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Literature summary for 2.7.1.20 extracted from

  • Maj, M.; Singh, B.; Gupta, R.S.
    The influence of inorganic phosphate on the activity of adenosine kinase (2000), Biochim. Biophys. Acta, 1476, 33-42.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phosphate the degree of dependence varies among enzyme source and pH. At pH 6.2, complete dependence Cricetulus griseus
phosphate the degree of dependence varies among enzyme source and pH. At pH 6.2, complete dependence Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
adenosine
-
Bos taurus
adenosine
-
Cricetulus griseus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.7 6.4 adenosine affinity increases asymptotically upon the addition of increasing phosphate from 1 to 50 mM Cricetulus griseus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
beef
-
Cricetulus griseus
-
chinese hamster
-
Cricetulus griseus
-
CHO cells
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO cell
-
Cricetulus griseus
-
liver beef Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + adenosine
-
Cricetulus griseus ADP + AMP
-
?
ATP + adenosine
-
Bos taurus ADP + AMP
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
higher affinity for adenosine and lower sensitivity to substrate inhibition in the presence of phosphate Cricetulus griseus
7.4
-
higher affinity for adenosine and lower sensitivity to substrate inhibition in the presence of phosphate Bos taurus