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Literature summary for 2.7.1.20 extracted from

  • Fassett, J.; Xu, X.; Kwak, D.; Zhu, G.; Fassett, E.K.; Zhang, P.; Wang, H.; Mayer, B.; Bache, R.J.; Chen, Y.
    Adenosine kinase attenuates cardiomyocyte microtubule stabilization and protects against pressure overload-induced hypertrophy and LV dysfunction (2019), J. Mol. Cell. Cardiol., 130, 49-58 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.20

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule
-
 Mus musculus 5874
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + adenosine Mus musculus the major route of myocardial adenosine metabolism. Receptor-independent role of adenosine for adenosine kinase-mediated adenosine metabolism in cardiomyocyte microtubule dynamics and protection against maladaptive hypertrophy ADP + AMP
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P55264
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiac muscle fiber
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + adenosine
-
 Mus musculus ADP + AMP
-
 ?
ATP + adenosine the major route of myocardial adenosine metabolism. Receptor-independent role of adenosine for adenosine kinase-mediated adenosine metabolism in cardiomyocyte microtubule dynamics and protection against maladaptive hypertrophy Mus musculus ADP + AMP
-
 ?

Synonyms

Synonyms Comment Organism
ADK
-
 Mus musculus

General Information

General Information Comment Organism
malfunction disruption of adenosine kinase causes spontaneous cardiac hypertrophy Mus musculus
metabolism the enzyme is involved in myocardial adenosine metabolism. Cardiomyocyte adenosine kinase expression attenuates pressure overload induced hypertrophy. Aadenosine kinase regulates cardiac mTORC1 and p44/42 ERK MAP kinase signaling. Adenosine metabolism by adenosine kinase diminishes detyrosinated microtubules Mus musculus