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Literature summary for 2.7.1.20 extracted from

  • Park, J.; Singh, B.; Gupta, R.S.
    Inhibition of adenosine kinase by phosphonate and bisphosphonate derivatives (2006), Mol. Cell. Biochem., 283, 11-21.
    View publication on PubMed
Search for more literature for 2.7.1.20

Activating Compound

Activating Compound Comment Organism Structure
acetyl phosphate 10 mM, activity is stimulated more than 10fold Cricetulus griseus
Carbamoyl phosphate 10 mM, activity is stimulated more than 10fold Cricetulus griseus
dihydroxyacetone phosphate 10 mM, activity is stimulated more than 10fold Cricetulus griseus
Imidodiphosphate
-
 Cricetulus griseus
phosphate 10 mM, activity is stimulated more than 10fold Cricetulus griseus

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Cricetulus griseus

Inhibitors

Inhibitors Comment Organism Structure
2-carboxyethylphosphonic acid
-
 Cricetulus griseus
clodronate inhibits adenosine kinase activity in a dose-dependent manner in the presence of 10 mM phosphate Cricetulus griseus
diethylphosphonoacetic acid
-
 Cricetulus griseus
etidronate inhibits adenosine kinase activity in a dose-dependent manner in the presence of 10 mM phosphate Cricetulus griseus
methylphosphonic acid
-
 Cricetulus griseus
N-(phosphonomethyl)-glycine
-
 Cricetulus griseus
N-(phosphonomethyl)iminodiacetic acid
-
 Cricetulus griseus
Phosphonoacetic acid
-
 Cricetulus griseus

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
 recombinant
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + adenosine
-
 Cricetulus griseus ADP + AMP
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.36
-
 etidronate
-
 Cricetulus griseus
7.19
-
 clodronate
-
 Cricetulus griseus