'-phosphate
-
specific activity 1 nM/mg/min
-
-
?
ATP + 3-[beta-D-ribofuranosyl]-adenine
?
-
11.2% of the activity with adenosine
-
-
?
ATP + 3-[beta-D-ribofuranosyl]-adenine
ADP + 3-[beta-D-ribofuranosyl]-AMP
0.7% of the activity with adenosine
-
-
?
ATP + 6-bromopurine riboside
ADP + 6-bromopurine riboside 5'-phosphate
-
-
-
-
?
ATP + 6-fluoromethylpurine riboside
ADP + 6-fluoromethylpurine riboside 5'-phosphate
-
-
-
-
?
ATP + 6-methyl-purine riboside
ADP + 6-methylpurine-D-riboside 5'-phosphate
2.75% of the activity with adenosine
-
-
?
ATP + 6-methylmercaptopurine riboside
ADP + 6-methylmercaptopurine-D-riboside 5'-phosphate
ATP + 8-aza-adenosine
ADP + 8-aza-AMP
4% of the activity with adenosine
-
-
?
ATP + 8-aza-carbocyclic-adenosine
ADP + 8-aza-carbocyclic-AMP
4% of the activity with adenosine
-
-
?
ATP + 9-[alpha-L-lyxofuranosyl]-2-fluoro-adenine
ADP + 9-[alpha-L-lyxofuranosyl]-2-fluoro-AMP
3.3% of the activity with adenosine
-
-
?
ATP + 9-[alpha-L-lyxofuranosyl]-adenine
?
-
15% of the activity with adenosine
-
-
?
ATP + 9-[alpha-L-lyxofuranosyl]-adenine
ADP + 9-[alpha-L-lyxofuranosyl]-AMP
3.8% of the activity with adenosine
-
-
?
ATP + 9-[beta-D-5-methyl-(allo)-ribofuranosyl]-2-fluoro-adenine
ADP + 9-[beta-D-5-methyl-(allo)-ribofuranosyl]-2-fluoro-AMP
0.1% of the activity with adenosine
-
-
?
ATP + 9-[beta-D-arabinofuranosyl]-adenine
?
-
0.25% of the activity with adenosine
-
-
?
ATP + 9-[beta-D-arabinofuranosyl]-adenine
ADP + 9-[beta-D-arabinofuranosyl]-adenine 5'-phosphate
0.6% of the activity with adenosine
-
-
?
ATP + adenosine
?
the obligate intracellular parasite Toxoplasma gondii is incapable of synthesizing purine nucleotides de novo and relies completely on purines salvaged from the host cells. Adenosine is the preferred precursor and is phosphorylated by adenosine kinase (AK), the most active enzyme in adenosine metabolism in Toxoplasma gondii
-
-
?
ATP + arabinofuranosyladenine
ADP + arabinofuranosyladenine 5'-phosphate
-
-
-
-
?
ATP + aristeromycin
ADP + aristeromycin 5'-phosphate
37.5% of the activity with adenosine
-
-
?
ATP + N1-oxy-N6-methyladenosine
ADP + N1-oxy-N6-methyladenosine 5'-phosphate
-
-
-
-
?
ATP + N6-delta2-isopentenyl-adenosine
ADP + N6-delta2-isopentenyl-adenosine 5'-phosphate
-
-
-
-
?
ATP + N6-methyl-3'-deoxyadenosine
ADP + N6-methyl-3'-deoxyadenosine 5'-phosphate
-
-
-
-
?
ATP + xylofuranosyladenine
ADP + xylofuranosyladenine 5'-phosphate
-
-
-
-
?
dGTP + adenosine
dGDP + AMP
4.7fold higher activity compared to ATP
-
-
?
ATP + 2'-deoxy-2,2'-difluoro-adenosine
ADP + 2'-deoxy-2,2'-difluoro-AMP
0.5% of the activity with adenosine
-
-
?
ATP + 2'-deoxy-2,2'-difluoro-adenosine
ADP + 2'-deoxy-2,2'-difluoro-AMP
0.5% of the activity with adenosine
-
-
?
ATP + 2'-deoxy-adenosine
ADP + 2'-deoxy-AMP
0.3% of the activity with adenosine
-
-
?
ATP + 2'-deoxy-adenosine
ADP + 2'-deoxy-AMP
0.3% of the activity with adenosine
-
-
?
ATP + 2'-deoxy-adenosine
ADP + 2'-deoxy-AMP
-
-
-
-
?
ATP + 2,3-difluoro-3-deaza-7-iso-adenosine
ADP + 2,3-difluoro-3-deaza-7-iso-AMP
-
0.2% of the activity with adenosine
-
-
?
ATP + 2,3-difluoro-3-deaza-7-iso-adenosine
ADP + 2,3-difluoro-3-deaza-7-iso-AMP
-
0.03% of the activity with adenosine
-
-
?
ATP + 2,3-difluoro-3-deaza-7-isoadenosine
ADP + 2,3-difluoro-3-deaza-7-isoadenosine 5'-phosphate
-
specific activity: 5 nM/mg/min
-
-
?
ATP + 2,3-difluoro-3-deaza-7-isoadenosine
ADP + 2,3-difluoro-3-deaza-7-isoadenosine 5'-phosphate
-
specific activity1 1 nM/mg/min
-
-
?
ATP + 2,3-difluoro-3-deaza-adenosine
ADP + 2,3-difluoro-3-deaza-AMP
-
0.2% of the activity with adenosine
-
-
?
ATP + 2,3-difluoro-3-deaza-adenosine
ADP + 2,3-difluoro-3-deaza-AMP
-
2.2% of the activity with adenosine
-
-
?
ATP + 2,3-difluoro-3-deazaadenosine
ADP + 2,3-difluoro-3-deazaadenosine 5'-phosphate
-
specific activity: 1 nM/mg/min
-
-
?
ATP + 2,3-difluoro-3-deazaadenosine
ADP + 2,3-difluoro-3-deazaadenosine 5'-phosphate
-
specific activity 81 nM/mg/min
-
-
?
ATP + 2-amino-carbocyclic-adenosine
ADP + 2-amino-carbocyclic-AMP
0.4% of the activity with adenosine
-
-
?
ATP + 2-amino-carbocyclic-adenosine
ADP + 2-amino-carbocyclic-AMP
0.4% of the activity with adenosine
-
-
?
ATP + 2-chloro-adenosine
ADP + 2-chloro-AMP
11.5% of the activity with adenosine
-
-
?
ATP + 2-chloro-adenosine
ADP + 2-chloro-AMP
11.5% of the activity with adenosine
-
-
?
ATP + 2-chloroadenosine
ADP + 2-chloroadenosine 5'-phosphate
-
-
-
-
?
ATP + 2-fluoroadenosine
ADP + 2-fluoroadenosine 5'-phosphate
-
-
-
-
?
ATP + 2-methyladenosine
ADP + 2-methyl-AMP
activation of 2-mehyladenosine
-
-
?
ATP + 2-methyladenosine
ADP + 2-methyl-AMP
30fold lower activity compared to adenosine
-
-
?
ATP + 2-methyladenosine
ADP + 2-methyl-AMP
Mycobacterium tuberculosis H37Ra / ATCC 25177
activation of 2-mehyladenosine
-
-
?
ATP + 3'-amino-3'-deoxyadenosine
ADP + 3'-amino-3'-deoxyadenosine 5'-phosphate
-
-
-
-
?
ATP + 3'-amino-3'-deoxyadenosine
ADP + 3'-amino-3'-deoxyadenosine 5'-phosphate
-
-
-
-
?
ATP + 3-fluoro-3-deaza-adenosine
ADP + 3-fluoro-3-deaza-AMP
-
0.04% of the activity with adenosine
-
-
?
ATP + 3-fluoro-3-deaza-adenosine
ADP + 3-fluoro-3-deaza-AMP
-
0.4% of the activity with adenosine
-
-
?
ATP + 3-fluoro-3-deazaadenosine
ADP + 3-fluoro-3-deazaadenosine 5'-phosphate
-
specific activity: 1 nM/mg/min
-
-
?
ATP + 3-fluoro-3-deazaadenosine
ADP + 3-fluoro-3-deazaadenosine 5'-phosphate
-
specific activity 16 nM/mg/min
-
-
?
ATP + 6-chloropurine riboside
ADP + 6-chloropurine riboside 5'-phosphate
-
-
-
-
?
ATP + 6-chloropurine riboside
ADP + 6-chloropurine riboside 5'-phosphate
-
-
-
-
?
ATP + 6-methylmercaptopurine riboside
ADP + 6-methylmercaptopurine-D-riboside 5'-phosphate
-
-
-
-
?
ATP + 6-methylmercaptopurine riboside
ADP + 6-methylmercaptopurine-D-riboside 5'-phosphate
-
-
-
-
?
ATP + 8-aza-9-deazaadenosine
ADP + 8-aza-9-deazaadenosine 5'-phosphate
-
-
-
-
?
ATP + 8-aza-9-deazaadenosine
ADP + 8-aza-9-deazaadenosine 5'-phosphate
-
-
-
-
?
ATP + 9-[beta-D-ribofuranosyl]-purine
ADP + 9-[beta-D-ribofuranosyl]-purine 5'-phosphate
-
-
-
-
?
ATP + 9-[beta-D-ribofuranosyl]-purine
ADP + 9-[beta-D-ribofuranosyl]-purine 5'-phosphate
-
-
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is highly specific for adenosine and shows best activity with ATP as cosubstrate
-
-
?
ATP + adenosine
ADP + AMP
the enzyme catalyzes the salvage synthesis of 5'-AMP from ADP and ATP
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, housekeeping enzymes, essential for maintainance of S-adenosyl-methionine-dependent transmethylation activities, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
adenosine kinase modulates root gravitropism and cap morphogenesis
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is specific for nucleosides, it repels the entrance of phosphorylated sugars
-
?
ATP + adenosine
ADP + AMP
adenosine kinase (ADK) is the first enzyme in the adenosine remediation pathway that catalyzes adenosine phosphorylation into adenosine monophosphate, thus regulating adenosine homeostasis in cells
-
-
?
ATP + adenosine
ADP + AMP
-
key enzyme for the regulation of intracellular adenosine level
-
?