Disease on EC 2.7.1.20 - adenosine kinase
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5'-nucleotidase deficiency
Inborn errors of purine metabolism: clinical update and therapies.
Acidosis
Involvement of adenosine in depression of synaptic transmission during hypercapnia in isolated spinal cord of neonatal rats.
Acute Kidney Injury
Adenosine kinase inhibition attenuates ischemia reperfusion-induced acute kidney injury.
Acute Kidney Injury
Adenosine kinase inhibition protects against cisplatin-induced nephrotoxicity.
Adenocarcinoma
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Adenocarcinoma
Pre-clinical evaluation of new antineoplastic agents in NSCLC cell lines: evidence of histological subtype-dependent cytotoxicity.
Adenoma
Univariate and multivariate analyses of the relationship between adenocarcinoma and solitary and multiple adenomas in colorectal adenoma patients.
adenosine kinase deficiency
Adenosine and tubercidin binding and transport in Chinese hamster ovary and Novikoff rat hepatoma cells.
adenosine kinase deficiency
Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function.
adenosine kinase deficiency
Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity.
adenosine kinase deficiency
Adenosine kinase deficiency in tritiated deoxyadenosine-resistant mouse S49 lymphoma cell lines.
adenosine kinase deficiency
Adenosine Kinase Deficiency Increases Susceptibility to a Carcinogen.
adenosine kinase deficiency
Adenosine kinase deficiency is associated with developmental abnormalities and reduced transmethylation.
adenosine kinase deficiency
Adenosine kinase deficiency with neurodevelopemental delay and recurrent hepatic dysfunction: A case report.
adenosine kinase deficiency
Adenosine kinase deficiency: expanding the clinical spectrum and evaluating therapeutic options.
adenosine kinase deficiency
Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia.
adenosine kinase deficiency
Clinical utility of methionine restriction in adenosine kinase deficiency.
adenosine kinase deficiency
Consensus recommendations for the diagnosis, treatment and follow-up of inherited methylation disorders.
adenosine kinase deficiency
Copy number variant in the region of adenosine kinase (ADK) and its possible contribution to schizophrenia susceptibility.
adenosine kinase deficiency
Deletion of pancreatic ?-cell adenosine kinase improves glucose homeostasis in young mice and ameliorates streptozotocin-induced hyperglycaemia.
adenosine kinase deficiency
Endothelial adenosine kinase deficiency ameliorates diet-induced insulin resistance.
adenosine kinase deficiency
Increased expression of one of two adenosine deaminase alleles in a human choriocarcinoma cell line following selection with adenine nucleosides.
adenosine kinase deficiency
Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines.
adenosine kinase deficiency
S-adenosylhomocysteine hydrolase inactivation and purine toxicity in cultured human T- and B-lymphoblasts.
adenosine kinase deficiency
S-adenosylmethionine induces mitochondrial dysfunction, permeability transition pore opening and redox imbalance in subcellular preparations of rat liver.
adenosine kinase deficiency
Targeted disruption of adenosine kinase in myeloid monocyte cells increases osteoclastogenesis and bone resorption in mice.
adenosine kinase deficiency
Whole exome sequencing revealed mutations in FBXL4, UNC80, and ADK in Thai patients with severe intellectual disabilities.
Anemia
Role of adenosine signaling in coordinating cardiomyocyte function and coronary vascular growth in chronic fetal anemia.
Arthritis, Experimental
Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis.
Astrocytoma
Stable Knockdown of Adenosine Kinase by Lentiviral Anti-ADK miR-shRNAs in Wharton's Jelly Stem Cells.
Atherosclerosis
Ablation of Myeloid ADK (Adenosine Kinase) Epigenetically Suppresses Atherosclerosis in ApoE-/- (Apolipoprotein E Deficient) Mice.
Atherosclerosis
Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation.
Bone Resorption
Targeted disruption of adenosine kinase in myeloid monocyte cells increases osteoclastogenesis and bone resorption in mice.
Brain Diseases
Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function.
Brain Injuries
Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.
Brain Injuries
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice.
Brain Injuries
Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation.
Brain Injuries
Pre- and peristroke treatment with the adenosine kinase inhibitor, 5'-deoxyiodotubercidin, significantly reduces infarct volume after temporary occlusion of the middle cerebral artery in rats.
Brain Injuries
Role of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A Potential Novel Drug for Epilepsy.
Brain Injuries
Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy.
Brain Injuries, Traumatic
Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury.
Brain Injuries, Traumatic
Adenosine kinase inhibition promotes proliferation of neural stem cells after traumatic brain injury.
Brain Injuries, Traumatic
Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development.
Brain Ischemia
Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.
Brain Ischemia
Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury.
Brain Ischemia
Adenosine kinase inhibition protects brain against transient focal ischemia in rats.
Breast Neoplasms
Intracellularly transported adenosine induces MCF-7 human breast cancer cells by accumulating AMID in the nucleus.
Breast Neoplasms
Preventive and curative effect of melatonin on mammary carcinogenesis induced by dimethylbenz[a]anthracene in the female Sprague-Dawley rat.
Carcinoma
Outcome of EGFR-mutated adenocarcinoma NSCLC patients with changed phenotype to squamous cell carcinoma after tyrosine kinase inhibitors: A pooled analysis with an additional case.
Carcinoma
Pre-clinical evaluation of new antineoplastic agents in NSCLC cell lines: evidence of histological subtype-dependent cytotoxicity.
Carcinoma
[Kinetics of degradation and resynthesis of the adenine-nucleotide pool in tumor cells]
Carcinoma, Ehrlich Tumor
Feedback inhibition by 6-methylthioinosine 3',5'-cyclic monophosphate in tumor cells resistant to the nucleoside.
Carcinoma, Ehrlich Tumor
Kinetic studies of adenosine kinase from Ehrlich ascites tumor cells.
Carcinoma, Hepatocellular
Adenosine deaminase and adenosine kinase in rat hepatomas and kidney tumours.
Carcinoma, Hepatocellular
Biochemical approaches to enhancement of antitumor drug selectivity: selective protection of cells from 6-thioguanine and 6-mercaptopurine by adenosine.
Carcinoma, Hepatocellular
Isolation of deoxycoformycin-resistant cells with increased levels of adenosine deaminase.
Carcinoma, Hepatocellular
Pyrazofurin-resistant hepatoma cells deficient in adenosine kinase.
Carcinoma, Hepatocellular
[Kinetics of degradation and resynthesis of the adenine-nucleotide pool in tumor cells]
Carcinoma, Squamous Cell
Outcome of EGFR-mutated adenocarcinoma NSCLC patients with changed phenotype to squamous cell carcinoma after tyrosine kinase inhibitors: A pooled analysis with an additional case.
Carcinoma, Squamous Cell
Pre-clinical evaluation of new antineoplastic agents in NSCLC cell lines: evidence of histological subtype-dependent cytotoxicity.
Cardiovascular Diseases
Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanisms.
Cholestasis
Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia.
Communicable Diseases
Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): profound asymmetry in the crystal structure of the 'open' state.
COVID-19
Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities.
Cystadenocarcinoma, Serous
A rare case of synchronous ovarian tumors: clinical case report and literature review.
Diabetes Mellitus
Decreased expression of adenosine kinase in streptozotocin-induced diabetes mellitus rats.
Diabetes Mellitus
Insulin restores expression of adenosine kinase in streptozotocin-induced diabetes mellitus rats.
Diabetes Mellitus, Type 1
Effect of diabetes/hyperglycemia on the rat retinal adenosinergic system.
Diabetes, Gestational
Adenosine kinase and cardiovascular fetal programming in gestational diabetes mellitus.
Diabetic Retinopathy
ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy.
Drug Resistant Epilepsy
A ketogenic diet suppresses seizures in mice through adenosine A? receptors.
Drug Resistant Epilepsy
Adenosine kinase as a target for therapeutic antisense strategies in epilepsy.
Drug Resistant Epilepsy
Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy.
Drug Resistant Epilepsy
Role of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A Potential Novel Drug for Epilepsy.
Epilepsy
Adenosine A(1) Receptors in the Central Nervous System: Their Functions in Health and Disease, and Possible Elucidation by PET Imaging.
Epilepsy
Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma?associated epilepsy.
Epilepsy
Adenosine kinase and adenosine receptors A1 R and A2A R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP.
Epilepsy
Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia.
Epilepsy
Adenosine kinase elevation increases activity in the kainic acid model of epilepsy.
Epilepsy
Adenosine kinase expression in cortical dysplasia with balloon cells: analysis of developmental lineage of cell types.
Epilepsy
Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury.
Epilepsy
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice.
Epilepsy
Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.
Epilepsy
Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.
Epilepsy
Computational exploration of vicine - an alkaloid glycoside mediated pathological hallmark of adenosine kinase to promote neurological disorder.
Epilepsy
Copy number variant in the region of adenosine kinase (ADK) and its possible contribution to schizophrenia susceptibility.
Epilepsy
Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation.
Epilepsy
Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development.
Epilepsy
Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy.
Epilepsy
Overexpression of adenosine kinase in cortical astrocytes and focal neocortical epilepsy in mice.
Epilepsy
Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis.
Epilepsy
Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy.
Epilepsy
Role of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A Potential Novel Drug for Epilepsy.
Epilepsy
South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase.
Epilepsy
Therapeutic epilepsy research: From pharmacological rationale to focal adenosine augmentation.
Epilepsy
Transient use of a systemic adenosine kinase inhibitor attenuates epilepsy development in mice.
Epilepsy
Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Adenosine kinase and adenosine receptors A1 R and A2A R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP.
Epilepsy, Temporal Lobe
Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.
Epilepsy, Temporal Lobe
Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis.
Epilepsy, Temporal Lobe
Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy.
Glioma
Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma?associated epilepsy.
Glucose Intolerance
Erratum. Genetic Disruption of Adenosine Kinase in Mouse Pancreatic ?-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance. Diabetes 2017;66:1928-1938.
Glucose Intolerance
Genetic Disruption of Adenosine Kinase in Mouse Pancreatic ?-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance.
Hearing Loss
Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss.
Heart Failure
Adenosine Kinase Inhibition Augments Conducted Vasodilation and Prevents Left Ventricle Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction.
Heart Failure
Adenosine kinase inhibition enhances microvascular dilator function and improves left ventricle diastolic dysfunction.
Hepatic Encephalopathy
Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity.
Hepatitis C
Effects of the aryl linker and the aromatic substituent on the anti-HCV activities of aryl diketoacid (ADK) analogues.
Hepatitis C
Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate-activated protein kinase-related kinases and retinoid X receptor ?.
Hepatitis C, Chronic
Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate-activated protein kinase-related kinases and retinoid X receptor ?.
Huntington Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Hyperalgesia
A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats.
Hyperalgesia
An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain.
Hyperalgesia
Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat.
Hyperalgesia
Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor.
Hyperalgesia
Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats.
Hyperalgesia
Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action.
Hyperalgesia
Pharmacological characterization of the chronic constriction injury model of neuropathic pain.
Hypertension
Adenosine deaminase: functional implications and different classes of inhibitors.
Hyperthyroidism
Hyperthyroidism increases adenosine transport and metabolism in the rat heart.
Hypoglycemia
Adenosine kinase deficiency: expanding the clinical spectrum and evaluating therapeutic options.
Hypotension
Adenosine kinase inhibitor GP515 attenuates hepatic leukocyte adhesion after hemorrhagic hypotension.
Hypothyroidism
Changes in the activities of adenosine-metabolizing enzymes in six regions of the rat brain on chemical induction of hypothyroidism.
Hypothyroidism
Enzymes involved in adenosine metabolism in rat white and brown adipocytes. Effects of streptozotocin-diabetes, hypothyroidism, age and sex differences.
Infarction, Middle Cerebral Artery
Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.
Infarction, Middle Cerebral Artery
Adenosine kinase inhibition protects brain against transient focal ischemia in rats.
Infarction, Middle Cerebral Artery
Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion.
Infarction, Middle Cerebral Artery
Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism.
Infarction, Middle Cerebral Artery
Neuroprotection in ischemic mouse brain induced by stem cell-derived brain implants.
Infarction, Middle Cerebral Artery
Pre- and peristroke treatment with the adenosine kinase inhibitor, 5'-deoxyiodotubercidin, significantly reduces infarct volume after temporary occlusion of the middle cerebral artery in rats.
Infarction, Middle Cerebral Artery
Transgenic overexpression of adenosine kinase aggravates cell death in ischemia.
Infections
Adenylate kinase: a novel antigen for immunodiagnosis and subunit vaccine against tuberculosis.
Infections
Immunogenicity and protective response induced by recombinant Brucella abortus proteins Adk, SecB and combination of these two recombinant proteins against a virulent strain B. abortus 544 infection in BALB/c mice.
Infections
Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities.
Infections
Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent.
Inflammatory Bowel Diseases
Adenosine kinase inhibitor GP515 improves experimental colitis in mice.
Insulin Resistance
Endothelial adenosine kinase deficiency ameliorates diet-induced insulin resistance.
Intellectual Disability
Whole exome sequencing revealed mutations in FBXL4, UNC80, and ADK in Thai patients with severe intellectual disabilities.
Ischemic Stroke
Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.
Kidney Diseases
"Adenosine an old player with new possibilities in kidney diseases": Preclinical evidences and clinical perspectives.
Leukemia
Enzymes of the purine interconversion system in chronic lymphatic leukemia: decreased purine nucleoside phosphorylase and adenosine deaminase activity.
Leukemia L1210
Use of nucleoside kinase-deficient mouse leukemia L1210 cell lines to determine metabolic routes of activation of antitumor nucleoside analogs.
Leukemia, Lymphocytic, Chronic, B-Cell
Enzymes of the purine interconversion system in chronic lymphatic leukemia: decreased purine nucleoside phosphorylase and adenosine deaminase activity.
Leukemia, Lymphocytic, Chronic, B-Cell
Enzymological studies in chronic lymphocytic leukemia.
Leukemia, Myeloid, Acute
Inhibition of adenosine and thymidylate kinases by bisubstrate analogs.
Liver Diseases
Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity.
Liver Diseases
Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia.
Liver Diseases
S-adenosylmethionine induces mitochondrial dysfunction, permeability transition pore opening and redox imbalance in subcellular preparations of rat liver.
Lymphatic Metastasis
Adenocarcinoma versus urothelial carcinoma of the urinary bladder: comparison between pathologic stage at radical cystectomy and cancer-specific mortality.
Lymphoma
Adenosine kinase deficiency in tritiated deoxyadenosine-resistant mouse S49 lymphoma cell lines.
Lymphoma
Effects of deoxycoformycin in mice. II. Differences between the drug sensitivities and purine metabolizing enzymes of transplantable lymphomas of varying immunologic phenotypes.
Lymphoma
Modulation of adenine nucleoside excretion and incorporation in adenosine deaminase deficient human lymphoma cells.
Lymphoproliferative Disorders
Adenosine deaminase: functional implications and different classes of inhibitors.
Malformations of Cortical Development
Adenosine kinase expression in cortical dysplasia with balloon cells: analysis of developmental lineage of cell types.
Malocclusion
Phenotype-genotype correlations of facial width and height proportions in patients with Class II malocclusion.
Melanoma
Nucleotide-metabolism and chromosome alterations in human-malignant melanoma xenografts.
Melanoma
Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells.
Melioidosis
Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): profound asymmetry in the crystal structure of the 'open' state.
Memory Disorders
Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia.
Memory Disorders
Working memory and the homeostatic control of brain adenosine by adenosine kinase.
Mitochondrial Diseases
Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia.
Multiple Myeloma
Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies.
Multiple Myeloma
Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-?-riboside-induced apoptosis in multiple myeloma cells.
Myocardial Infarction
Cardioprotection following adenosine kinase inhibition in rat hearts.
Neoplasm Metastasis
A rare case of synchronous ovarian tumors: clinical case report and literature review.
Neoplasm Metastasis
Adenocarcinoma versus urothelial carcinoma of the urinary bladder: comparison between pathologic stage at radical cystectomy and cancer-specific mortality.
Neoplasm Metastasis
Diverticular disease and colon cancer: a real association between the two diseases?
Neoplasm Metastasis
Optimal Treatment of cT2N0 Esophageal Carcinoma: Is Upfront Surgery Really the Way?
Neoplasms
5'-Iodotubercidin represses insulinoma associated-1 expression, decreases cAMP levels, and suppresses human neuroblastoma cell growth.
Neoplasms
A rare case of synchronous ovarian tumors: clinical case report and literature review.
Neoplasms
A rational approach to personalized anticancer therapy: chemoinformatic analysis reveals mechanistic gene-drug associations.
Neoplasms
Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma?associated epilepsy.
Neoplasms
Adenosine Inhibits Cell Proliferation Differently in Human Astrocytes and in Glioblastoma Cell Lines.
Neoplasms
Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury.
Neoplasms
Cancer cells govern miR-2909 exosomal recruitment through its 3'-end post-transcriptional modification.
Neoplasms
Chronic Morphine-Induced Changes in Signaling at the A3 Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal.
Neoplasms
Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia.
Neoplasms
Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation.
Neoplasms
Feedback inhibition by 6-methylthioinosine 3',5'-cyclic monophosphate in tumor cells resistant to the nucleoside.
Neoplasms
Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies.
Neoplasms
Ki-67 and p53 immunostaining assessment of proliferative activity in salivary tumors.
Neoplasms
Optimal Treatment of cT2N0 Esophageal Carcinoma: Is Upfront Surgery Really the Way?
Neoplasms
Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy.
Neoplasms
Protein expression during lag phase and growth initiation in Saccharomyces cerevisiae.
Neoplasms
Purification and properties of adenosine kinase from human tumor cells of type H. Ep. No. 2.
Neoplasms
Studies on the mechanism of cytotoxicity of 3'-deoxyadenosine N1-oxide in different strains of Ehrlich ascites tumor cells.
Neoplasms
The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine.
Neoplasms
Vascular endothelial growth factor (VEGF) expression and microvascular density in salivary gland tumours.
Neoplasms
[Adenocarcinomas of the ethmoid sinus: retrospective analysis of prognostic factors]
Neoplasms
[Delayed hypersensitivity and nonspecific cellular immunity. The cytotoxic activity of macrophages, natural and antibody-dependent killer cells]
Nervous System Diseases
Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia.
Nervous System Diseases
Computational exploration of vicine - an alkaloid glycoside mediated pathological hallmark of adenosine kinase to promote neurological disorder.
Nervous System Diseases
Homeostatic Control of Synaptic Activity by Endogenous Adenosine is Mediated by Adenosine Kinase.
Neuralgia
An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain.
Neuralgia
Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.
Neuroblastoma
Adenosine transport by a variant of C1300 murine neuroblastoma cells deficient in adenosine kinase.
Neurodegenerative Diseases
Co-administration of adenosine kinase and deaminase inhibitors produces supra-additive potentiation of N-methyl-D-aspartate-evoked adenosine formation in cortex.
Neutropenia
Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine.
Neutropenia
Pathway genes and metabolites in thiopurine therapy in Korean children with acute lymphoblastic leukaemia.
Optic Nerve Injuries
Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy.
Osteoarthritis
The effect of negative randomized trials and surgeon volume on the rates of arthroscopy for patients with knee OA.
Overweight
Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate-activated protein kinase-related kinases and retinoid X receptor ?.
Parkinson Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Parkinsonian Disorders
Copy number variant in the region of adenosine kinase (ADK) and its possible contribution to schizophrenia susceptibility.
Peripheral Nerve Injuries
The effect of ABT-702, a novel adenosine kinase inhibitor, on the responses of spinal neurones following carrageenan inflammation and peripheral nerve injury.
Peritoneal Neoplasms
Diverticular disease and colon cancer: a real association between the two diseases?
Proteinuria
Carbonic adsorbent AST-120 retards progression of renal failure by additive effect with ACEI and protein restriction diet.
Respiratory Distress Syndrome
Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities.
Respiratory Insufficiency
The effect of GP683, an adenosine kinase inhibitor, on the desflurane anesthetic requirement in dogs.
Sarcoma 180
Adenosine kinase of sarcoma 180 cells N 6 -substituted adenosines as substrates and inhibitors.
Seizures
Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity.
Seizures
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice.
Seizures
Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.
Seizures
Adenosine: front and center in linking nutrition and metabolism to neuronal activity.
Seizures
Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus.
Seizures
Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.
Seizures
Co-administration of adenosine kinase and deaminase inhibitors produces supra-additive potentiation of N-methyl-D-aspartate-evoked adenosine formation in cortex.
Seizures
Computational exploration of vicine - an alkaloid glycoside mediated pathological hallmark of adenosine kinase to promote neurological disorder.
Seizures
Discovery and identification of putative adenosine kinase inhibitors as potential anti-epileptic agents from structural insights.
Seizures
Discovery and optimization of 2-aryl oxazolo-pyrimidines as adenosine kinase inhibitors using liquid phase parallel synthesis.
Seizures
Engineered adenosine-releasing cells for epilepsy therapy: human mesenchymal stem cells and human embryonic stem cells.
Seizures
Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development.
Seizures
Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy.
Seizures
Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: A novel perspective for seizure control.
Seizures
Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: a first step in epileptogenesis?
Seizures
Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility.
Seizures
Modulatory role of adenosine and its receptors in epilepsy: Possible therapeutic approaches.
Seizures
Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis.
Seizures
Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy.
Seizures
Potentiation of excitatory amino acid-evoked adenosine release from rat cortex by inhibitors of adenosine kinase and adenosine deaminase and by acadesine.
Seizures
Role of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A Potential Novel Drug for Epilepsy.
Seizures
Seizure suppression and lack of adenosine A1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts.
Seizures
Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme.
Seizures
South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase.
Seizures
The support of adenosine release from adenosine kinase deficient ES cells by silk substrates.
Seizures
Therapeutic epilepsy research: From pharmacological rationale to focal adenosine augmentation.
Seizures
Uncoupling of astrogliosis from epileptogenesis in adenosine kinase (ADK) transgenic mice.
Sexually Transmitted Diseases
Population genetics of Neisseria gonorrhoeae in a high-prevalence community using a hypervariable outer membrane porB and 13 slowly evolving housekeeping genes.
Sleep Deprivation
Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation.
Starvation
AMP deaminase in Dictyostelium discoideum: increase in activity following nutrient deprivation induced by starvation or hadacidin.
Starvation
The control of cell proliferation by preformed purines: a genetic study. I. Isolation and preliminary characterization of Chinese hamster lines with single or multiple defects in purine "salvage" pathways.
Status Epilepticus
Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.
Status Epilepticus
Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: A novel perspective for seizure control.
Status Epilepticus
Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy.
Stroke
Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.
Stroke
Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism.
Stroke
Modulation of ischemic brain injury and neuroinflammation by adenosine A2A receptors.
Sudden Unexpected Death in Epilepsy
Adenosine kinase and adenosine receptors A1 R and A2A R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP.
Thrombosis
Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities.
Toxoplasmosis
Synthesis, biological activity and molecular modeling of 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase.
Tremor
Adenosine kinase inhibitors attenuate opiate withdrawal via adenosine receptor activation.
Triple Negative Breast Neoplasms
Dysregulation of adenosine kinase isoforms in breast cancer.
Tuberculosis
2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity.
Tuberculosis
A new subfamily of short bacterial adenylate kinases with the Mycobacterium tuberculosis enzyme as a model: A predictive and experimental study.
Tuberculosis
Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase.
Tuberculosis
Evaluation of 3-deaza-adenosine analogues as ligands for adenosine kinase and inhibitors of Mycobacterium tuberculosis growth.
Tuberculosis
High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme.
Tuberculosis
Identification and characterization of a unique adenosine kinase from Mycobacterium tuberculosis.
Tuberculosis
Overexpression, purification and crystallographic analysis of a unique adenosine kinase from Mycobacterium tuberculosis.
Tuberculosis
Purine metabolism in Mycobacterium tuberculosis as a target for drug development.
Tuberculosis
Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(Het)aryl-7-deazaadenine ribonucleosides.
Tuberculosis
Structure-activity relationship for adenosine kinase from Mycobacterium tuberculosis II. Modifications to the ribofuranosyl moiety.
Tuberculosis
Structure-activity relationship for nucleoside analogs as inhibitors or substrates of adenosine kinase from Mycobacterium tuberculosis. I. Modifications to the adenine moiety.
Tuberculosis
Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.
Vaccinia
9-(trans-2',trans-3'-Dihydroxycyclopent-4'-enyl)-adenine and -3-deazaadenine: analogs of neplanocin A which retain potent antiviral activity but exhibit reduced cytotoxicity.
Vascular Diseases
Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation.
Vascular Diseases
Therapeutic potential of adenosine kinase inhibition in vascular disease.
Vascular System Injuries
Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation.
Whooping Cough
Structural and physico-chemical characteristics of Bordetella pertussis adenylate kinase, a tryptophan-containing enzyme.
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