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Disease on EC 2.7.1.20 - adenosine kinase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
5'-nucleotidase deficiency
Inborn errors of purine metabolism: clinical update and therapies.
Acidosis
Involvement of adenosine in depression of synaptic transmission during hypercapnia in isolated spinal cord of neonatal rats.
Acute Kidney Injury
Adenosine kinase inhibition attenuates ischemia reperfusion-induced acute kidney injury.
Adenosine kinase inhibition protects against cisplatin-induced nephrotoxicity.
Acute Lung Injury
Inhibition of Adenosine Kinase Attenuates Acute Lung Injury.
Adenocarcinoma
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Microscopic morphometry--a modern approach.
Pre-clinical evaluation of new antineoplastic agents in NSCLC cell lines: evidence of histological subtype-dependent cytotoxicity.
Adenoma
Univariate and multivariate analyses of the relationship between adenocarcinoma and solitary and multiple adenomas in colorectal adenoma patients.
adenosine kinase deficiency
Adenosine and tubercidin binding and transport in Chinese hamster ovary and Novikoff rat hepatoma cells.
Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function.
Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity.
Adenosine kinase deficiency in tritiated deoxyadenosine-resistant mouse S49 lymphoma cell lines.
Adenosine Kinase Deficiency Increases Susceptibility to a Carcinogen.
Adenosine kinase deficiency is associated with developmental abnormalities and reduced transmethylation.
Adenosine kinase deficiency with neurodevelopemental delay and recurrent hepatic dysfunction: A case report.
Adenosine kinase deficiency: expanding the clinical spectrum and evaluating therapeutic options.
Adenosine Kinase Deficiency: Report and Review.
Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia.
Clinical utility of methionine restriction in adenosine kinase deficiency.
Consensus recommendations for the diagnosis, treatment and follow-up of inherited methylation disorders.
Copy number variant in the region of adenosine kinase (ADK) and its possible contribution to schizophrenia susceptibility.
Deletion of pancreatic ?-cell adenosine kinase improves glucose homeostasis in young mice and ameliorates streptozotocin-induced hyperglycaemia.
Endothelial adenosine kinase deficiency ameliorates diet-induced insulin resistance.
Increased expression of one of two adenosine deaminase alleles in a human choriocarcinoma cell line following selection with adenine nucleosides.
MRI and (1)H-MRS in adenosine kinase deficiency.
Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines.
S-adenosylhomocysteine hydrolase inactivation and purine toxicity in cultured human T- and B-lymphoblasts.
S-adenosylmethionine induces mitochondrial dysfunction, permeability transition pore opening and redox imbalance in subcellular preparations of rat liver.
Targeted disruption of adenosine kinase in myeloid monocyte cells increases osteoclastogenesis and bone resorption in mice.
Whole exome sequencing revealed mutations in FBXL4, UNC80, and ADK in Thai patients with severe intellectual disabilities.
Amyotrophic Lateral Sclerosis
Metabolic Aspects of Adenosine Functions in the Brain.
Anemia
Role of adenosine signaling in coordinating cardiomyocyte function and coronary vascular growth in chronic fetal anemia.
Aniridia
Mutation of the PAX6 gene in patients with autosomal dominant keratitis.
Arthritis, Experimental
Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis.
Astrocytoma
Stable Knockdown of Adenosine Kinase by Lentiviral Anti-ADK miR-shRNAs in Wharton's Jelly Stem Cells.
Atherosclerosis
Ablation of Myeloid ADK (Adenosine Kinase) Epigenetically Suppresses Atherosclerosis in ApoE-/- (Apolipoprotein E Deficient) Mice.
Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation.
Bone Resorption
Targeted disruption of adenosine kinase in myeloid monocyte cells increases osteoclastogenesis and bone resorption in mice.
Brain Diseases
Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function.
[Neuroprotective mechanisms of adenosine action on CNS neurons]
Brain Injuries
Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice.
Adenosine kinase, epilepsy and stroke: mechanisms and therapies.
Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation.
Pre- and peristroke treatment with the adenosine kinase inhibitor, 5'-deoxyiodotubercidin, significantly reduces infarct volume after temporary occlusion of the middle cerebral artery in rats.
Role of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A Potential Novel Drug for Epilepsy.
The adenosine kinase hypothesis of epileptogenesis.
Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy.
Brain Injuries, Traumatic
Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury.
Adenosine kinase inhibition promotes proliferation of neural stem cells after traumatic brain injury.
Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development.
Brain Ischemia
Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.
Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury.
Adenosine kinase inhibition protects brain against transient focal ischemia in rats.
Breast Neoplasms
Dysregulation of adenosine kinase isoforms in breast cancer.
Intracellularly transported adenosine induces MCF-7 human breast cancer cells by accumulating AMID in the nucleus.
Preventive and curative effect of melatonin on mammary carcinogenesis induced by dimethylbenz[a]anthracene in the female Sprague-Dawley rat.
Carcinogenesis
Dysregulation of adenosine kinase isoforms in breast cancer.
Carcinoma
Outcome of EGFR-mutated adenocarcinoma NSCLC patients with changed phenotype to squamous cell carcinoma after tyrosine kinase inhibitors: A pooled analysis with an additional case.
Pre-clinical evaluation of new antineoplastic agents in NSCLC cell lines: evidence of histological subtype-dependent cytotoxicity.
[Kinetics of degradation and resynthesis of the adenine-nucleotide pool in tumor cells]
Carcinoma, Ehrlich Tumor
Feedback inhibition by 6-methylthioinosine 3',5'-cyclic monophosphate in tumor cells resistant to the nucleoside.
Kinetic studies of adenosine kinase from Ehrlich ascites tumor cells.
Carcinoma, Hepatocellular
Adenosine deaminase and adenosine kinase in rat hepatomas and kidney tumours.
Biochemical approaches to enhancement of antitumor drug selectivity: selective protection of cells from 6-thioguanine and 6-mercaptopurine by adenosine.
Isolation of deoxycoformycin-resistant cells with increased levels of adenosine deaminase.
Pyrazofurin-resistant hepatoma cells deficient in adenosine kinase.
Rat hepatomas: chemotherapy with lycurim and pyrazofurin.
[Kinetics of degradation and resynthesis of the adenine-nucleotide pool in tumor cells]
Carcinoma, Squamous Cell
Outcome of EGFR-mutated adenocarcinoma NSCLC patients with changed phenotype to squamous cell carcinoma after tyrosine kinase inhibitors: A pooled analysis with an additional case.
Pre-clinical evaluation of new antineoplastic agents in NSCLC cell lines: evidence of histological subtype-dependent cytotoxicity.
Cardiovascular Diseases
Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanisms.
Cholestasis
Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia.
Cholesteatoma
Proteomic analysis of cholesteatoma.
Colitis
Adenosine kinase inhibitor GP515 improves experimental colitis in mice.
Colorectal Neoplasms
Adenosine kinase gene expression in human colorectal cancer.
Communicable Diseases
Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): profound asymmetry in the crystal structure of the 'open' state.
COVID-19
Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities.
Cystadenocarcinoma, Serous
A rare case of synchronous ovarian tumors: clinical case report and literature review.
Diabetes Mellitus
Decreased expression of adenosine kinase in streptozotocin-induced diabetes mellitus rats.
Insulin restores expression of adenosine kinase in streptozotocin-induced diabetes mellitus rats.
Diabetes Mellitus, Type 1
Effect of diabetes/hyperglycemia on the rat retinal adenosinergic system.
Diabetes, Gestational
Adenosine kinase and cardiovascular fetal programming in gestational diabetes mellitus.
Diabetic Retinopathy
ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy.
Drug Resistant Epilepsy
A ketogenic diet suppresses seizures in mice through adenosine A? receptors.
Adenosine kinase as a target for therapeutic antisense strategies in epilepsy.
Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy.
Role of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A Potential Novel Drug for Epilepsy.
Encephalitis
Upregulation of adenosine kinase in Rasmussen encephalitis.
Epilepsy
Adenosine A(1) Receptors in the Central Nervous System: Their Functions in Health and Disease, and Possible Elucidation by PET Imaging.
Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma?associated epilepsy.
Adenosine dysfunction and adenosine kinase in epileptogenesis.
Adenosine dysfunction in astrogliosis: cause for seizure generation?
Adenosine dysfunction in epilepsy.
Adenosine kinase and adenosine receptors A1 R and A2A R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP.
Adenosine kinase as a target for therapeutic antisense strategies in epilepsy.
Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia.
Adenosine kinase elevation increases activity in the kainic acid model of epilepsy.
Adenosine kinase expression in cortical dysplasia with balloon cells: analysis of developmental lineage of cell types.
Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury.
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice.
Adenosine kinase, epilepsy and stroke: mechanisms and therapies.
Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.
Adenosine kinase: A key regulator of purinergic physiology.
Adenosine kinase: exploitation for therapeutic gain.
Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.
Comorbidities in Neurology: Is adenosine the common link?
Computational exploration of vicine - an alkaloid glycoside mediated pathological hallmark of adenosine kinase to promote neurological disorder.
Copy number variant in the region of adenosine kinase (ADK) and its possible contribution to schizophrenia susceptibility.
Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation.
Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development.
Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy.
Inhibitory RNA in epilepsy: research tools and therapeutic perspectives.
Metabolic Aspects of Adenosine Functions in the Brain.
MRI and (1)H-MRS in adenosine kinase deficiency.
Overexpression of adenosine kinase in cortical astrocytes and focal neocortical epilepsy in mice.
Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis.
Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy.
Role of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A Potential Novel Drug for Epilepsy.
Role of the purinergic signaling in epilepsy.
South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase.
Therapeutic epilepsy research: From pharmacological rationale to focal adenosine augmentation.
Transgenic overexpression of adenosine kinase aggravates cell death in ischemia.
Transient use of a systemic adenosine kinase inhibitor attenuates epilepsy development in mice.
Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy.
Upregulation of adenosine kinase in Rasmussen encephalitis.
Epilepsy, Temporal Lobe
Adenosine dysfunction in epilepsy.
Adenosine kinase and adenosine receptors A1 R and A2A R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP.
Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.
Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.
Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis.
Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy.
Glioma
Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma?associated epilepsy.
Glomerulonephritis
Glomerulopathy in adult recipients of pediatric kidneys.
Glucose Intolerance
Erratum. Genetic Disruption of Adenosine Kinase in Mouse Pancreatic ?-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance. Diabetes 2017;66:1928-1938.
Genetic Disruption of Adenosine Kinase in Mouse Pancreatic ?-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance.
Gout
Erythrocyte adenosine kinase activity in gout.
Hearing Loss
Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss.
Heart Failure
Adenosine Kinase Inhibition Augments Conducted Vasodilation and Prevents Left Ventricle Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction.
Adenosine kinase inhibition enhances microvascular dilator function and improves left ventricle diastolic dysfunction.
Hepatic Encephalopathy
Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity.
Hepatitis C
Effects of the aryl linker and the aromatic substituent on the anti-HCV activities of aryl diketoacid (ADK) analogues.
Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate-activated protein kinase-related kinases and retinoid X receptor ?.
Hepatitis C, Chronic
Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate-activated protein kinase-related kinases and retinoid X receptor ?.
HIV Infections
Kinases: Understanding Their Role in HIV Infection.
Huntington Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Metabolic Aspects of Adenosine Functions in the Brain.
Hyperalgesia
A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats.
An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain.
Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat.
Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor.
Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats.
Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action.
Pharmacological characterization of the chronic constriction injury model of neuropathic pain.
Hyperglycemia
Effect of diabetes/hyperglycemia on the rat retinal adenosinergic system.
Hypertension
Adenosine deaminase: functional implications and different classes of inhibitors.
Hyperthyroidism
Hyperthyroidism increases adenosine transport and metabolism in the rat heart.
Hypoglycemia
Adenosine kinase deficiency: expanding the clinical spectrum and evaluating therapeutic options.
Hypotension
Adenosine kinase inhibitor GP515 attenuates hepatic leukocyte adhesion after hemorrhagic hypotension.
Hypothyroidism
Changes in the activities of adenosine-metabolizing enzymes in six regions of the rat brain on chemical induction of hypothyroidism.
Enzymes involved in adenosine metabolism in rat white and brown adipocytes. Effects of streptozotocin-diabetes, hypothyroidism, age and sex differences.
Infarction, Middle Cerebral Artery
Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.
Adenosine kinase inhibition protects brain against transient focal ischemia in rats.
Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion.
Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism.
Neuroprotection in ischemic mouse brain induced by stem cell-derived brain implants.
Pre- and peristroke treatment with the adenosine kinase inhibitor, 5'-deoxyiodotubercidin, significantly reduces infarct volume after temporary occlusion of the middle cerebral artery in rats.
Transgenic overexpression of adenosine kinase aggravates cell death in ischemia.
Infections
Adenylate kinase: a novel antigen for immunodiagnosis and subunit vaccine against tuberculosis.
Immunogenicity and protective response induced by recombinant Brucella abortus proteins Adk, SecB and combination of these two recombinant proteins against a virulent strain B. abortus 544 infection in BALB/c mice.
Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities.
Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent.
Viral genome methylation as an epigenetic defense against geminiviruses.
Inflammatory Bowel Diseases
Adenosine kinase inhibitor GP515 improves experimental colitis in mice.
Insulin Resistance
Endothelial adenosine kinase deficiency ameliorates diet-induced insulin resistance.
Intellectual Disability
Whole exome sequencing revealed mutations in FBXL4, UNC80, and ADK in Thai patients with severe intellectual disabilities.
Ischemic Stroke
Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.
Kidney Diseases
"Adenosine an old player with new possibilities in kidney diseases": Preclinical evidences and clinical perspectives.
Leukemia
Biochemical mode of cytotoxic action of neplanocin A in L1210 leukemic cells.
Enzymes of the purine interconversion system in chronic lymphatic leukemia: decreased purine nucleoside phosphorylase and adenosine deaminase activity.
Leukemia L1210
Use of nucleoside kinase-deficient mouse leukemia L1210 cell lines to determine metabolic routes of activation of antitumor nucleoside analogs.
Leukemia, Lymphocytic, Chronic, B-Cell
Enzymes of the purine interconversion system in chronic lymphatic leukemia: decreased purine nucleoside phosphorylase and adenosine deaminase activity.
Enzymological studies in chronic lymphocytic leukemia.
Leukemia, Myeloid, Acute
Inhibition of adenosine and thymidylate kinases by bisubstrate analogs.
Liver Diseases
Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity.
Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia.
S-adenosylmethionine induces mitochondrial dysfunction, permeability transition pore opening and redox imbalance in subcellular preparations of rat liver.
Liver Neoplasms
Adenosine Kinase Deficiency Increases Susceptibility to a Carcinogen.
Lung Injury
Inhibition of Adenosine Kinase Attenuates Acute Lung Injury.
Lymphatic Metastasis
Adenocarcinoma versus urothelial carcinoma of the urinary bladder: comparison between pathologic stage at radical cystectomy and cancer-specific mortality.
Prediction of lymph node status in superficial esophageal carcinoma.
Lymphoma
Adenosine kinase deficiency in tritiated deoxyadenosine-resistant mouse S49 lymphoma cell lines.
Effects of deoxycoformycin in mice. II. Differences between the drug sensitivities and purine metabolizing enzymes of transplantable lymphomas of varying immunologic phenotypes.
Modulation of adenine nucleoside excretion and incorporation in adenosine deaminase deficient human lymphoma cells.
Lymphoproliferative Disorders
Adenosine deaminase: functional implications and different classes of inhibitors.
Malformations of Cortical Development
Adenosine kinase expression in cortical dysplasia with balloon cells: analysis of developmental lineage of cell types.
Malocclusion
Phenotype-genotype correlations of facial width and height proportions in patients with Class II malocclusion.
Melanoma
Nucleotide-metabolism and chromosome alterations in human-malignant melanoma xenografts.
Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells.
Melioidosis
Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): profound asymmetry in the crystal structure of the 'open' state.
Memory Disorders
Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia.
Working memory and the homeostatic control of brain adenosine by adenosine kinase.
Mitochondrial Diseases
Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia.
Multiple Myeloma
Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies.
Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-?-riboside-induced apoptosis in multiple myeloma cells.
Muscle Hypotonia
Adenosine Kinase Deficiency: Report and Review.
MRI and (1)H-MRS in adenosine kinase deficiency.
Myocardial Infarction
Cardioprotection following adenosine kinase inhibition in rat hearts.
Myoma
Unexpected location of endometrial adenocarcinoma - a case report.
Neoplasm Metastasis
A rare case of synchronous ovarian tumors: clinical case report and literature review.
Adenocarcinoma versus urothelial carcinoma of the urinary bladder: comparison between pathologic stage at radical cystectomy and cancer-specific mortality.
Diverticular disease and colon cancer: a real association between the two diseases?
Dysregulation of adenosine kinase isoforms in breast cancer.
Fronto-orbital metastasis of a prostatic adenocarcinoma.
Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis.
Optimal Treatment of cT2N0 Esophageal Carcinoma: Is Upfront Surgery Really the Way?
Prediction of lymph node status in superficial esophageal carcinoma.
Neoplasms
5'-Iodotubercidin represses insulinoma associated-1 expression, decreases cAMP levels, and suppresses human neuroblastoma cell growth.
A rare case of synchronous ovarian tumors: clinical case report and literature review.
A rational approach to personalized anticancer therapy: chemoinformatic analysis reveals mechanistic gene-drug associations.
Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma?associated epilepsy.
Adenosine deaminase and adenosine kinase in rat hepatomas and kidney tumours.
Adenosine Inhibits Cell Proliferation Differently in Human Astrocytes and in Glioblastoma Cell Lines.
Adenosine Kinase Deficiency Increases Susceptibility to a Carcinogen.
Adenosine Kinase Expression Determines DNA Methylation in Cancer Cell Lines.
Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury.
Adenosine kinase gene expression in human colorectal cancer.
Adenosine kinase: exploitation for therapeutic gain.
Animal models of the cancer anorexia-cachexia syndrome.
Cancer cells govern miR-2909 exosomal recruitment through its 3'-end post-transcriptional modification.
Chronic Morphine-Induced Changes in Signaling at the A3 Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal.
Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia.
Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation.
Dysregulation of adenosine kinase isoforms in breast cancer.
Feedback inhibition by 6-methylthioinosine 3',5'-cyclic monophosphate in tumor cells resistant to the nucleoside.
Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies.
Ki-67 and p53 immunostaining assessment of proliferative activity in salivary tumors.
Kinetic studies of adenosine kinase from Ehrlich ascites tumor cells.
Optimal Treatment of cT2N0 Esophageal Carcinoma: Is Upfront Surgery Really the Way?
Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy.
Protein expression during lag phase and growth initiation in Saccharomyces cerevisiae.
Purification and properties of adenosine kinase from human tumor cells of type H. Ep. No. 2.
Purine metabolism of human glioblastoma in vivo.
Studies on the mechanism of cytotoxicity of 3'-deoxyadenosine N1-oxide in different strains of Ehrlich ascites tumor cells.
The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine.
Vascular endothelial growth factor (VEGF) expression and microvascular density in salivary gland tumours.
[Adenocarcinomas of the ethmoid sinus: retrospective analysis of prognostic factors]
[Delayed hypersensitivity and nonspecific cellular immunity. The cytotoxic activity of macrophages, natural and antibody-dependent killer cells]
Nervous System Diseases
Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia.
Computational exploration of vicine - an alkaloid glycoside mediated pathological hallmark of adenosine kinase to promote neurological disorder.
Homeostatic Control of Synaptic Activity by Endogenous Adenosine is Mediated by Adenosine Kinase.
Neuralgia
An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain.
Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.
Neuroblastoma
Adenosine transport by a variant of C1300 murine neuroblastoma cells deficient in adenosine kinase.
Neurodegenerative Diseases
Co-administration of adenosine kinase and deaminase inhibitors produces supra-additive potentiation of N-methyl-D-aspartate-evoked adenosine formation in cortex.
Metabolic Aspects of Adenosine Functions in the Brain.
Neutropenia
Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine.
Pathway genes and metabolites in thiopurine therapy in Korean children with acute lymphoblastic leukaemia.
Obesity
Obesity and diabetes: Adenosine kinase inhibitor increases ?-cells.
Optic Nerve Injuries
Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy.
Osteoarthritis
The effect of negative randomized trials and surgeon volume on the rates of arthroscopy for patients with knee OA.
Overweight
Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate-activated protein kinase-related kinases and retinoid X receptor ?.
Parkinson Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Parkinsonian Disorders
Copy number variant in the region of adenosine kinase (ADK) and its possible contribution to schizophrenia susceptibility.
Peripheral Nerve Injuries
The effect of ABT-702, a novel adenosine kinase inhibitor, on the responses of spinal neurones following carrageenan inflammation and peripheral nerve injury.
Peritoneal Neoplasms
Diverticular disease and colon cancer: a real association between the two diseases?
Pneumonia
Inhibition of Adenosine Kinase Attenuates Acute Lung Injury.
Proteinuria
Carbonic adsorbent AST-120 retards progression of renal failure by additive effect with ACEI and protein restriction diet.
Respiratory Distress Syndrome
Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities.
Respiratory Insufficiency
The effect of GP683, an adenosine kinase inhibitor, on the desflurane anesthetic requirement in dogs.
Sarcoma 180
Adenosine kinase of sarcoma 180 cells N 6 -substituted adenosines as substrates and inhibitors.
Seizures
Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies.
Adenosine dysfunction and adenosine kinase in epileptogenesis.
Adenosine dysfunction in astrogliosis: cause for seizure generation?
Adenosine dysfunction in epilepsy.
Adenosine kinase as a target for therapeutic antisense strategies in epilepsy.
Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity.
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice.
Adenosine kinase, epilepsy and stroke: mechanisms and therapies.
Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.
Adenosine: front and center in linking nutrition and metabolism to neuronal activity.
Astrocyte and Neuronal Pannexin1 Contribute Distinctly to Seizures.
Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus.
Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.
Co-administration of adenosine kinase and deaminase inhibitors produces supra-additive potentiation of N-methyl-D-aspartate-evoked adenosine formation in cortex.
Comorbidities in Neurology: Is adenosine the common link?
Computational exploration of vicine - an alkaloid glycoside mediated pathological hallmark of adenosine kinase to promote neurological disorder.
Discovery and identification of putative adenosine kinase inhibitors as potential anti-epileptic agents from structural insights.
Discovery and optimization of 2-aryl oxazolo-pyrimidines as adenosine kinase inhibitors using liquid phase parallel synthesis.
Engineered adenosine-releasing cells for epilepsy therapy: human mesenchymal stem cells and human embryonic stem cells.
Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development.
Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy.
Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy.
Inhibitory RNA in epilepsy: research tools and therapeutic perspectives.
Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: A novel perspective for seizure control.
Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: a first step in epileptogenesis?
Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility.
Modulatory role of adenosine and its receptors in epilepsy: Possible therapeutic approaches.
Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis.
Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy.
Potentiation of excitatory amino acid-evoked adenosine release from rat cortex by inhibitors of adenosine kinase and adenosine deaminase and by acadesine.
Role of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A Potential Novel Drug for Epilepsy.
Role of the purinergic signaling in epilepsy.
Seizure suppression and lack of adenosine A1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts.
Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme.
South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase.
The adenosine kinase hypothesis of epileptogenesis.
The antiepileptic potential of nucleosides.
The role of adenosine in epilepsy.
The support of adenosine release from adenosine kinase deficient ES cells by silk substrates.
Therapeutic epilepsy research: From pharmacological rationale to focal adenosine augmentation.
Uncoupling of astrogliosis from epileptogenesis in adenosine kinase (ADK) transgenic mice.
Upregulation of Neuronal Adenosine A1 Receptor in Human Rasmussen Encephalitis.
Sexually Transmitted Diseases
Population genetics of Neisseria gonorrhoeae in a high-prevalence community using a hypervariable outer membrane porB and 13 slowly evolving housekeeping genes.
Shock, Septic
Protective effect of an adenosine kinase inhibitor in septic shock.
Sleep Deprivation
Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation.
Starvation
Adenosine uptake-dependent C6 cell growth inhibition.
AMP deaminase in Dictyostelium discoideum: increase in activity following nutrient deprivation induced by starvation or hadacidin.
The control of cell proliferation by preformed purines: a genetic study. I. Isolation and preliminary characterization of Chinese hamster lines with single or multiple defects in purine "salvage" pathways.
Status Epilepticus
Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.
Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: A novel perspective for seizure control.
Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy.
Stroke
Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.
Adenosine kinase is a new therapeutic target to prevent ischemic neuronal death.
Adenosine kinase, epilepsy and stroke: mechanisms and therapies.
Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism.
Modulation of ischemic brain injury and neuroinflammation by adenosine A2A receptors.
Sudden Unexpected Death in Epilepsy
Adenosine kinase and adenosine receptors A1 R and A2A R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP.
Thrombosis
Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities.
Toxoplasmosis
Synthesis, biological activity and molecular modeling of 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase.
Tremor
Adenosine kinase inhibitors attenuate opiate withdrawal via adenosine receptor activation.
Triple Negative Breast Neoplasms
Dysregulation of adenosine kinase isoforms in breast cancer.
Tuberculosis
2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity.
A new subfamily of short bacterial adenylate kinases with the Mycobacterium tuberculosis enzyme as a model: A predictive and experimental study.
Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase.
Evaluation of 3-deaza-adenosine analogues as ligands for adenosine kinase and inhibitors of Mycobacterium tuberculosis growth.
High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme.
Identification and characterization of a unique adenosine kinase from Mycobacterium tuberculosis.
Metabolism of 2-methyladenosine in Mycobacterium tuberculosis.
Overexpression, purification and crystallographic analysis of a unique adenosine kinase from Mycobacterium tuberculosis.
Purine metabolism in Mycobacterium tuberculosis as a target for drug development.
Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(Het)aryl-7-deazaadenine ribonucleosides.
Structure-activity relationship for adenosine kinase from Mycobacterium tuberculosis II. Modifications to the ribofuranosyl moiety.
Structure-activity relationship for nucleoside analogs as inhibitors or substrates of adenosine kinase from Mycobacterium tuberculosis. I. Modifications to the adenine moiety.
Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.
Vaccinia
9-(trans-2',trans-3'-Dihydroxycyclopent-4'-enyl)-adenine and -3-deazaadenine: analogs of neplanocin A which retain potent antiviral activity but exhibit reduced cytotoxicity.
Vascular Diseases
Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation.
Therapeutic potential of adenosine kinase inhibition in vascular disease.
Vascular System Injuries
Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation.
Whooping Cough
Structural and physico-chemical characteristics of Bordetella pertussis adenylate kinase, a tryptophan-containing enzyme.