Application | Comment | Organism |
---|---|---|
analysis | the coexpression of adenosine kinase TbAK and adenosine transporter gene TbAT1 in Saccharomyces cerevisiae ado1 ade2 double mutants proves to be a convenient tool for testing nucleoside analogues for uptake and activation by Trypanosoma brucei adenosine salvage enzymes | Trypanosoma brucei |
Cloned (Comment) | Organism |
---|---|
expresion in Saccharomyces cerevisiae | Trypanosoma brucei |
expression of TbAK in Saccharomyces cerevisiae complements a null mutation in the adenosine kinase gene ado1. The concomitant expression of TbAK with the Trypanosoma brucei adenosine transporter gene TbAT1 allows Saccharomyces cerevisiae ado1 ade2 double mutants to grow on adenosine as the sole purine source and, at the same time, sensitizes them to adenosine antimetabolites | Trypanosoma brucei |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Trypanosoma brucei | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Trypanosoma brucei | the enzyme plays a role in susceptibility to adenosine antimetabolites | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bloodstream form | - |
Trypanosoma brucei | - |
procyclic form | - |
Trypanosoma brucei | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme plays a role in susceptibility to adenosine antimetabolites | Trypanosoma brucei | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TbAK | - |
Trypanosoma brucei |