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Literature summary for 2.7.1.20 extracted from

  • Zhang, Y.; El Kouni, M.H.; Ealick, S.E.
    Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 A resolution (2006), Acta Crystallogr. Sect. D, 62, 140-145.
    View publication on PubMed
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Application

Application Comment Organism
medicine adenosine kinase represents a potential chemotherapeutic target for the treatment of Toxoplasma gondii infections Toxoplasma gondii

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapor-diffusion method, structure of a binary complex of adenosine kinase and the nonhydrolysable ATP analog AMP-PCP is determined to 1.1 A resolution Toxoplasma gondii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + adenosine Toxoplasma gondii the obligate intracellular parasite Toxoplasma gondii is incapable of synthesizing purine nucleotides de novo and relies completely on purines salvaged from the host cells. Adenosine is the preferred precursor and is phosphorylated by adenosine kinase (AK), the most active enzyme in adenosine metabolism in Toxoplasma gondii ?
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Organism

Organism UniProt Comment Textmining
Toxoplasma gondii Q9TVW2
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + adenosine the obligate intracellular parasite Toxoplasma gondii is incapable of synthesizing purine nucleotides de novo and relies completely on purines salvaged from the host cells. Adenosine is the preferred precursor and is phosphorylated by adenosine kinase (AK), the most active enzyme in adenosine metabolism in Toxoplasma gondii Toxoplasma gondii ?
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